Ovarian epithelial cancer is the leading cause of death among gynecological malignancies. FSH may increase the risk of ovarian malignancy and play an important role in ovarian carcinogenesis. Our previous studies showed that FSH increases the expression of VEGF through survivin. In this study, the function and mechanism of FSH in ovarian cancer wer...

... The influence of E2 on iron metabolism as depicted in ▶ Fig. 1 has been attributed to its ability to reduce HAMP synthesis and maintain/enhance FPN expression in human breast (MCF-7) and ovarian (SKOV-3) cell lines [29][30][31]. Reduced HAMP synthesis in E2-treated human liver HuH7 and Hep-G2 cells was attributed to the binding of E2-ER to E2 responsive elements (EREs) in the HAMP gene [32,33]. Use of the E2 antagonist ICI 182,780 was shown to inhibit E2-induced downregulation of HAMP gene [33]. ...


Genistein, the most abundant phytoestrogen in soybeans, may bind to estrogen receptors and perform anticancer activities. Choriocarcinoma is a malignant, trophoblastic and aggressive cancer of the placenta. Few studies are currently available concerning the effects of genistein on choriocarcinoma. In the present study, we investigated the effect of...
... Previous studies have discovered high IKCal expressions in endometrial carcinoma, breast cancer, urinary bladder carcinoma, colon cancer, and glioblastoma cells. [4][5][6][7] This study demonstrated the close relationship between the Ca 2+ -activated K + channel and cervical cancer. [8,9] This study utilized the K + -channel blocker clotrimazole (CLT) and small hairpin ribonucleic acid (RNA) to explore the role played by (and the effect of) IKCal in the proliferation of HeLa cells. ...
... These clinical and basic science studies therefore suggest that P4 might be useful as an adjunct treatment for ovarian cancer. In fact one study using a xenograph ovarian tumor model has shown that high doses of P4 enhance the apoptotic action of cisplatin [5], which is consistent with a very limited clinical trial data [6]. Unfortunately other trials in both animal and humans have been relatively unsuccessful (See review by Ho [2]). ...
Henan Polytechnic University (HPU)[1], with a history of nearly 100 years, is the first mining university in Chinese history. Its former is Jiaozuo Coal Mining School which was established by the British Syndicate Co. Ltd., in 1909. It has changed its names several times in the course of development, namely, FuZhong Coal Mining University, Jiaozuo Private Institute of Technology, North-west Institute of Technology, Jiaozuo National Institute of Technology, Jiaozuo Mining Institute and Jiaozuo Institute of Technology. The University resumed its name of Henan Polytechnic University in 2004.
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