Progestin is an effective endocrine treatment for patients with atypical hyperplasia or with endometrial carcinoma that is estrogen receptor (ER) positive and progesterone receptor (PR) positive. However, long-term progestin treatment may lead to resistance. We have studied the progestin resistance phenotype that frequently develops in endometrial...
Although glycogen synthase kinase-3 (GSK-3) might act as a tumor suppressor since its inhibition is expected to mimic the activation of Wnt-signaling pathway, GSK-3beta may contribute to NF-kappaB activation in cancer cells leading to increased cancer cell proliferation and survival. Here we report that GSK-3beta activity was involved in the prolif...
School of Humanities The School of Humanities, composed of three Departments and two Centers, offers two undergraduate programs, three master degree programs, one professional master degree program, and two Ph. D programs in four academic categoriess covering Chinese Language and Literature, History, Philosophy, and Art. The School has 1551 students and 141 full-time faculty members, among which 28 are professors, 3 are Zhiyuan chair professors, 1 is Jingyu Chair professor, and 6 are distinguished professors, 1 is elected in Shanghai Thousand Talents Program, 2 are involved in the New Century Excellent Talent Support Project of the MOE, China and 24 teachers hold overseas doctoral degrees. The School offers 40% of the core courses for liberal education in the whole university and undertaks a total number of 74 projects at the ministrial and provincial level or above, among which 41 are programs supported by the national social science foundation of China.
Objective: To detect mRNA levels and expression of CD44, CD54, CD29 and E-cadherin (E-cad) and to discuss their relationship with formation and drug resistance of ovarian cancer SKOV3ip1 multicellular aggregates. Methods: Liquid overlay system was employed to obtain multicellular aggregates. mRNA levels and expression of CD44, CD54, CD29 and E-cad...
... Mediator complex subunit 19 (MED19) is a member of the mediator that has a key role in the activation and repression of signal transduction or the regulation of transcription in carcinomas ( Casamassimi and Napoli, 2007;Sun et al, 2011). Accumulating evidence has shown that MED19 has important roles in cancer cell proliferation and tumorigenesis, and suppression of MED19 expression induces inhibition of cell proliferation and tumorigenesis in several different tumour types including lung cancer, pancreatic cancer, ovarian cancer and breast cancer ( Liu et al, 2012;Wei et al, 2015). Then we speculated that miR-214 played tumorigenic role by its target MED19 in CRC. ...
KoGuan Law School Legal education at Shanghai Jiao Tong University can be traced back to special and political classes during the period of Nanyang College in September 1901. However, it was interrupted during the education reform in 1950s until the Law School was re-established on June 8 2002. The law School received the new title “KoGuan School of Law” in 2008 in memorial of the generous donation of Professor Leo KoGuan. KoGuan School of Law has a strong, well-structured and international team of faculty, including 65 full-time faculty members. A variety of research centers within the law school has produced high quality scholarship covering a wide range of fields and disciplines, from constitutional law to law and society, from maritime law to competition law, etc. KoGuan School of Law has explored its own style of educating a new generation of law students and future jurists, and established its own reputation in both academic and practical circles. For the time being, it offers a full-scale legal education system including LLB, LLM, JM, and PhD programs.
In 1896, the Nanyang Public School (南洋公學) was founded in Shanghai by the imperial edict of the Guangxu Emperor, under the Business and Telegraphs Office of the Qing imperial government. Four schools were established: a normal school, a school of foreign studies, a middle school, and a high school. Sheng Xuanhuai, the mandarin who proposed the idea to the Guangxu Emperor, became the first president and is, along with missionary educator John Calvin Ferguson, regarded as the founder of the university.
Persistent unopposed estrogen stimulation is a central oncogenic mechanism driving the formation of type I endometrial cancer (EC). Recent epidemiologic and clinical studies of EC have also revealed a role for insulin resistance, clinically manifested by chronic inflammation. However, the role of inflammation in estrogen-driven EC is not well chara...
Chemoresistance is the major obstacle to cure endometrial cancer, whereas metformin has demonstrated sensitization to chemotherapy in endometrial cancer. A novel finding states that isocitrate dehydrogenase 1 (IDH1) involves in cancer chemoresistance. Recent studies have revealed that epigenetic modifications facilitate chemoresistance. However, wh...

To investigate the inhibitory effect of the mammalian target of rapamycin (mTOR) inhibitor, sirolimus on expression of hypoxia-inducible factor (HIF)1alpha protein and growth of ovarian carcinoma in an athymic mouse xenogeneic transplant model of ovarian cancer. Four groups of female nude mice were inoculated subcutaneously with SKOV3 cells. After...
FKBP14 belongs to the family of FK506-binding proteins (FKBPs). Altered expression of FKBPs has been reported in several malignancies. This study aimed to reveal the expression profile of FKBP14 in ovarian cancer and evaluate whether FKBP14 is a molecular target for cancer therapy. We found that the FKBP14 mRNA level was significantly higher in ova...
... Temserolimus was FDA approved for the treatment of advanced renal cell carcinoma in 2007 and is currently being evaluated in several clinical trials for its use in the treatment of gynecologic malignancies, including ovarian carcinoma.[28] Cell culture studies [10,293031 and mouse models323334353637 also suggested that PI3K pathway inhibitors are efficient in suppressing ovarian cancer cell growth. We analyzed the effect of the PI3K, AKT and mTORC1 inhibitors LY294002, SH-6 and rapamycin, respectively, on ovarian cancer cell growth using established cell lines and fresh human tumor tissue. ...

