School of Biomedical Engineering The School of Biomedical Engineering (BME) aims to satisfy the major needs of global development and meet the demand for interdisciplinary programs between medicine, science, and engineering. Based on the current frontiers of international research, major national needs, interdisciplinary programs, and the existing foundation of SJTU, BME consists the following six disciplines: Biomedical Instrumentation, Neuroscience and Engineering, Medical Imaging & Informatics, Nano-biomaterials, Systems Biology & Medicine, and Biological Sciences & Diseases. BME has been dedicated in cultivating high-level research, development, and management talents that are internationally competitive in the field of biomedical engineering.
... However, no clear morphologic changes were found between control cells and Snail-knockdown cells. 16 Although the Ecadherin expression could not be detected in these cells at protein lever (Fig. 1a), but there is significant upregulation of E-cadherin mRNA after knockdown expression of Snail (Fig. 1b), indicating that Snail is required to suppress the expression of E-cadherin in ovarian cancer. In addition, expression of fibronectin, one of the mesenchymal markers, was greatly downregulated in the stable antisense-Snail-transfected cells when compared with the parental cells (Fig. 1b). ...
Antai College of Economics and Management Antai College of Economics and Management (ACEM), Shanghai Jiao Tong University boasts a rich history and tradition which dates back to the Business School of Nan Yang Public School founded in 1903. ACEM is dedicated to educate economic and management talents with international competencies. It promotes scientific and academic innovation, caters to economic and social development, and supports the growth of business. After over 30 years’ unremitting efforts, ACEM has established itself as a modern business school with a good reputation home and abroad, and the first business school in mainland China to have been triply accredited by AACSB, EQUIS and AMBA, the three largest and most influential business school accreditation associations in the world.
Because the activation of telomerase is a relatively early event in the progression of cervical carcinogenesis, the expression of the human telomerase RNA gene, TERC, has the potential to serve as a biomarker for both the diagnosis and prognosis of cervical neoplasias. In total, 83 research centers participated in the study, and 7786 patients were...
Early detection and monitoring the treatment remain the most important factors in improving long-term survival of ovarian cancer patients. New biomarkers that individually or in combination improve the diagnostic performance of existing tumor markers are critically needed. This study uses proteomic approaches to identify new biomarkers for detectio...
Genistein, the most abundant phytoestrogen in soybeans, may bind to estrogen receptors and perform anticancer activities. Choriocarcinoma is a malignant, trophoblastic and aggressive cancer of the placenta. Few studies are currently available concerning the effects of genistein on choriocarcinoma. In the present study, we investigated the effect of...
Our previous study revealed that estrogen regulates nm23-H1 expression thus promoting cell migration-invasion via activating PIK3/Akt pathway. In this study, we explored the effect of hormone on hypoxia-inducible factor-1 (HIF-1alpha), a key factor in cancer invasion and metastasis, via activation of Akt signaling transduction pathway. We treated t...
In the same year, Feng Heng was pregnant with Huang Rong. When she learnt that the copy she wrote had been stolen, she attempted to write another from memory for her husband. However, the stress was too much for her to bear so she died shortly after giving birth to Huang Rong. Huang Yaoshi was deeply tramautised by the loss of his wife and driven to near-insanity. He vented his anger on his other four apprentices (Qu Lingfeng, Lu Chengfeng, Wu Mianfeng and Feng Mofeng) by crippling them and banishing them from his island.
The university's School of International Education is located here, where a large number of international students take classes throughout the academic year (however, most international students that take degree courses are in Minhang campus). The campus still houses a variety of scientific research institutions, State Key Laboratory of Ocean Engineering for instance, although most moved to the new campus since 1987.

