IQGAP1 is a scaffolding protein and overexpressed in many human tumors, including ovarian cancer. However, the contribution of IQGAP1 to invasive properties of ovarian cancer cells remains unknown. Here, we investigated the effect of IQGAP1-specific short hairpin RNA (shRNA) expressing plasmids on metastatic potential of ovarian cancer HO-8910PM ce...
... Temserolimus was FDA approved for the treatment of advanced renal cell carcinoma in 2007 and is currently being evaluated in several clinical trials for its use in the treatment of gynecologic malignancies, including ovarian carcinoma.[28] Cell culture studies [10,293031 and mouse models323334353637 also suggested that PI3K pathway inhibitors are efficient in suppressing ovarian cancer cell growth. We analyzed the effect of the PI3K, AKT and mTORC1 inhibitors LY294002, SH-6 and rapamycin, respectively, on ovarian cancer cell growth using established cell lines and fresh human tumor tissue. ...
... This process takes place at the beginning of vascular development and during post-natal life (11,22). Myeloid cells and EPCs are recruited by pro-angiogenic or pro-inflammatory factors to the tumor vascular bed, where they differentiate into ECs and give place to neovasculature (23)(24)(25). Vasculogenesis has a modest impact on tumor vascularization when the angiogenesis pathway is active, however, it is recognized as an important rescue process when this pathway is blocked (10,26). For instance, when angiogenesis is inhibited after anti-angiogenic treatment or radiotherapy, myeloid cells, and EPCs are recruited by the stroma-derived factor 1 (SDF-1) in response to an increased level of hypoxia-inducible factor 1α (HIF-1α) (10,26). ...
In 1945, after the defeat of the Japanese in the Second World War, he returned his hometown and joined a militia. He once took part in the battle of liberating Boshan District. Jiao Yulu joined the Communist Party of China in January 1946, and he soon was transferred to Bohai, Shandong and appointed a group leader of the Land Reform movement. By late Chinese Civil War, he worked in Weishi County, Henan province until 1951. In June 1953, he was transferred to Luoyang Mine Machine Manufacturing Plant and worked there until 1962. 

Huang Yaoshi makes several brief appearances in the sequel. He rescues Cheng Ying from Li Mochou and accepts the child as his student. He develops a special bond with Yang Guo as both of them share the same distaste for the societal norms of their time, and he teaches Yang Guo two of his celebrated skills. Huang Yaoshi also participates in the defence of Xiangyang from Mongol invaders. At the end of the novel, he retains his original title as "Eastern Heretic" of the new "Five Greats" on Mount Hua, alongside Zhou Botong, Yang Guo, Guo Jing and Yideng.
Purpose: It has previously been shown that follicle-stimulating hormone (FSH) and its receptor contribute to epithelial ovarian cancer (EOC) development. Epithelial-mesenchymal transition (EMT) is the early event of metastasis in cancer. Therefore, the aim of this study was to investigate the roles of FSH and the FSH receptor (FSHR) in EMT of EOC....
Huiyuan began studying the Zhuangzi and Laozi at a young age, as well as the teachings of Confucius. However, at the age of 21 he was converted in Hebei Province by the Buddhist Dao An, who was a Chinese disciple of a Kuchan missionary. Hearing the sermons of Dao An convinced Huiyuan to "leave the family" and embark on a life of Buddhist teachings.[1] Later, he became a patriarch of Donglin Temple (East Forest Temple) at Mount Lushan. His teachings were various, including the vinaya (戒律), meditation (禪法), abhidharma and Prajna or wisdom. Although Huiyuan did not take the initiative in establishing the relations with the secular world, he had contacts with court and gentry families. Huiyuan was on two occasions invited by the dictator Huan Xuan to take part in the discussions about the status of the clergy and Huiyuan defended the independence of the clergy. Members of the cultured classes came to live on Mount Lu as Huiyuan's lay disciples to take part in the religious life. Besides his teaching and interaction with lay followers of the Buddhist faith, he also upheld a learned correspondence with the monk Kumarajiva.[2]
Recent studies have suggested that follicle-stimulating hormone (FSH) plays an important role in ovarian epithelial carcinogenesis. We demonstrated that FSH stimulates the proliferation and invasion of ovarian cancer cells, inhibits apoptosis, and facilitates neovascularisation. Our previous work has shown that transient receptor potential channel...
Our previous study revealed that estrogen regulates nm23-H1 expression thus promoting cell migration-invasion via activating PIK3/Akt pathway. In this study, we explored the effect of hormone on hypoxia-inducible factor-1 (HIF-1alpha), a key factor in cancer invasion and metastasis, via activation of Akt signaling transduction pathway. We treated t...
The Ministry of Commerce assumed administration of the college in 1904, and in 1905 changed the college's name to Imperial Polytechnic College of the Commerce Ministry. In 1906, the college was placed under the Ministry of Posts and Telegraphs, and its name was changed to Shanghai Industrial College of the Ministry of Posts and Telegraphs. When the Republic of China was founded, the college was placed under the Ministry of Communications and its name was once again changed, this time to Government Institute of Technology of the Communications Ministry.
... Furthermore, a report indicated that some kind of cervical cancer, such as minimal deviation adenocarcinoma, was not associated with high-risk HPV [25]. Qisang et al. [26] reported a significant positive correlation between positive hTERC gain and HR-HPV infection, histopathologic lesions (all P<0.01) in patients with cervical disease. Our study demonstrates that there are 23% HPV-infected positive cases in NNL, and 78.95% in CA group. ...
Objective: To investigate the expression of P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) and the relationship with cell cycle profiles in ovarian cancer SK-OV-3ip1 multicellular aggregates. Methods: Liquid overlay system was employed to obtain multicellular aggregates. Expression of P-gp and MRP was detected with flow cyt...