The Ministry of Commerce assumed administration of the college in 1904, and in 1905 changed the college's name to Imperial Polytechnic College of the Commerce Ministry. In 1906, the college was placed under the Ministry of Posts and Telegraphs, and its name was changed to Shanghai Industrial College of the Ministry of Posts and Telegraphs. When the Republic of China was founded, the college was placed under the Ministry of Communications and its name was once again changed, this time to Government Institute of Technology of the Communications Ministry.

RAB25 belongs to the Rab family of small GTPases and is implicated in the development of various types of human cancer. To evaluate the role of RAB25 in ovarian cancer, RAB25 was knocked down by siRNA in HEY and ES‑2 human ovarian cancer cells. Autophagy, cell growth and cell apoptosis were evaluated. The results showed that knockdown of RAB25 incr...
To explore possibility of vasculogenic mimicry induced by hypoxia and the inhibitive effect by sirolimus in epithelial ovarian carcinoma in vitro. Based on three-dimensional cell culture system developed by Matrigel, ovarian cell lines SKOV3 and ES2 were induced under conditions of hypoxia, hypoxia added with sirolimus and no-hypoxia, respectively....
Our previous studies have showed that Gankyrin expression is correlated with a malignant phenotype in endometrial carcinoma. Here, we investigated the possible role of Gankyrin in cervical disease. The increasing protein level of Gankyrin was observed in high-grade cervical intraepithelial neoplasia and carcinoma compared with benign cervical tissu...
Background: The aim of present study was to investigate the role of the prognostic nutritional index (PNI) used as a prognostic marker for predicting response and survival outcomes in patients with epithelial ovarian cancer (EOC) who are receiving platinum-based chemotherapy. Patients and methods: Patients with a new diagnosis of EOC receiving p...

School of Mechanical Engineering The history of the School of Mechanical Engineering (ME) , Shanghai Jiao Tong University (SJTU) dates back to 1913. The School has the vision of a world-class engineering school committed to high-level education and cutting edge research. It aims to offer the best learning experience to its students, the most rewarding working environment for its faculty and staff as well as the most effective service to industry and society. Among the 334 faculty members, 124 are professors, 152 are associate professors and 58 are assistant professors, and more than 5000 students are learning here. As one of the top Schools of Mechanical Engineering in China, it strives to increase its international competitiveness and global presence through quality teaching, advanced research and close collaboration with leading universities in the world. The alumni from the School, as scientists, engineers, educators, statesmen and entrepreneurs, always make outstanding contributions to the innovation of science and technology, and the development of the society.
A few highly aggressive and malignant tumor cells could acquire identities by turning on genes expressed by endothelial cells and recruit blood vessels to sustain tumor growth. Hypoxia was reported recently to play an essential role in these events. These 'plastic' tumor-cell phenotypes and the exact mechanism driving transendothelial differentiati...
To identify an effective auxiliary therapy for epithelial ovarian cancer. Progesterone acetate given at 250 mg intramuscularly twice a week for 1 month followed by increased administration to 500 mg intramuscularly every two weeks for 3 years was used in combination with platinum based chemotherapy to treat patients with epithelial ovarian cancer a...

