Progesterone plays an important role in the regulation of normal endometrium function by binding to progesterone receptor (PR). In endometrial cancer, however, PR is always down-regulated. Previous reports showed that methylation in the promoter region of the PR gene may be responsible for PRB isoform repression. However, the CpG islands in the exo...
Follicle-stimulating hormone (FSH) and the FSH receptor contribute to tumor angiogenesis and are acknowledged risk factors for ovarian epithelial cancer (OEC). Accumulating evidence suggests that FSH can induce vascular endothelial growth factor (VEGF) and hypoxia inducible factor 1α (HIF1α) expression. We previously demonstrated that FSH induces r...

Huang Yaoshi is a loner who harbours unorthodox and heretical views on traditional Chinese rites and social norms. He is the master of Peach Blossom Island. Apart from being a formidable martial artist, he is also versed in other fields such as military strategy, music and divination. His eccentric personality causes him to be feared and shunned by others.
... Interestingly, estradiol may play a dual role in modulating NRF2 activity. On the one hand, its metabolites activate NRF2 via the generation of reactive oxygen species (ROS) (independent of the ER) [29]. While recent studies demonstrated that estradiol leads to an activation of NRF2 in a wide range of cell types [30,31], the estradiol effect was only noted on protein and not on mRNA levels, suggesting that the main effect of estradiol is based on NRF2 protein stabilization [32]. ...

Huang Yaoshi is married to Feng Heng and has six apprentices. He has scores of servants on his island, who are deaf and mute. Rumours in the jianghu say that he intentionally disabled them, but in fact, they were already mute and deaf before they became his servants. He recruited them as his servants to relieve them from the social stigma of their impairments so that they can enjoy a better life on his island. However, he does not wish to promote an image of himself as a kind and compassionate person so he spread those negative rumours about himself. Only his family and apprentices know the truth.


Obesity is generally acknowledged as a risk factor for endometrial cancer, as accumulated adipocytes partly contribute to the increased production of estrogen which is involved in dysregulated cell growth and metastasis in early endometrial carcinogenesis. Thus we evaluated in this study expression of the fat mass and obesity-associated (FTO) gene...

School of Pharmacy SJTU School of Pharmacy was founded in 2000, and now it has 85 academic, administrative and technical staff members. The School has 17 research and teaching laboratories covering the complete spectrum of curriculum and disciplines of pharmacy education and research including medicinal chemistry, pharmacology, pharmaceutics, pharmaceutical microbiology & biochemistry, pharmacognosy, and traditional Chinese medicine. SJTU School of Pharmacy is a research-orientated institution. Its graduate student body, enrolled in Ph.D., M.Sc. and M.Eng. programs, is as twice larger as its undergraduate classes. Both of the undergraduate and graduate courses are given by individual research laboratories each consisting of a professor and two to four junior academic staffs. SJTU School of Pharmacy has not only developed scientific programs but also nurtured an educational and research environment that is liberal and innovation-orientated. The school has now become a leading institute and an ideal place for pharmacy education and pharmaceutical research in the nation.
To investigate the inhibitory effects of Snail--a zinc finger transcription factor, anti-sense plasmid on the invasion of ovary carcinoma cell lines in vitro. Four human ovarian carcinoma cell lines ES-2, OVCAR3, HO8910, HO8910PM were analyzed for the expression of Snail and E-cadherin mRNA by RT-PCR. Then anti-Snail plasmid transfection was introd...
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