Background: The aim of present study was to investigate the role of the prognostic nutritional index (PNI) used as a prognostic marker for predicting response and survival outcomes in patients with epithelial ovarian cancer (EOC) who are receiving platinum-based chemotherapy. Patients and methods: Patients with a new diagnosis of EOC receiving p...
To elucidate the mechanisms of nuclear estrogen receptor (ER)-mediated and G protein-coupled receptor 30 (GPR30)-mediated signaling in the regulation of proliferation in ER-positive and ER-negative endometrial cancer cells, two human endometrial carcinoma cell lines, Ishikawa (ER-positive) and KLE (ER-negative), were used. PCR and Western blot anal...

Our previous study showed that Octamer-binding transcription factor 4 (OCT4) expression was upregulated and significantly associated with histological grade through the analysis of OCT4 expression in 159 ovarian cancer tissue samples, and OCT4 mediated follicle-stimulating hormone (FSH)-induced anti-apoptosis in epithelial ovarian cancer. Neverthel...

To investigate the effects of sulindac metabolites on the proliferation and apoptosis of human umbilical vein endothelial cell line ECV304 in vitro. The proliferation of ECV304 was determined by methyl thiazolyl tetrazolium (MTT) method. The cell cycle, apoptosis and the ultrastructure of ECV304 were detected by flow cytometry (FCM) and electron mi...
Huang Yaoshi is very protective of his daughter and loves her with his life as she reminds him of his deceased wife. He imparts all his skills to her since she was a child and hoped to groom her to become his heir. When his daughter reaches adolescence, he decides to find a suitable husband for her. Ouyang Feng visits Peach Blossom Island with his nephew, Ouyang Ke, to propose a marriage between Ouyang Ke and Huang Rong. Huang Yaoshi favours Ouyang Ke and wants him to be his son-in-law. At the same time, Guo Jing also visits the island with his master, Hong Qigong. Hong Qigong nominates his apprentice to be Huang Yaoshi's son-in-law. Huang Yaoshi had met Guo Jing earlier at Guiyun Manor and wants to kill Guo to avenge Chen Xuanfeng.
Since 2003, Shanghai Jiao Tong University has produced the Academic Ranking of World Universities[24] which analyzes the top universities in the world on quality of faculty (40%), research output (40%), quality of education (10%) and performance vs. size (10%).[25] Its ranking is exclusively of research universities, mainly in the empirical sciences.
The Minhang campus is located in the Minhang District on the outskirts of metropolitan Shanghai. This young campus, which was founded in 1987, covers 2,822,903m2 once farmland. Zizhu Science Park, where Intel, ST Microelectronics, Microsoft, Sandisk and other high-tech companies placed their research and development centers, to the south of this campus.
Objective To study the expression of intermediate? conductance? Ca2+-activatedK+ (KCa3.1) channelsin Endometrial cancer tissues and their role in regulating cell cycle of endometrial cancer cells.Methods Real?time PCR and Western blotting analysis were used to examine the expression of KCa3.1 channels in 25 normal endometrial specimens,26 atypical...
Our previous study revealed that estrogen regulates nm23-H1 expression thus promoting cell migration-invasion via activating PIK3/Akt pathway. In this study, we explored the effect of hormone on hypoxia-inducible factor-1 (HIF-1alpha), a key factor in cancer invasion and metastasis, via activation of Akt signaling transduction pathway. We treated t...
