RAB25 belongs to the Rab family of small GTPases and is implicated in the development of various types of human cancer. To evaluate the role of RAB25 in ovarian cancer, RAB25 was knocked down by siRNA in HEY and ES‑2 human ovarian cancer cells. Autophagy, cell growth and cell apoptosis were evaluated. The results showed that knockdown of RAB25 incr...
Students from SJTU have won top prizes in various competitions, including ACM International Collegiate Programming Contest, International Mathematical Contest in Modeling and Electronics Design Contests. Famous alumni of SJTU or its predecessors include Jiang Zemin, James S.C. Chao Lu Dingyi, Ding Guangen, Wang Daohan, Qian Xuesen, Wu Wenjun, Zou Taofen, Mao Yisheng, Cai Er, Huang Yanpei, Shao Lizi, Wang An, David K. Cheng, Jimmy H. C. Lin and many more. More than 200 of the academicians of the Chinese Academy of Sciences and Chinese Academy of Engineering are alumni of Jiao Tong University.
Epithelial ovarian cancer (EOC) remains the most lethel gynecological malignancy. In the absence of an effective screening strategy, two thirds of patients are diagnosed in advanced clinical stage. Despite chemotherapy with cisplatin and paclitxel, primary or acquired chemoresistance faciltates survival of cancer cells, resulting in disease recurre...
Recent studies have suggested that follicle-stimulating hormone (FSH) plays an important role in ovarian epithelial carcinogenesis. We demonstrated that FSH stimulates the proliferation and invasion of ovarian cancer cells, inhibits apoptosis, and facilitates neovascularisation. Our previous work has shown that transient receptor potential channel...
Albanian Leke 16American Dollars 53Argentine Pesos 43Australian Dollars 29Australian Pounds 15Austrian Schilling 27Bahraini Dinars 27Barbadian Dollars 18Belgian Francs 96Bosnia and Herzegovina convertible marks 29Brazilian Reais 26British Pounds 85Brunei Dollars 43Bulgarian Leva 45Canadian Dollars 59CFA francs Central Africa 10CFA francs West Africa 10CFP francs French Polynesia 15Chilean Pesos 22Chinese Yuan 49Colombian Pesos 12Croatian Kuna 23Cypriot Pounds 19Czech Koruna 34Danish Kroner 43Deutsche Marks 84Dutch Guilders 45Eastern Caribbean Dollars 34Egyptian Pounds 46Estonian Krooni 17Euros 21Falkland Islands Pounds 18Faroese Kronur 23Finnish Markkaa 25French Francs 92Georgian Lari 19Gibraltar Pounds 28Greek Drachmas 30Guernsey Pounds 22Hong Kong Dollars 117Hungarian Forints 28Icelandic Kronur 25Indian Rupees 33Indonesian Rupiah 27Irish Pounds 35Isle of Man Pounds 15Israeli New Sheqalim 21Italian Lire 37Jamaican Dollars 20Japanese Yen 30Jersey Pounds 29Jordanian Dinars 10Kuwaiti Dinars 37Latvian Lats 15Lithuanian Litu 24Luxembourgish Francs 14Macedonian Denari 19Malaysian Ringgit 52Maldivian Rufiyaa 15Maltese Lira 20Mexican Pesos 32Moldovan Lei 9Moroccan Dirhams 37New Taiwan Dollars 33New Zealand Dollars 41New Zealand Pounds 9Northern Irish Pounds 73Norwegian Kroner 25Omani Rials 14Peruvian Soles 17Philippine Peso 22Polish Zloty 50Portuguese Escudos 29Qatari Riyals 25Romanian Lei 11Romanian Old Lei 6Russian Rubles 38Saudi Riyals 26Scottish Pounds 69Serbian Dinara 26Singapore Dollars 58Slovak Koruna 13Slovenian Tolars 31South African Rands 44South Korean Won 37Spanish Pesetas 63Sri Lankan Rupees 55Swedish Kronor 38Swiss Francs 36Thai Baht 50Tunisian Dinars 5Turkish Lira 18Turkish Old Lira 15UAE Dirhams 25Ukrainian Hryvnia 30UncategorizedVietnamese Dong 26
Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) can induce apoptosis in various cancer cell lines with little toxicity toward normal cells. It offers a promising therapeutic method against ovarian cancer. Endothelial progenitor cells (EPCs) could home to tumor lesion, and take part in angiogenesis. This study was to observe antitumo...
