The purpose of the study was to explore the role and mechanism of ataxia-telangiectasia mutated (ATM) protein in endometrial carcinogenesis. A reverse-phase protein array (RPPA) was used to analyze the expression of ATM signal pathway proteins in Ishikawa and progesterone-insensitive Ishikawa. ATM expression was detected in endometrium specimens by...
... The influence of E2 on iron metabolism as depicted in ▶ Fig. 1 has been attributed to its ability to reduce HAMP synthesis and maintain/enhance FPN expression in human breast (MCF-7) and ovarian (SKOV-3) cell lines [29][30][31]. Reduced HAMP synthesis in E2-treated human liver HuH7 and Hep-G2 cells was attributed to the binding of E2-ER to E2 responsive elements (EREs) in the HAMP gene [32,33]. Use of the E2 antagonist ICI 182,780 was shown to inhibit E2-induced downregulation of HAMP gene [33]. ...
A cultural events package for the international student community at JI, including excursions into the environs of Shanghai, martial arts, Chinese cuisine and similar classes as well as cultural and social events is strongly recommended to be taken by all students at JI. The cost for the whole package is 2,500 RMB and must be paid in advance of coming to JI.
Objective To study the expression of intermediate? conductance? Ca2+-activatedK+ (KCa3.1) channelsin Endometrial cancer tissues and their role in regulating cell cycle of endometrial cancer cells.Methods Real?time PCR and Western blotting analysis were used to examine the expression of KCa3.1 channels in 25 normal endometrial specimens,26 atypical...
In the year 404, Huiyuan wrote a treatise On Why Monks Do Not Bow Down Before Kings (沙門不敬王者論).[4] This book symbolized his efforts to assert the political independence of Buddhist clergy from the courts of monarchic rulers. At the same time, it was a religious and political text that aimed to convince monarchs and Confucian-minded ministers of state that followers of Buddhism were ultimately not subversive. He argued that Buddhists could make good subjects in a kingdom due to their beliefs in retribution of karma and the desire to be reborn in paradise. Despite the Buddhists' reputation of leaving their family behind for a monastic life, Huiyuan stated "those who rejoice in the Way of the Buddha invariably first serve their parents and obey their lords."[1]

... [9,25] Overall, the main reasons reported contributing to the psychosocial burden among women (anxious, fearful, self-blame, powerlessness, disbelief, depression, and anger) in this domain were lack of understanding of abnormal Pap smear results and higher perceived risk of developing cervical cancer which also have negative impact on perception of self. [10,11,26] Domain 3: Worry about human papillomavirus infectivity Women of reproductive age were found to have a significantly higher mean score not only in general but also in both individual items of this domain " worry about HPV infectivity " compared to a menopausal group of women. Our results were quite similar to the study conducted in the United States which reported that women with abnormal Pap smear results were distressed due to a sense of shame or guilt when they came to know that these cervical changes are associated with HPV and which is a sexually transmitted infection. ...


... Likewise, our network analyses further support the role of these two GalNAc-Ts in modulating EOC tumorigenesis. Indeed major gene nodes with proven implications in EOC tumorigenesis, including VEGF, PI3K, EZH2, IQGAP1, and HOXD10 [34][35][36][37][38], were downregulated upon GALNT3 ablation. Moreover, multiple gene nodes reported to be involved in EOC progression (such as CUL1 EEF2, PTN, UCHL1, CBX5, USP14, and BMI-1 [39][40][41][42][43][44]) were strongly affected by the GALNT3/T6 double KO. ...


... However, no clear morphologic changes were found between control cells and Snail-knockdown cells. 16 Although the Ecadherin expression could not be detected in these cells at protein lever (Fig. 1a), but there is significant upregulation of E-cadherin mRNA after knockdown expression of Snail (Fig. 1b), indicating that Snail is required to suppress the expression of E-cadherin in ovarian cancer. In addition, expression of fibronectin, one of the mesenchymal markers, was greatly downregulated in the stable antisense-Snail-transfected cells when compared with the parental cells (Fig. 1b). ...
To investigate the inhibitory effects of Snail--a zinc finger transcription factor, anti-sense plasmid on the invasion of ovary carcinoma cell lines in vitro. Four human ovarian carcinoma cell lines ES-2, OVCAR3, HO8910, HO8910PM were analyzed for the expression of Snail and E-cadherin mRNA by RT-PCR. Then anti-Snail plasmid transfection was introd...
China Huiyuan Juice Group Limited (Chinese: 中国汇源果汁集团有限公司; pinyin: Zhōngguó Huìyuán Guǒzhī Jítuán Yǒuxiàn Gōngsī) (SEHK: 1886), established in 1992 and headquartered in Beijing, is the largest privately owned juice producer in China.[1] It is engaged in the manufacture and sales of juice and other beverage products. Its products include fruit juice and vegetable juice, nectars, bottled water, tea, and dairy drinks.[2]