Its population was 3,700,000 at the 2016 census whom 1,301,732 live in the built-up area made of 4 urban districts (Jiefang, Shanyang, Zhongzhan and Macun) and Bo'ai County being urbanized. Jiaozuo enjoys a humid subtropical climate with continental climate influences. Winters are cool and relatively dry while summers are hot and often rainy. Average temperature ranges from 0.3 °C in January to 27.5 °C in July. Extremes exist from -22.4 °C to 43.6 °C. Precipitation averages 659 mm.

To assess the estrogen and progestin's effect on protein expression of metastasis repression gene nm23-H1 via regulation of phosphorylation signaling in epithelial ovarian cancer cell line ES-2. Ovarian clear cell adenocarcinom cell line ES-2 was treated by different doses of 17beta-estradiol (estrogen), medroxyprogestogen (progestin) and dimethyl...
The pathogenesis of preeclampsia is unclear but is thought to be related to shallow trophoblast invasion. An invasive phenotype is acquired by trophoblasts through the process of epithelial-mesenchymal transition (EMT). We proposed that EMT in trophoblasts is deregulated in preeclampsia. The homeobox gene DLX4 plays an important role in epithelial-...
Human embryonic stem (hES) cells are able to give rise to a variety of cell lineages under specific culture condition. An effective strategy for stable genetic modification in hES cells may provide a powerful tool for study of human embryogenesis and cell-based therapies. However, gene silences are documented in hES cells. In current study, we inve...
Most buildings on campus were influenced by American architecture, while the main gate, which was built in 1935, is of traditional Chinese style reflecting the University's earlier status as the "Imperial Polytechnic College". The approaches to the main gate were via a series of marble bridges, similar to, although smaller than, those built in front of Tiananmen. However, recent road expansions have demolished the river as well as most of bridges. A copy of this famous gate scene have been built on the east of Minhang campus.
... [9,25] Overall, the main reasons reported contributing to the psychosocial burden among women (anxious, fearful, self-blame, powerlessness, disbelief, depression, and anger) in this domain were lack of understanding of abnormal Pap smear results and higher perceived risk of developing cervical cancer which also have negative impact on perception of self. [10,11,26] Domain 3: Worry about human papillomavirus infectivity Women of reproductive age were found to have a significantly higher mean score not only in general but also in both individual items of this domain " worry about HPV infectivity " compared to a menopausal group of women. Our results were quite similar to the study conducted in the United States which reported that women with abnormal Pap smear results were distressed due to a sense of shame or guilt when they came to know that these cervical changes are associated with HPV and which is a sexually transmitted infection. ...
Most buildings on campus were influenced by American architecture, while the main gate, which was built in 1935, is of traditional Chinese style reflecting the University's earlier status as the "Imperial Polytechnic College". The approaches to the main gate were via a series of marble bridges, similar to, although smaller than, those built in front of Tiananmen. However, recent road expansions have demolished the river as well as most of bridges. A copy of this famous gate scene have been built on the east of Minhang campus.