To identify new genetic risk factors for cervical cancer, we conducted a genome-wide association study in the Han Chinese population. The initial discovery set included 1,364 individuals with cervical cancer (cases) and 3,028 female controls, and we selected a 'stringently matched samples' subset (829 cases and 990 controls) from the discovery set...
IQGAP1 is a scaffolding protein and overexpressed in many human tumors, including ovarian cancer. However, the contribution of IQGAP1 to invasive properties of ovarian cancer cells remains unknown. Here, we investigated the effect of IQGAP1-specific short hairpin RNA (shRNA) expressing plasmids on metastatic potential of ovarian cancer HO-8910PM ce...
Persistent unopposed estrogen stimulation is a central oncogenic mechanism driving the formation of type I endometrial cancer (EC). Recent epidemiologic and clinical studies of EC have also revealed a role for insulin resistance, clinically manifested by chronic inflammation. However, the role of inflammation in estrogen-driven EC is not well chara...
Ovarian cancer is the most lethal malignancy of the female reproductive system with an overall mortality rate of greater than 70%. Our group has demonstrated that Follicle stimulating hormone (FSH) stimulates the proliferation and invasion of ovarian cancer cells, inhibits apoptosis, and facilitates neovascularization by increasing expression of va...
Zhou Botong realised that he had been tricked by Huang Yaoshi so he returned to Peach Blossom Island to demand an explanation from Huang. Huang Yaoshi was still embattled by the loss of his wife. Zhou Botong's confrontational attitude merely fuelled the anger and frustration in him. When Huang Yaoshi blamed Zhou Botong for his wife's death, Zhou retorted angrily that he had also suffered in a similar experience with Liu Ying. Huang Yaoshi and Zhou Botong started fighting but neither of them was able to defeat his opponent. Huang Yaoshi imprisoned Zhou Botong on his island by sealing all possible exit routes. Zhou Botong roamed the island and settled in a cave for the next 15 years. During that period of time, Huang Yaoshi and Zhou Botong taunted each other to fight and kept themselves occupied with their conflict. Their feud is resolved when Guo Jing visits the island and meets Zhou Botong.
To compare the therapeutic and toxic profile of topotecan given intraperitoneally with intravenously in human ovarian cancer xenografted into athymic nude mice. Eighty female Balb-c/nu-nu mice were randomized assigned into eight groups (n=10). Xenografts resulted from intramesentery injection of cultured human ovarian cancer cells SKOV3 in athymic...
To explore possibility of vasculogenic mimicry induced by hypoxia and the inhibitive effect by sirolimus in epithelial ovarian carcinoma in vitro. Based on three-dimensional cell culture system developed by Matrigel, ovarian cell lines SKOV3 and ES2 were induced under conditions of hypoxia, hypoxia added with sirolimus and no-hypoxia, respectively....
To determine the role of oestrogen receptor α (ERα) in the regulation of survivin expression by 17β-estradiol (E(2)) in ovarian cancer cells and to evaluate the mechanism of E(2) action on ovarian cancer cell migration. We performed RT-PCR and Western blot analysis to assess the expression of ERα in the ovarian cancer cell lines NIH:OVCAR-3 and SKO...
Persistent unopposed estrogen stimulation is a central oncogenic mechanism driving the formation of type I endometrial cancer (EC). Recent epidemiologic and clinical studies of EC have also revealed a role for insulin resistance, clinically manifested by chronic inflammation. However, the role of inflammation in estrogen-driven EC is not well chara...
