Because the activation of telomerase is a relatively early event in the progression of cervical carcinogenesis, the expression of the human telomerase RNA gene, TERC, has the potential to serve as a biomarker for both the diagnosis and prognosis of cervical neoplasias. In total, 83 research centers participated in the study, and 7786 patients were...

To investigate the correlation of hypoxia-inducible factor (HIF)-1alpha and vascular endothelial growth factor (VEGF) or micro-vessel density (MVD). The ovarian cancer cell line SKOV3 was transplanted into nude mice to form xenogeneic tumor. Mice were treated with rapamycin 4 mg/kg, sulindac 100 mg/(kg.d) and saline 200 microl respectively. Express...
USC-SJTU Institute of Cultural and Creative Industry USC-SJTU Institute of Cultural and Creative Industry (ICCI) is jointly established by Shanghai Jiao Tong University (SJTU) and University of Southern California (USC). With supports from all aspects of the society, ICCI aims to develop itself into a pilot of international collaboration in the field of cultural and creative industry.When culture leads, creativity triumphs. Located in the economic and financial center of China and taking the revitalization of the country and the nation as its own mission, Shanghai Jiao Tong University has cultivated numerous elites in politics, science, industries and arts, and has made great contributions to the country’s economics, science and technology, arts, and health care since founded in 1896. There are a number of famous alumni such as Li Shutong (a master of culture and arts), Lu Yan (a Chinese Hollywood Actress), Hong Shen (a dramatist), and Zhu Qizhan (a famous painter). This manifests the great contribution SJTU has made to the culture and creative industry. University of Southern California is located in Los Angeles, the cultural capital of the world. It has enjoyed a long-lasting high reputation for cultivating a large number of elites in the cultural and creative industry.
Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) can induce apoptosis in various cancer cell lines with little toxicity toward normal cells. It offers a promising therapeutic method against ovarian cancer. Endothelial progenitor cells (EPCs) could home to tumor lesion, and take part in angiogenesis. This study was to observe antitumo...
Ovarian cancer is one of the most common cancers which cause female mortality. The knowledge of ovarian cancer initiation and progression is critical to develop new therapeutic strategies to treat and prevent it. Recently, SOX3 has been reported to play a pivotal role in tumor progression. However, the clinical significance of SOX3 in human ovarian...

Shanghai Jiao Tong University (SJTU; Chinese: 上海交通大学) is a major research university in Shanghai. Established on April 8, 1896 as Nanyang Public School by an imperial edict issued by the Guangxu Emperor, it has been referred to as "The MIT of the East" since the 1930s.[5][6][7] It is renowned as one of the oldest, most prestigious and selective universities in China. Shanghai Jiao Tong is a C9 League university and a Chinese Ministry of Education Class A Double First Class University.[8]
The purpose of the study was to explore the role and mechanism of ataxia-telangiectasia mutated (ATM) protein in endometrial carcinogenesis. A reverse-phase protein array (RPPA) was used to analyze the expression of ATM signal pathway proteins in Ishikawa and progesterone-insensitive Ishikawa. ATM expression was detected in endometrium specimens by...
To study the expression of intermediate-conductance-Ca(2+)-activated K(+) (IKCa1) channels in endometrial cancer and its role in regulating proliferation of endometrial cancer cells. Western blot and RT-PCR were used to examine the expression of IKCa1 channels in 13 normal endometrial specimens and 25 endometrial cancer specimens; and RNA interfere...
To investigate the effects of sulindac metabolites on proliferation and apoptosis in the human umbilical vein endothelial cell line ECV304 in vitro. The proliferation profile of ECV304 was determined by methyl thiazolyl tetrazolium (MTT) method. Cell cycle distribution, apoptosis and the ultrastructure of ECV304 were detected by flow cytometry (FCM...
To determine the role of oestrogen receptor α (ERα) in the regulation of survivin expression by 17β-estradiol (E(2)) in ovarian cancer cells and to evaluate the mechanism of E(2) action on ovarian cancer cell migration. We performed RT-PCR and Western blot analysis to assess the expression of ERα in the ovarian cancer cell lines NIH:OVCAR-3 and SKO...
Ovarian cancer is the most lethal malignancy of the female reproductive system with an overall mortality rate of greater than 70%. Our group has demonstrated that Follicle stimulating hormone (FSH) stimulates the proliferation and invasion of ovarian cancer cells, inhibits apoptosis, and facilitates neovascularization by increasing expression of va...

... This process takes place at the beginning of vascular development and during post-natal life (11,22). Myeloid cells and EPCs are recruited by pro-angiogenic or pro-inflammatory factors to the tumor vascular bed, where they differentiate into ECs and give place to neovasculature (23)(24)(25). Vasculogenesis has a modest impact on tumor vascularization when the angiogenesis pathway is active, however, it is recognized as an important rescue process when this pathway is blocked (10,26). For instance, when angiogenesis is inhibited after anti-angiogenic treatment or radiotherapy, myeloid cells, and EPCs are recruited by the stroma-derived factor 1 (SDF-1) in response to an increased level of hypoxia-inducible factor 1α (HIF-1α) (10,26). ...


To study the expression of intermediate-conductance-Ca(2+)-activated K(+) (IKCa1) channels in endometrial cancer and its role in regulating proliferation of endometrial cancer cells. Western blot and RT-PCR were used to examine the expression of IKCa1 channels in 13 normal endometrial specimens and 25 endometrial cancer specimens; and RNA interfere...

... Interestingly, estradiol may play a dual role in modulating NRF2 activity. On the one hand, its metabolites activate NRF2 via the generation of reactive oxygen species (ROS) (independent of the ER) [29]. While recent studies demonstrated that estradiol leads to an activation of NRF2 in a wide range of cell types [30,31], the estradiol effect was only noted on protein and not on mRNA levels, suggesting that the main effect of estradiol is based on NRF2 protein stabilization [32]. ...
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