Recent studies have suggested that follicle-stimulating hormone (FSH) plays an important role in ovarian epithelial carcinogenesis. We demonstrated that FSH stimulates the proliferation and invasion of ovarian cancer cells, inhibits apoptosis, and facilitates neovascularisation. Our previous work has shown that transient receptor potential channel...

Our previous study revealed that estrogen regulates nm23-H1 expression thus promoting cell migration-invasion via activating PIK3/Akt pathway. In this study, we explored the effect of hormone on hypoxia-inducible factor-1 (HIF-1alpha), a key factor in cancer invasion and metastasis, via activation of Akt signaling transduction pathway. We treated t...


To study the expression of intermediate-conductance-Ca(2+)-activated K(+) (IKCa1) channels in endometrial cancer and its role in regulating proliferation of endometrial cancer cells. Western blot and RT-PCR were used to examine the expression of IKCa1 channels in 13 normal endometrial specimens and 25 endometrial cancer specimens; and RNA interfere...
To elucidate the mechanisms of nuclear estrogen receptor (ER)-mediated and G protein-coupled receptor 30 (GPR30)-mediated signaling in the regulation of proliferation in ER-positive and ER-negative endometrial cancer cells, two human endometrial carcinoma cell lines, Ishikawa (ER-positive) and KLE (ER-negative), were used. PCR and Western blot anal...
Objective: This research was carried out to investigate the effectiveness, rationality, and safety of laparotomy management compared with uterine artery embolization (UAE) combined with methotrexate (MTX) for the treatment of deep implantation cesarean scar pregnancy (CSP II). Materials and methods: Data from 29 patients seen between June 2008 and...
School of Foreign Languages Founded in 1979, SFL today boasts a contingent of high-caliber faculty known for their innovative teaching and award-winning research. Its 80 plus professors and associate professors work in English, Japanese, German, French, Translation Departments and College English Divisions. The dedicated and talented faculty are actively engaged in a wide array of research fields including theoretical and applied linguistics, English literature, translation studies, to name but a few. Their works appear in distinguished international journals as well as in books published by leading academic presses. SLF seeks to achieve the highest standards of teaching and learning in both sciences and humanities with an emphasis on critical and creative thinking, to serve the needs of the society by enhancing its intellectual life and contributing to the development of the nation. Apart from offering degree programs (BA, MA, PhD) in languages and translation, SFL is also responsible for designing and delivering a broad and diverse range of language-related courses to undergraduate and postgraduate students across the University. Following SJTU’s time-honored tradition of intellectual excellence and critical enquiry, SFL is committed to providing a learning experience of the highest quality for its students who are taught and guided by inspiring academics, making its graduates highly sought after by employers in various sectors.
Shortly after his marriage to Feng Heng, Huang Yaoshi met Wang Chongyang's junior, Zhou Botong. He learnt from Zhou Botong that Wang Chongyang had died and that Zhou had inherited the Nine Yin Manual. He wanted the book for himself so he tricked Zhou Botong into allowing his wife to read it. Zhou Botong agreed and let her read the second volume of the manual. Feng Heng had eidetic memory so she memorised the book easily. She lied to Zhou Botong that the manual was fake and that it was actually a copy of a book of childish rites she had memorised by heart. She recited the first few verses of the manual verbatim to Zhou Botong, who mistakenly believed her and destroyed the book in anger. After Zhou Botong left, Feng Heng wrote a copy of the manual from memory for her husband.
Ovarian cancer is one of the most common cancers which cause female mortality. The knowledge of ovarian cancer initiation and progression is critical to develop new therapeutic strategies to treat and prevent it. Recently, SOX3 has been reported to play a pivotal role in tumor progression. However, the clinical significance of SOX3 in human ovarian...
Although glycogen synthase kinase-3 (GSK-3) might act as a tumor suppressor since its inhibition is expected to mimic the activation of Wnt-signaling pathway, GSK-3beta may contribute to NF-kappaB activation in cancer cells leading to increased cancer cell proliferation and survival. Here we report that GSK-3beta activity was involved in the prolif...
Ovarian carcinoma is leading cause of death in gynecologic malignancies. The survival rate cannot be improved after routine surgery, chemotherapy, and radiotherapy. Therefore biotherapy becomes the fourth treatment pattern for ovarian carcinoma. Adequate experimental models for the development of biologic therapeutic strategies are needed. Our purp...
To determine the role of oestrogen receptor α (ERα) in the regulation of survivin expression by 17β-estradiol (E(2)) in ovarian cancer cells and to evaluate the mechanism of E(2) action on ovarian cancer cell migration. We performed RT-PCR and Western blot analysis to assess the expression of ERα in the ovarian cancer cell lines NIH:OVCAR-3 and SKO...
The Ministry of Commerce assumed administration of the college in 1904, and in 1905 changed the college's name to Imperial Polytechnic College of the Commerce Ministry. In 1906, the college was placed under the Ministry of Posts and Telegraphs, and its name was changed to Shanghai Industrial College of the Ministry of Posts and Telegraphs. When the Republic of China was founded, the college was placed under the Ministry of Communications and its name was once again changed, this time to Government Institute of Technology of the Communications Ministry.
FKBP14 belongs to the family of FK506-binding proteins (FKBPs). Altered expression of FKBPs has been reported in several malignancies. This study aimed to reveal the expression profile of FKBP14 in ovarian cancer and evaluate whether FKBP14 is a molecular target for cancer therapy. We found that the FKBP14 mRNA level was significantly higher in ova...
Antai College of Economics and Management Antai College of Economics and Management (ACEM), Shanghai Jiao Tong University boasts a rich history and tradition which dates back to the Business School of Nan Yang Public School founded in 1903. ACEM is dedicated to educate economic and management talents with international competencies. It promotes scientific and academic innovation, caters to economic and social development, and supports the growth of business. After over 30 years’ unremitting efforts, ACEM has established itself as a modern business school with a good reputation home and abroad, and the first business school in mainland China to have been triply accredited by AACSB, EQUIS and AMBA, the three largest and most influential business school accreditation associations in the world.