AAeronautics and AstronauticsAgriculture and BiologyAntai College of Economic and ManagementBBiomedical EngineeringCChemistry and Chemical EngineeringChina Europe International Business SchoolChina-UK Low Carbon CollegeEElectronic, Information and Electrical EngineeringEnvironmental Sciences and EngineeringFForeign LanguagesHHumanitiesIInternational and Public AffairsKKoGuan Law SchoolLLife Sciences and BiotechnologyMMarxismMaterials Science and EngineeringMathematical SciencesMechanical Engineering Media and DesignMedicineNNaval Architecture, Ocean and Civil EngineeringPPharmacyPhysical EducationPhysics and AstronomySShanghai Advanced Institute of FinanceSJTU-ParisTech Elite Institute of Technology U UM-SJTU Joint Institute USC-SJTU Institute of Cultural and Creative Industry Z Zhiyuan College
Objective: To investigate the expression of P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) and the relationship with cell cycle profiles in ovarian cancer SK-OV-3ip1 multicellular aggregates. Methods: Liquid overlay system was employed to obtain multicellular aggregates. Expression of P-gp and MRP was detected with flow cyt...
... With respect to other cancers, lithium has been found to be lethal to neuroblastoma cells but not to normal nerve cells (11). A similar effect was found in ovarian cancer cells (12), although a subsequent similar study on ovarian cancer cells suggests only a more modest benefit (13). It is not clear from our reading of the two ovarian cancer papers why the results are significantly different from each other. ...
School of Chemistry and Chemical Engineering School of Chemistry and Chemical Engineering (SCCE) has a glorious history dating back to 1928. Inspired by the mottos “Prudence, Pragmaticality, Erudition, Innovation” at SCCE, we have been highly successful in the development of academic disciplines, research, and education excellence. After years of efforts, we have so far more than 160 faculty members, among whom there are four academicians of the Chinese Academy of Science, two chair professors supported by the “Thousand Talents Program”, and 11 experts supported by the “Thousand Young Talents Program”; a large number of scholars are supported by the National Science Fund for Distinguished Young Scholars, the “Cheung Kong Scholars Program”, the “National 973 Project”, the “National Science Fund for Outstanding Scholars”, etc. We provide comprehensive education programs including three undergraduate programs, four postgraduate programs(two master and two Ph.D. programs), visiting student programs and post-doctoral programs. With its energetic faculty and various education programs, SCCE has been considered as one of the long-standing educators in the field of chemistry and chemical engineering in China.
Huang Yaoshi makes several brief appearances in the sequel. He rescues Cheng Ying from Li Mochou and accepts the child as his student. He develops a special bond with Yang Guo as both of them share the same distaste for the societal norms of their time, and he teaches Yang Guo two of his celebrated skills. Huang Yaoshi also participates in the defence of Xiangyang from Mongol invaders. At the end of the novel, he retains his original title as "Eastern Heretic" of the new "Five Greats" on Mount Hua, alongside Zhou Botong, Yang Guo, Guo Jing and Yideng.
Chemoresistance is the major obstacle to cure endometrial cancer, whereas metformin has demonstrated sensitization to chemotherapy in endometrial cancer. A novel finding states that isocitrate dehydrogenase 1 (IDH1) involves in cancer chemoresistance. Recent studies have revealed that epigenetic modifications facilitate chemoresistance. However, wh...