In the year 404, Huiyuan wrote a treatise On Why Monks Do Not Bow Down Before Kings (沙門不敬王者論).[4] This book symbolized his efforts to assert the political independence of Buddhist clergy from the courts of monarchic rulers. At the same time, it was a religious and political text that aimed to convince monarchs and Confucian-minded ministers of state that followers of Buddhism were ultimately not subversive. He argued that Buddhists could make good subjects in a kingdom due to their beliefs in retribution of karma and the desire to be reborn in paradise. Despite the Buddhists' reputation of leaving their family behind for a monastic life, Huiyuan stated "those who rejoice in the Way of the Buddha invariably first serve their parents and obey their lords."[1]
Most buildings on campus were influenced by American architecture, while the main gate, which was built in 1935, is of traditional Chinese style reflecting the University's earlier status as the "Imperial Polytechnic College". The approaches to the main gate were via a series of marble bridges, similar to, although smaller than, those built in front of Tiananmen. However, recent road expansions have demolished the river as well as most of bridges. A copy of this famous gate scene have been built on the east of Minhang campus.
Metformin plays an important role in the inhibition of cancer cell growth and prolongs remission durations. It reverses progestin-resistance in endometrial cancer cells by downregulating glyoxalase I (GloI) expression. This study aimed to investigate the effect of metformin on endometrial cancer cell chemotherapeutic sensitivity and explore the und...
On February 13, 2004, Yuntai Mountain as the fifth in the world, the third in the country China, was named the world's first World Geopark by UNESCO and caused attention at home and abroad. Meanwhile, Yuntaishan is also a national scenic spot, National Civilized Scenic Area, the first national AAAAA-level scenic spot, national natural heritage, national forest parks, national macaque nature reserve. Yuntain Mountain also has Asia's highest head drop waterfall.
Jiaozuo (Chinese: 焦作; pinyin: Jiāozuò [tɕjáu.tswô]; postal: Tsiaotso) is a prefecture-level city in northern Henan province, China. Sitting on the northern bank of the Yellow River, it borders the provincial capital of Zhengzhou to the south, Xinxiang to the east, Jiyuan to the west, Luoyang to the southwest, and the province of Shanxi to the north.Jiaozuo is one of the core cities of the Central Plains urban agglomeration and a regional central city in the Jin-Yu border area.link
Because the activation of telomerase is a relatively early event in the progression of cervical carcinogenesis, the expression of the human telomerase RNA gene, TERC, has the potential to serve as a biomarker for both the diagnosis and prognosis of cervical neoplasias. In total, 83 research centers participated in the study, and 7786 patients were...
Aberrant nuclear factor-erythroid 2 (NRF2) expression correlates with tumor development. We investigated NRF2 expression in ovarian epithelial carcinoma (OEC), aiming to identify associations with clinicopathological factors, hormones and induced reactive oxygen species (ROS). Immunohistochemical staining for NRF2 expression was performed on 10 ben...
The pathogenesis of preeclampsia is unclear but is thought to be related to shallow trophoblast invasion. An invasive phenotype is acquired by trophoblasts through the process of epithelial-mesenchymal transition (EMT). We proposed that EMT in trophoblasts is deregulated in preeclampsia. The homeobox gene DLX4 plays an important role in epithelial-...
When the Japanese surrendered in 1945, neither the Communist Party of China (CPC) nor the Kuomintang KMT trusted each other or were actively cooperating. After American-sponsored attempts to negotiate a coalition government failed in 1946, the Chinese Civil War resumed. The CPC defeated the Nationalists in 1949, forcing Chiang's government to retreat to Taiwan. During the evacuation, a part of faculty and alumni was taken to Taiwan by Chiang Kai-shek, founding National Chiao Tung University in Taiwan in 1958.

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) can induce apoptosis in various cancer cell lines with little toxicity toward normal cells. It offers a promising therapeutic method against ovarian cancer. Endothelial progenitor cells (EPCs) could home to tumor lesion, and take part in angiogenesis. This study was to observe antitumo...


School of Foreign Languages Founded in 1979, SFL today boasts a contingent of high-caliber faculty known for their innovative teaching and award-winning research. Its 80 plus professors and associate professors work in English, Japanese, German, French, Translation Departments and College English Divisions. The dedicated and talented faculty are actively engaged in a wide array of research fields including theoretical and applied linguistics, English literature, translation studies, to name but a few. Their works appear in distinguished international journals as well as in books published by leading academic presses. SLF seeks to achieve the highest standards of teaching and learning in both sciences and humanities with an emphasis on critical and creative thinking, to serve the needs of the society by enhancing its intellectual life and contributing to the development of the nation. Apart from offering degree programs (BA, MA, PhD) in languages and translation, SFL is also responsible for designing and delivering a broad and diverse range of language-related courses to undergraduate and postgraduate students across the University. Following SJTU’s time-honored tradition of intellectual excellence and critical enquiry, SFL is committed to providing a learning experience of the highest quality for its students who are taught and guided by inspiring academics, making its graduates highly sought after by employers in various sectors.
School of Media and Design Established in 2002, School of Media and Design (SMD) at Shanghai Jiao Tong University aims at educating a new generation of communication graduates who are not only equipped with critical thinking but also with creative capability. The School consists of four departments: Journalism & Communication, Film & Television, Design, and Cultural Industry & Management. To date, SMD has more than 90 faculty members. About 25% of them earned their doctoral degrees in the U.S., U.K., and other western countries. SMD also hosts more than 700 undergraduates, 300 master students, and 100 doctoral students. There are currently 324 international students in the school. Among them 104 are master or doctoral students who come from 55 countries including the U.S., U.K., France, Australia, Russia, South Korea, Pakistan etc. Many of them graduated from world prestigious universities like Princeton University, University of Chicago, University of South California and University of California-Los Angeles.
Ovarian clear cell adenocarcinoma (OCCA) is an aggressive ovarian malignancy with a poor prognosis. The role of estrogen receptor β (ERβ) in the development of OCCA remains to be clarified. To investigate the action of ERβ in the proliferation and invasion of OCCA cells, the ES-2 cell line was stably transfected with full-length human ERβ cDNA, and...
Recent studies have suggested that follicle-stimulating hormone (FSH) plays an important role in ovarian epithelial carcinogenesis. We demonstrated that FSH stimulates the proliferation and invasion of ovarian cancer cells, inhibits apoptosis, and facilitates neovascularisation. Our previous work has shown that transient receptor potential channel...
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