School of Medicine SJTUSM was formally approved under the“211 Project” as a state key university for full development in November, 1997. In July, 2005, Shanghai Jiao Tong University and Shanghai Second Medical University merged to form the new Shanghai Jiao Tong University, jointly supported by Shanghai Municipal Government and the Ministry of Education. In November, 2010, SJTUSM became one of the first ten universities jointly supported by the Ministry of Health and the Ministry of Education. The rich historic background of over one hundred years and heroic journey of more than 50 years have eventually brought about a research-oriented medical school with all-round development in medical education, clinical services, and scientific research, as well as other social services, a medical school with outstanding features and distinct advantages, a strong faculty, and remarkable academic achievements. In the new round of evaluating disciplines in degree and graduate programs organized by the Ministry of Education in 2009, clinical medicine of SJTUSM ranked first nationally, and the comprehensive strength of various disciplines belonged to the first echelon of the nation's medical schools.
To study the expression of VEGF, KDR, MMP-1, and its transcription factor Ets-1 on the interstitial neovasculogenesis in human cervical carcinoma on molecular level, which may provide further theoretic bases on judgement of prognosis and explain interregularity between neovasculagenetic factors. VEGF, KDR, MMP-1, and Ets-1 were detected in 87 cervi...
Huang Yaoshi later regrets bitterly for inflicting such a heavy punishment on his innocent apprentices. He sets off to find his daughter, who has left home after quarrelling with her father. He meets Mei Chaofeng at Guiyun Manor on Lake Tai, where Lu Chengfeng has settled down. He agrees that Mei Chaofeng has been duly punished since she has lost her sense of sight and her husband. He forgives her and asks her to find his other apprentices and bring them back to the manor so he can heal their legs. However, he never saw his other apprentices again: Chen Xuanfeng was killed by Guo Jing; Qu Lingfeng was killed by Shi Yanming; Wu Mianfeng died of illness; Feng Mofeng has become a blacksmith and is killed by Jinlun Guoshi in the sequel. Huang Yaoshi later accepts Lu Chengfeng's son, Lu Guanying, and Qu Lingfeng's daughter, Shagu, as his grand-apprentices.
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