Jiaozuo is noted for its blast furnaces and machine construction industries. The total GDP of the city in 2017 was 234.28 billion yuan, an increase of 7.4% over the previous year. Among them, the added value of the primary industry was 13.733 billion yuan, up 4.6%; the added value of the secondary industry was 13.841 billion yuan, up 6.7%; the added value of the tertiary industry was 81.143 billion yuan, up 9.1%. The per capita GDP reached 65,936 yuan. The three industrial structures changed from 6.4:59.3:34.3 of 2016 to 5.9:59.5:34.6.link
China Europe International Business School China Europe International Business School (CEIBS), a joint-venture for management education, was co-founded by the Chinese government and European Union (EU) in 1994, with Shanghai Jiao Tong University and the EFMD serving as its executive partners. As China's only business school to originate from government-level collaboration, CEIBS is committed to educating responsible leaders versed in "China Depth, Global Breadth" in line with its motto of "Conscientiousness, Innovation and Excellence". Leaders from the Chinese central government and the EU have respectively lauded CEIBS as "a cradle of excellent executives" and "a role model of EU-China cooperation". CEIBS offers MBA, EMBA, Global EMBA, Finance MBA and Executive Education programmes. Renowned for its academic rigour, CEIBS is the first business school on the Chinese mainland to have been accredited by both EQUIS and AACSB and the only business school in Asia to have simultaneously made it to the Financial Times' top 30 list of MBA, EMBA and Executive Education programmes.
Progesterone plays an important role in the regulation of normal endometrium function by binding to progesterone receptor (PR). In endometrial cancer, however, PR is always down-regulated. Previous reports showed that methylation in the promoter region of the PR gene may be responsible for PRB isoform repression. However, the CpG islands in the exo...

USC-SJTU Institute of Cultural and Creative Industry USC-SJTU Institute of Cultural and Creative Industry (ICCI) is jointly established by Shanghai Jiao Tong University (SJTU) and University of Southern California (USC). With supports from all aspects of the society, ICCI aims to develop itself into a pilot of international collaboration in the field of cultural and creative industry.When culture leads, creativity triumphs. Located in the economic and financial center of China and taking the revitalization of the country and the nation as its own mission, Shanghai Jiao Tong University has cultivated numerous elites in politics, science, industries and arts, and has made great contributions to the country’s economics, science and technology, arts, and health care since founded in 1896. There are a number of famous alumni such as Li Shutong (a master of culture and arts), Lu Yan (a Chinese Hollywood Actress), Hong Shen (a dramatist), and Zhu Qizhan (a famous painter). This manifests the great contribution SJTU has made to the culture and creative industry. University of Southern California is located in Los Angeles, the cultural capital of the world. It has enjoyed a long-lasting high reputation for cultivating a large number of elites in the cultural and creative industry.
School of Materials Science and Engineering School of Materials Science and Engineering, Shanghai Jiao Tong University originated from the metal heat treatment major in 1952, and was established by merging Materials Science Department and Materials Engineering Department in 1997. The School has been ranked among ESI world top 1‰ disciplines for consecutive years, the discipline ranked 31st in 2016 QS world ranking and the 2nd among domestic disciplines. There are about 300 faculty and staff members, including 1 academicians of the Chinese Academy of Sciences,4 academicians of the Chinese Academy of Engineering, 4 YangtzeRiver Scholars and 4 winners of the National Fund for Distinguished Young Scholars of China. The School has about 1,500 students, including about 560 undergraduates, 470 master degree candidates, 360 doctoral candidates and 150 engineering masters. The School has formed 13 distinctive teaching and research teams by compacting discipline orientation and integrating academic teams.
Purpose: It has previously been shown that follicle-stimulating hormone (FSH) and its receptor contribute to epithelial ovarian cancer (EOC) development. Epithelial-mesenchymal transition (EMT) is the early event of metastasis in cancer. Therefore, the aim of this study was to investigate the roles of FSH and the FSH receptor (FSHR) in EMT of EOC....
p53 is the most commonly mutated tumor suppressor gene in human cancers. In addition to the loss of tumor suppression function and exertion of dominant-negative effects over the remaining wild-type protein, several p53 mutants can gain novel oncogenic functions (gain-of-function, GOF) that actively regulate cancer development and progression. In hu...
Ovarian cancer is the leading cause of death among gynecologic cancers and is the fifth leading cause of all cancer-related deaths among women. The development of novel molecular targets is therefore important to many patients. Recently, the SRY-related transcription factor SOX2 has been widely reported to be involved in multiple pathophysiological...
