IQGAP1 is a scaffolding protein and overexpressed in many human tumors, including ovarian cancer. However, the contribution of IQGAP1 to invasive properties of ovarian cancer cells remains unknown. Here, we investigated the effect of IQGAP1-specific short hairpin RNA (shRNA) expressing plasmids on metastatic potential of ovarian cancer HO-8910PM ce...


Ovarian epithelial cancer is the leading cause of death among gynecological malignancies. FSH may increase the risk of ovarian malignancy and play an important role in ovarian carcinogenesis. Our previous studies showed that FSH increases the expression of VEGF through survivin. In this study, the function and mechanism of FSH in ovarian cancer wer...
High levels of gonadotropin are a risk factor for ovarian cancer development. Aberrant gonadotropin levels benefit tumor angiogenesis, but the detailed mechanism is not clear. Therefore, the aim of this study was to investigate the molecular mechanism of high levels of luteinizing hormone (LH) on the promotion of tumor angiogenesis and to outline a...
The pathogenesis of preeclampsia is unclear but is thought to be related to shallow trophoblast invasion. An invasive phenotype is acquired by trophoblasts through the process of epithelial-mesenchymal transition (EMT). We proposed that EMT in trophoblasts is deregulated in preeclampsia. The homeobox gene DLX4 plays an important role in epithelial-...
Chemotherapy-resistance is the major obstacle for endometrial carcinoma patient administration. Accumulated evidences indicate that metformin sensitizes cancers from several different sites to chemotherapy drugs and reverses progestin resistance in endometrial cancer. Our group has demonstrated that metformin reverses progestin resistance and enhan...
School of International and Public Affairs School of International and Public Affairs (SIPA), established in 2003 and located I the heart of downtown Shanghai, has developed itself into one of the most influential and international schools in political science and public administration in China. It is ranked as a top ten public policy school in China by the Chinese Ministry of Education. SIPA consists of four departments: Department of Comparative Politics, Department of Public Administration, Department of International Relations and Department of Public Economics & Social Policy. The school offers both academic and professional degrees in political science and public administration, including one doctoral degree program, six master’s degree programs and one MPA program (Master of Public Administration). MPA program at SIPA is one of the first of its kind among Chinese universities and well-known for its mid-career education. Currently, over 1,500 students from across the globe study at SIPA. In addition, the school also trains public officials, including many mayors and local leaders.

To investigate the effects of follicle stimulating hormone (FSH) on the proliferation, apoptosis, migration and invasion of ovarian cancer cells. Ovarian cancer cells of the lines SKOV-3 and ES-2 were cultured, and treated by FSH of the concentrations of 10, 20, 40, 80, and 160 mU/ml for 48 h or 24 h respectively. The cells without FSH treatment we...


School of International and Public Affairs School of International and Public Affairs (SIPA), established in 2003 and located I the heart of downtown Shanghai, has developed itself into one of the most influential and international schools in political science and public administration in China. It is ranked as a top ten public policy school in China by the Chinese Ministry of Education. SIPA consists of four departments: Department of Comparative Politics, Department of Public Administration, Department of International Relations and Department of Public Economics & Social Policy. The school offers both academic and professional degrees in political science and public administration, including one doctoral degree program, six master’s degree programs and one MPA program (Master of Public Administration). MPA program at SIPA is one of the first of its kind among Chinese universities and well-known for its mid-career education. Currently, over 1,500 students from across the globe study at SIPA. In addition, the school also trains public officials, including many mayors and local leaders.
... Interestingly, estradiol may play a dual role in modulating NRF2 activity. On the one hand, its metabolites activate NRF2 via the generation of reactive oxygen species (ROS) (independent of the ER) [29]. While recent studies demonstrated that estradiol leads to an activation of NRF2 in a wide range of cell types [30,31], the estradiol effect was only noted on protein and not on mRNA levels, suggesting that the main effect of estradiol is based on NRF2 protein stabilization [32]. ...
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