School of Naval Architecture, Ocean and Civil Engineering The School of Naval Architecture, Ocean and Civil Engineering (NAOCE) has a strong tradition of excellence and is comprised of five departments: naval architecture and ocean engineering, engineering mechanics, civil engineering, architecture, and transportation and shipping logistics. It is the home of the State Key Laboratory of Ocean Engineering and the Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration. The naval architecture and ocean engineering program has been ranked No. 1 in 2017 Shanghai Ranking’s Global Ranking of Academic Subjects. The School also features two state key disciplines (Naval Architecture and Ocean Engineering; Mechanics). The School has 224 faculty members, including 78 professors and 90 associate professors. Among them, there are seven academicians of CAS and CAE, eight Thousand Talents Plan experts, six MOE Cheung Kong Scholars, and two NSFC distinguished young researchers.
Huang Yaoshi is a fictional character in the wuxia novel The Legend of the Condor Heroes and its sequel, The Return of the Condor Heroes, by Jin Yong. He is one of the Five Greats of the wulin (martial artists' community) during the Song dynasty, alongside Wang Chongyang, Hong Qigong, Ouyang Feng and Duan Zhixing. He is nicknamed "Eastern Heretic" (東邪) for being an unorthodox radical who behaves as he wishes without showing any regard for formalities or moral ethics.[SheDiao Ch.10] He loathes the dogma of traditional rites in Chinese society and admires only genuine honour and pure love.[SheDiao Ch.10] As such, he is often regarded by his contemporaries as a cultural heretic.[SheDiao Ch.10] His nickname may be translated to "Eastern Evil" because the character Xie (邪) in his nickname also refers to "evil" and "unorthodoxy" in jianghu terminology.
... In order to investigate their capability to acquire a "mesenchymal-like" phenotype, we exposed these cells to both FSH and epidermal growth factor (EGF) that are well known to promote the epithelial-to-mesenchymal transition (EMT) in different cell models [37][38][39][40][41]. Thus, adherent "spindle-like" cells appeared after 48 h of culture and developed a monolayer within about 15 days (Figure 5a). ...
Ovarian cancer causes more deaths than any other type of female reproductive cancer. The development of new therapeutic approaches is required due to the low survival rate using routine methods. The goal of this study was to investigate the effect of the gene silencing of mediator complex subunit 19 (MED19) on cell viability and tumor growth in ova...
Estrogen and progestin are involved in ovarian carcinogenesis. Change in nm23-H1 expression and the PIK3/AKT pathway are involved in carcinogenesis, development, invasion and metastasis of ovarian cancers. Therefore, it is critical to understand the signaling pathways that regulate hormone-induced cell migration and invasion in ovarian cancer. We i...

... However, no clear morphologic changes were found between control cells and Snail-knockdown cells. 16 Although the Ecadherin expression could not be detected in these cells at protein lever (Fig. 1a), but there is significant upregulation of E-cadherin mRNA after knockdown expression of Snail (Fig. 1b), indicating that Snail is required to suppress the expression of E-cadherin in ovarian cancer. In addition, expression of fibronectin, one of the mesenchymal markers, was greatly downregulated in the stable antisense-Snail-transfected cells when compared with the parental cells (Fig. 1b). ...

... [9,25] Overall, the main reasons reported contributing to the psychosocial burden among women (anxious, fearful, self-blame, powerlessness, disbelief, depression, and anger) in this domain were lack of understanding of abnormal Pap smear results and higher perceived risk of developing cervical cancer which also have negative impact on perception of self. [10,11,26] Domain 3: Worry about human papillomavirus infectivity Women of reproductive age were found to have a significantly higher mean score not only in general but also in both individual items of this domain " worry about HPV infectivity " compared to a menopausal group of women. Our results were quite similar to the study conducted in the United States which reported that women with abnormal Pap smear results were distressed due to a sense of shame or guilt when they came to know that these cervical changes are associated with HPV and which is a sexually transmitted infection. ...
A cultural events package for the international student community at JI, including excursions into the environs of Shanghai, martial arts, Chinese cuisine and similar classes as well as cultural and social events is strongly recommended to be taken by all students at JI. The cost for the whole package is 2,500 RMB and must be paid in advance of coming to JI.

Gestational diabetemellitus (GDM) is a condition whereby a mother's glucose tolerance is impaired with onset or first recognition during pregnancy which is not either type 1 or type 2 diabetes mellitus. Oxidative stress plays an essential role in diabetes, however, whether it also includes in GDM has not been fully clarified. Therefore, we investig...


Extensive exposure to estrogen is generally acknowledged as a risk factor for endometrial cancer. Given that the accumulation of adipocytes also contributes to the increased production of estrogen, in the present study, we evaluated the expression of the fat mass and obesity-associated (FTO) gene in endometrial tumor tissues and further explored th...
... Interestingly, estradiol may play a dual role in modulating NRF2 activity. On the one hand, its metabolites activate NRF2 via the generation of reactive oxygen species (ROS) (independent of the ER) [29]. While recent studies demonstrated that estradiol leads to an activation of NRF2 in a wide range of cell types [30,31], the estradiol effect was only noted on protein and not on mRNA levels, suggesting that the main effect of estradiol is based on NRF2 protein stabilization [32]. ... 
×