To study the expression of glucose transporter-1 (GLUT1) and its correlation with basic fibroblast growth factor (bFGF) and proliferating cell nuclear antigen (PCNA) in epithelial ovarian neoplasm. Streptavidin-peroxidase complex technique was used to examine the expression of GLUT1, bFGF and PCNA protein in six cases of normal ovarian tissue, 20 c...
... Mediator complex subunit 19 (MED19) is a member of the mediator that has a key role in the activation and repression of signal transduction or the regulation of transcription in carcinomas ( Casamassimi and Napoli, 2007;Sun et al, 2011). Accumulating evidence has shown that MED19 has important roles in cancer cell proliferation and tumorigenesis, and suppression of MED19 expression induces inhibition of cell proliferation and tumorigenesis in several different tumour types including lung cancer, pancreatic cancer, ovarian cancer and breast cancer ( Liu et al, 2012;Wei et al, 2015). Then we speculated that miR-214 played tumorigenic role by its target MED19 in CRC. ...
FKBP14 belongs to the family of FK506-binding proteins (FKBPs). Altered expression of FKBPs has been reported in several malignancies. This study aimed to reveal the expression profile of FKBP14 in ovarian cancer and evaluate whether FKBP14 is a molecular target for cancer therapy. We found that the FKBP14 mRNA level was significantly higher in ova...
... Temserolimus was FDA approved for the treatment of advanced renal cell carcinoma in 2007 and is currently being evaluated in several clinical trials for its use in the treatment of gynecologic malignancies, including ovarian carcinoma.[28] Cell culture studies [10,293031 and mouse models323334353637 also suggested that PI3K pathway inhibitors are efficient in suppressing ovarian cancer cell growth. We analyzed the effect of the PI3K, AKT and mTORC1 inhibitors LY294002, SH-6 and rapamycin, respectively, on ovarian cancer cell growth using established cell lines and fresh human tumor tissue. ...
School of Biomedical Engineering The School of Biomedical Engineering (BME) aims to satisfy the major needs of global development and meet the demand for interdisciplinary programs between medicine, science, and engineering. Based on the current frontiers of international research, major national needs, interdisciplinary programs, and the existing foundation of SJTU, BME consists the following six disciplines: Biomedical Instrumentation, Neuroscience and Engineering, Medical Imaging & Informatics, Nano-biomaterials, Systems Biology & Medicine, and Biological Sciences & Diseases. BME has been dedicated in cultivating high-level research, development, and management talents that are internationally competitive in the field of biomedical engineering.
To investigate the effects of sulindac metabolites on proliferation and apoptosis in the human umbilical vein endothelial cell line ECV304 in vitro. The proliferation profile of ECV304 was determined by methyl thiazolyl tetrazolium (MTT) method. Cell cycle distribution, apoptosis and the ultrastructure of ECV304 were detected by flow cytometry (FCM...
Department of Physical Education Established in 1986, the Physical Education Department of Shanghai Jiao Tong University is directly affiliated to the university. After more than 30 years of development, it has one first-level discipline authorized to offer master degree. There are 82 faculty members including 5 professors, 2 chair professors and 1 academic leader. It has been continuously awarded the "Presedent Cup" for seven times in national university games. The Department focuses on talent cultivation since the very beginning. By adhering to the "four combinations", the department will take teaching as the core, mass sport as the foundation, competition as the highlight and scientific research as the driving force. It will work actively to build the first-level platform with the characteristics of SJTU to cultivate talents by physical education.
Snail, a key inducer of epithelial-mesenchymal transition (EMT), plays an important role in cancer metastasis. To better understand the role of Snail in the metastasis of ovarian carcinoma, expression of Snail was knocked down by antisense-Snail in the highly metastatic ovarian cancer cell line HO8910PM. Gene array analysis revealed that blocking S...

Although glycogen synthase kinase-3 (GSK-3) might act as a tumor suppressor since its inhibition is expected to mimic the activation of Wnt-signaling pathway, GSK-3beta may contribute to NF-kappaB activation in cancer cells leading to increased cancer cell proliferation and survival. Here we report that GSK-3beta activity was involved in the prolif...

