Chemoresistance is the major obstacle to cure endometrial cancer, whereas metformin has demonstrated sensitization to chemotherapy in endometrial cancer. A novel finding states that isocitrate dehydrogenase 1 (IDH1) involves in cancer chemoresistance. Recent studies have revealed that epigenetic modifications facilitate chemoresistance. However, wh...

Gankyrin has been implicated in the formation of multiple cancer types, although its roles in estrogen-driven endometrial carcinoma remain unclarified. We evaluated the expression of Gankyrin in endometrial tissues and further explored its roles in estrogen-driven and GPR30-mediated endometrial cancer cell proliferation. Gankyrin was overexpressed...
Objective: To investigate the expression of P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) and the relationship with cell cycle profiles in ovarian cancer SK-OV-3ip1 multicellular aggregates. Methods: Liquid overlay system was employed to obtain multicellular aggregates. Expression of P-gp and MRP was detected with flow cyt...
On 3 September 2008, Atlantic Industries, a wholly owned subsidiary of The Coca-Cola Company, agreed to buy China Huiyuan Juice for HK$17.9 billion at HK$12.20 per share, three times more than its closing price of HK$4.14 on the previous day. Its shares closed at HK$10.94 on that day.[4] The proposed takeover was subject to anti-monopoly review by the Chinese Ministry of Commerce, which was scheduled to finish on 20 March 2009.[5] On 17 March, it was reported that Coca-Cola was considering abandoning the deal, as Chinese authorities insisted on relinquishing the Huiyuan brand name after acquisition.[6] On 18 March, the Ministry of Commerce disallowed the bid, citing market competition concerns.[7][8]
We previously showed that the expressing level of FSH receptor (FSHR) increased from ovarian epithelial inclusions (OEIs) to benign ovarian epithelial tumors (OETs) and to borderline OETs, whereas FSHR levels decreased with an increase in carcinoma grade. The aim of this study was to investigate the role of FSHR in OET development. MCV152 cells wit...
School of Mathematical Sciences The School of Mathematical Sciences (SMS) enjoys a rich history dating back to the establishment of Department of Mathematics in 1928, 32 years after the founding of the university. One evidence of its place in modern mathematics in China is that the first Congress of the Chinese Mathematical Society was held in 1935 at SJTU. In 2014, the Department of Mathematics was selected by the central government as one of the first four Model Schools for Internationalization, which encourages us to be more internationalization in its practices, vision and outlook. With the growth in size, it was reorganized into the School of Mathematical Sciences in December 2015. With more than 100 faculties members, the school now consists of 3 departments (Mathematics, Applied and Computational Mathematics, and Statistics) and 1 center (Research Center for Mathematics Education).

Background: The aim of present study was to investigate the role of the prognostic nutritional index (PNI) used as a prognostic marker for predicting response and survival outcomes in patients with epithelial ovarian cancer (EOC) who are receiving platinum-based chemotherapy. Patients and methods: Patients with a new diagnosis of EOC receiving p...

... Temserolimus was FDA approved for the treatment of advanced renal cell carcinoma in 2007 and is currently being evaluated in several clinical trials for its use in the treatment of gynecologic malignancies, including ovarian carcinoma.[28] Cell culture studies [10,293031 and mouse models323334353637 also suggested that PI3K pathway inhibitors are efficient in suppressing ovarian cancer cell growth. We analyzed the effect of the PI3K, AKT and mTORC1 inhibitors LY294002, SH-6 and rapamycin, respectively, on ovarian cancer cell growth using established cell lines and fresh human tumor tissue. ...
Sun Min, wife of a Chinese businessman, was found guilty of insider trading in Huiyuan shares by the Market Misconduct Tribunal in Hong Kong. The businessman, Mo Feng, and Sun purchased 8.61 million shares in the company between 30 July and 29 August 2008, at between HK$3.78 and 4.66 (US$0.48–$0.60), then resold their shares HK$10.24–$11.12 (US$1.21–$1.43) each on 3–4 Sept. 2008, after Huiyuan's stock price had surged after the proposed takeover was announced. A profit of HK$55.1 million (US$7.09 million) was made from the trade.[9] Sun was convicted of having dealt in 3.13 million Huiyuan shares in August 2008[10] and was fined HK$20 million (US$2.56 million), the largest ever imposed for the crime in the territory.[11]
To investigate the effects of sulindac metabolites on proliferation and apoptosis in the human umbilical vein endothelial cell line ECV304 in vitro. The proliferation profile of ECV304 was determined by methyl thiazolyl tetrazolium (MTT) method. Cell cycle distribution, apoptosis and the ultrastructure of ECV304 were detected by flow cytometry (FCM...
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