Its population was 3,700,000 at the 2016 census whom 1,301,732 live in the built-up area made of 4 urban districts (Jiefang, Shanyang, Zhongzhan and Macun) and Bo'ai County being urbanized. Jiaozuo enjoys a humid subtropical climate with continental climate influences. Winters are cool and relatively dry while summers are hot and often rainy. Average temperature ranges from 0.3 °C in January to 27.5 °C in July. Extremes exist from -22.4 °C to 43.6 °C. Precipitation averages 659 mm.
China Europe International Business School China Europe International Business School (CEIBS), a joint-venture for management education, was co-founded by the Chinese government and European Union (EU) in 1994, with Shanghai Jiao Tong University and the EFMD serving as its executive partners. As China's only business school to originate from government-level collaboration, CEIBS is committed to educating responsible leaders versed in "China Depth, Global Breadth" in line with its motto of "Conscientiousness, Innovation and Excellence". Leaders from the Chinese central government and the EU have respectively lauded CEIBS as "a cradle of excellent executives" and "a role model of EU-China cooperation". CEIBS offers MBA, EMBA, Global EMBA, Finance MBA and Executive Education programmes. Renowned for its academic rigour, CEIBS is the first business school on the Chinese mainland to have been accredited by both EQUIS and AACSB and the only business school in Asia to have simultaneously made it to the Financial Times' top 30 list of MBA, EMBA and Executive Education programmes.
In the year 404, Huiyuan wrote a treatise On Why Monks Do Not Bow Down Before Kings (沙門不敬王者論).[4] This book symbolized his efforts to assert the political independence of Buddhist clergy from the courts of monarchic rulers. At the same time, it was a religious and political text that aimed to convince monarchs and Confucian-minded ministers of state that followers of Buddhism were ultimately not subversive. He argued that Buddhists could make good subjects in a kingdom due to their beliefs in retribution of karma and the desire to be reborn in paradise. Despite the Buddhists' reputation of leaving their family behind for a monastic life, Huiyuan stated "those who rejoice in the Way of the Buddha invariably first serve their parents and obey their lords."[1]