The pathogenesis of preeclampsia is unclear but is thought to be related to shallow trophoblast invasion. An invasive phenotype is acquired by trophoblasts through the process of epithelial-mesenchymal transition (EMT). We proposed that EMT in trophoblasts is deregulated in preeclampsia. The homeobox gene DLX4 plays an important role in epithelial-...
School of Materials Science and Engineering School of Materials Science and Engineering, Shanghai Jiao Tong University originated from the metal heat treatment major in 1952, and was established by merging Materials Science Department and Materials Engineering Department in 1997. The School has been ranked among ESI world top 1‰ disciplines for consecutive years, the discipline ranked 31st in 2016 QS world ranking and the 2nd among domestic disciplines. There are about 300 faculty and staff members, including 1 academicians of the Chinese Academy of Sciences,4 academicians of the Chinese Academy of Engineering, 4 YangtzeRiver Scholars and 4 winners of the National Fund for Distinguished Young Scholars of China. The School has about 1,500 students, including about 560 undergraduates, 470 master degree candidates, 360 doctoral candidates and 150 engineering masters. The School has formed 13 distinctive teaching and research teams by compacting discipline orientation and integrating academic teams.
Huang Yaoshi makes several brief appearances in the sequel. He rescues Cheng Ying from Li Mochou and accepts the child as his student. He develops a special bond with Yang Guo as both of them share the same distaste for the societal norms of their time, and he teaches Yang Guo two of his celebrated skills. Huang Yaoshi also participates in the defence of Xiangyang from Mongol invaders. At the end of the novel, he retains his original title as "Eastern Heretic" of the new "Five Greats" on Mount Hua, alongside Zhou Botong, Yang Guo, Guo Jing and Yideng.
Because the activation of telomerase is a relatively early event in the progression of cervical carcinogenesis, the expression of the human telomerase RNA gene, TERC, has the potential to serve as a biomarker for both the diagnosis and prognosis of cervical neoplasias. In total, 83 research centers participated in the study, and 7786 patients were...
... LiCl treatment can induce apoptosis in cancer cells (Kaufmann, 2011) and reduce the incidence of cancer of non-epithelial origin (Cohen et al., 1998). In addition, it has been shown that LiCl treatment can inhibit cancer cell proliferation through Wnt signaling ( Qi et al., 2006). In the present study, our results showed that LiCl treatment affects the expression of miR-17-92 cluster, which is known as oncomir-1 and plays vital roles in a variety of cellular processes such as cell proliferation and apoptosis. ...
School of Mathematical Sciences The School of Mathematical Sciences (SMS) enjoys a rich history dating back to the establishment of Department of Mathematics in 1928, 32 years after the founding of the university. One evidence of its place in modern mathematics in China is that the first Congress of the Chinese Mathematical Society was held in 1935 at SJTU. In 2014, the Department of Mathematics was selected by the central government as one of the first four Model Schools for Internationalization, which encourages us to be more internationalization in its practices, vision and outlook. With the growth in size, it was reorganized into the School of Mathematical Sciences in December 2015. With more than 100 faculties members, the school now consists of 3 departments (Mathematics, Applied and Computational Mathematics, and Statistics) and 1 center (Research Center for Mathematics Education).

In the year 404, Huiyuan wrote a treatise On Why Monks Do Not Bow Down Before Kings (沙門不敬王者論).[4] This book symbolized his efforts to assert the political independence of Buddhist clergy from the courts of monarchic rulers. At the same time, it was a religious and political text that aimed to convince monarchs and Confucian-minded ministers of state that followers of Buddhism were ultimately not subversive. He argued that Buddhists could make good subjects in a kingdom due to their beliefs in retribution of karma and the desire to be reborn in paradise. Despite the Buddhists' reputation of leaving their family behind for a monastic life, Huiyuan stated "those who rejoice in the Way of the Buddha invariably first serve their parents and obey their lords."[1]
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