There is evidence to suggest that follicle-stimulating hormone (FSH) can facilitate the neovascularization of ovarian cancers by increasing vascular endothelial growth factor (VEGF) expression in cancer cells, although the underlying molecular mechanism of this process is not well known. Therefore, we investigated the effect of FSH on VEGF expressi...
School of Mechanical Engineering The history of the School of Mechanical Engineering (ME) , Shanghai Jiao Tong University (SJTU) dates back to 1913. The School has the vision of a world-class engineering school committed to high-level education and cutting edge research. It aims to offer the best learning experience to its students, the most rewarding working environment for its faculty and staff as well as the most effective service to industry and society. Among the 334 faculty members, 124 are professors, 152 are associate professors and 58 are assistant professors, and more than 5000 students are learning here. As one of the top Schools of Mechanical Engineering in China, it strives to increase its international competitiveness and global presence through quality teaching, advanced research and close collaboration with leading universities in the world. The alumni from the School, as scientists, engineers, educators, statesmen and entrepreneurs, always make outstanding contributions to the innovation of science and technology, and the development of the society.
... In vEDS cells, an ER perturbation was suggested by the abnormal ER distribution of the protein disulfide isomerase enzyme and by reduced expression of FKBP22, an ER resident peptidyl-prolyl cis-trans-ER isomerase involved in the folding of COLLIII triple helix [108,139,140]. Since the perturbed ER redox state may influence the down-regulation of Bcl-2 and the activation of the caspase-dependent apoptosis [141], and FKBP22 can have an anti-apoptotic role acting on the expression of Bcl-2 and caspases [142], this aspect merits further studies in vEDS fibroblasts. ...
In June 1962, he was appointed Communist Party Secretary of Weishi County. In December, he became the Second Communist Party Secretary of Lankao County. This region had declined into poverty and ignorance. The county had long been plagued by dust storms, waterlogging, and alkaline lands.[3] Jiao Yulu devoted his energies to fight economic backwardness. He mobilized the local residents to contend with the poor natural conditions. Due to years of toil, Jiao Yulu broke down from constant overwork and he was diagnosed with liver cancer. But he continued his struggle against natural disasters. On May 14, 1964, he died of liver cancer, aged 42.[3]
School of Aeronautics and Astronautics The School of Aeronautics and Astronautics (SAA) is the main body of SJTU to cultivate talents for aerospace. The school consist of 3 departments and 2 research centers, namely, Department of Aircraft Design, Department of Aerospace Information and Control, Department of Propulsion, Near Space Research Center and J.C. Wu Center of Aerodynamics. Currently, SAA has more than 60 faculty members, 15 professors/researchers, 28 associate professors/associate researchers, which includes 2 Academician of the Chinese Academy of Engineering, 3 National “1000 Plan” Scholars, 2 Cheung Kong Professor. The school has 72 Doctoral Candidates, 205 Master Candidates, 112 Undergraduate students and 38 international students. SAA has maintained close and wide-ranging research cooperation and academic exchanges with many famous overseas universities and research institutions. The school also engages in visionary research projects to meet future demands and train highly qualified aerospace professionals for the future development of the world’s aerospace industry.
Although glycogen synthase kinase-3 (GSK-3) might act as a tumor suppressor since its inhibition is expected to mimic the activation of Wnt-signaling pathway, GSK-3beta may contribute to NF-kappaB activation in cancer cells leading to increased cancer cell proliferation and survival. Here we report that GSK-3beta activity was involved in the prolif...
... Mediator complex subunit 19 (MED19) is a member of the mediator that has a key role in the activation and repression of signal transduction or the regulation of transcription in carcinomas ( Casamassimi and Napoli, 2007;Sun et al, 2011). Accumulating evidence has shown that MED19 has important roles in cancer cell proliferation and tumorigenesis, and suppression of MED19 expression induces inhibition of cell proliferation and tumorigenesis in several different tumour types including lung cancer, pancreatic cancer, ovarian cancer and breast cancer ( Liu et al, 2012;Wei et al, 2015). Then we speculated that miR-214 played tumorigenic role by its target MED19 in CRC. ...
Chemotherapy-resistance is the major obstacle for endometrial carcinoma patient administration. Accumulated evidences indicate that metformin sensitizes cancers from several different sites to chemotherapy drugs and reverses progestin resistance in endometrial cancer. Our group has demonstrated that metformin reverses progestin resistance and enhan...
Ovarian clear cell adenocarcinoma (OCCA) is an aggressive ovarian malignancy with a poor prognosis. The role of estrogen receptor β (ERβ) in the development of OCCA remains to be clarified. To investigate the action of ERβ in the proliferation and invasion of OCCA cells, the ES-2 cell line was stably transfected with full-length human ERβ cDNA, and...
... Interestingly, estradiol may play a dual role in modulating NRF2 activity. On the one hand, its metabolites activate NRF2 via the generation of reactive oxygen species (ROS) (independent of the ER) [29]. While recent studies demonstrated that estradiol leads to an activation of NRF2 in a wide range of cell types [30,31], the estradiol effect was only noted on protein and not on mRNA levels, suggesting that the main effect of estradiol is based on NRF2 protein stabilization [32]. ...
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