To investigate the effects of sulindac metabolites on proliferation and apoptosis in the human umbilical vein endothelial cell line ECV304 in vitro. The proliferation profile of ECV304 was determined by methyl thiazolyl tetrazolium (MTT) method. Cell cycle distribution, apoptosis and the ultrastructure of ECV304 were detected by flow cytometry (FCM...
The university's School of International Education is located here, where a large number of international students take classes throughout the academic year (however, most international students that take degree courses are in Minhang campus). The campus still houses a variety of scientific research institutions, State Key Laboratory of Ocean Engineering for instance, although most moved to the new campus since 1987.
Genistein, the most abundant phytoestrogen in soybeans, may bind to estrogen receptors and perform anticancer activities. Choriocarcinoma is a malignant, trophoblastic and aggressive cancer of the placenta. Few studies are currently available concerning the effects of genistein on choriocarcinoma. In the present study, we investigated the effect of...
... Mediator complex subunit 19 (MED19) is a member of the mediator that has a key role in the activation and repression of signal transduction or the regulation of transcription in carcinomas ( Casamassimi and Napoli, 2007;Sun et al, 2011). Accumulating evidence has shown that MED19 has important roles in cancer cell proliferation and tumorigenesis, and suppression of MED19 expression induces inhibition of cell proliferation and tumorigenesis in several different tumour types including lung cancer, pancreatic cancer, ovarian cancer and breast cancer ( Liu et al, 2012;Wei et al, 2015). Then we speculated that miR-214 played tumorigenic role by its target MED19 in CRC. ...
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring au...
Huang Yaoshi makes several brief appearances in the sequel. He rescues Cheng Ying from Li Mochou and accepts the child as his student. He develops a special bond with Yang Guo as both of them share the same distaste for the societal norms of their time, and he teaches Yang Guo two of his celebrated skills. Huang Yaoshi also participates in the defence of Xiangyang from Mongol invaders. At the end of the novel, he retains his original title as "Eastern Heretic" of the new "Five Greats" on Mount Hua, alongside Zhou Botong, Yang Guo, Guo Jing and Yideng.
Our previous study showed that Octamer-binding transcription factor 4 (OCT4) expression was upregulated and significantly associated with histological grade through the analysis of OCT4 expression in 159 ovarian cancer tissue samples, and OCT4 mediated follicle-stimulating hormone (FSH)-induced anti-apoptosis in epithelial ovarian cancer. Neverthel...
To assess the estrogen and progestin's effect on protein expression of metastasis repression gene nm23-H1 via regulation of phosphorylation signaling in epithelial ovarian cancer cell line ES-2. Ovarian clear cell adenocarcinom cell line ES-2 was treated by different doses of 17beta-estradiol (estrogen), medroxyprogestogen (progestin) and dimethyl...
Hello, I'm a student of mandarin Chinese, but only at a beginner level, I have a spoken exam tomorrow and I have written up what I want to say, however I'm not too sure its correct. Note: I haven't used tones on the letters, here's the text. please let me know I will be really grateful! This is what I want it to mean Good morning I am going to speak a little about my life I have 5 family members, mother father brother sister and myself. My mother is a dentist and my father is a business owner they are currently at work. my brother and my sister are both middle school students we live in Woking Surrey but my mother is milanese (italian) my father is (napoli italian) and i also was born in milan. my mom and i go to the solarium once a month. Woking is pretty and very big but has nothing to do at night. However the living habits are very interesting, like the yearly dance off. we go to the cinema, pop concerts and theater. i love going to restourants with my friends. we go to chinese restaurants, italian restaurants and american restaurants I have many hobbies, one of my friends is called prash. we practice kickboxing and kong fu every thursday on monday wednesday thursday and friday i go to uni. I use the train, there is no seats in the mornings but i very much love going to uni. im also a gamer, i own a team with four people. they are called B , Ray, Billy and Yougesh. B is my brother, ray is maltese, billy is english and yougesh is nepalese.We play League of legends, a game very famous in China. thank you for listening. CHINESE::::::: Zaochen hao! Wo yao shuo yi dian guanyu wo de shenghuo Wo jia you wu ge ren , baba mama didi meimei he wo. Wo mama shi yake yisheng he wo baba shi yewu jingli, nimen dou gongzuo xianzai. Wo didi he meimei dou shi zhong xue de xue sheng. Women zhu wojin zai Sali dan wo mama shi yidali Milan ren , baba shi yidali nabulesi ren he ye wo Milan chu sheng . wo he mama qu rengong riguangyu yi ge yue Wo jin shi xiangdang he hen da dan mei you shenme zuo de wangshang raner zher de shenghuo ziguan hen youyisi biru shuo meinian de dou wu. Women qu dianyingyuan, liuxing yinyuehui he juyian. Wo you henduo aihao Wo xihuan qu zai can ting yu wo pengyou. Women qu zhongguo can ting, yidali can ting he meiguo can ting mei yue yici Wo de yi ge pengyou jiao Prash. Women zuo taiquandao he gong fu fang xingqisi. Xingqiyi, xingqisan xingqisi he xingqiwu wo qu daxue wo zui huoche, zhaoshang zhe shi bu zuowei dan wo hen xihuan qu daxue. Wo shi wanjia, wo you yige tuandui you si ge ren. Tamen jiao B, Ray, Billy he Yougesh. B shi wo didi, Ray shi maertaren, billy shi yinguoren he yougesh shi niboren. Women wan yingxiong lianmeng, Zhege youxi hen shou huanying zai zhonguo. Xiexie nin ting THANK YOU to anyone who manages to help <3
Objective: This research was carried out to investigate the effectiveness, rationality, and safety of laparotomy management compared with uterine artery embolization (UAE) combined with methotrexate (MTX) for the treatment of deep implantation cesarean scar pregnancy (CSP II). Materials and methods: Data from 29 patients seen between June 2008 and...
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