To identify new genetic risk factors for cervical cancer, we conducted a genome-wide association study in the Han Chinese population. The initial discovery set included 1,364 individuals with cervical cancer (cases) and 3,028 female controls, and we selected a 'stringently matched samples' subset (829 cases and 990 controls) from the discovery set...
ARHI is a Ras-related imprinted gene that inhibits cancer cell growth and motility. ARHI is downregulated in the majority of breast cancers, and loss of its expression is associated with its progression from ductal carcinoma in situ (DCIS) to invasive disease. In ovarian cancer, re-expression of ARHI induces autophagy and leads to autophagic death...
Huang Yaoshi is a loner who harbours unorthodox and heretical views on traditional Chinese rites and social norms. He is the master of Peach Blossom Island. Apart from being a formidable martial artist, he is also versed in other fields such as military strategy, music and divination. His eccentric personality causes him to be feared and shunned by others.
To observe whether endothelial cell (EC) progenitors (CD(34)(+)-positive mononuclear cells) participated in neovasculogenesis of ovarian epithelial carcinoma through in vitro and in vivo experiments, and to explore the mechanism of tumor neovasculogenesis. CD(34)(+)-positive mononuclear cells were isolated from peripheral blood of ovarian epithelia...
To compare the efficacy of combination regiments of taxol given weekly plus carboplatin and taxol given every three weeks plus carboplatin. To observe the toxicity of the two regiments. To observe the two-year survival rate in the two groups. Total 125 eligible patients in 13 centers of CGOG were entered into the two arms of this randomized clinica...

Although glycogen synthase kinase-3 (GSK-3) might act as a tumor suppressor since its inhibition is expected to mimic the activation of Wnt-signaling pathway, GSK-3beta may contribute to NF-kappaB activation in cancer cells leading to increased cancer cell proliferation and survival. Here we report that GSK-3beta activity was involved in the prolif...

Albanian Leke 16American Dollars 53Argentine Pesos 43Australian Dollars 29Australian Pounds 15Austrian Schilling 27Bahraini Dinars 27Barbadian Dollars 18Belgian Francs 96Bosnia and Herzegovina convertible marks 29Brazilian Reais 26British Pounds 85Brunei Dollars 43Bulgarian Leva 45Canadian Dollars 59CFA francs Central Africa 10CFA francs West Africa 10CFP francs French Polynesia 15Chilean Pesos 22Chinese Yuan 49Colombian Pesos 12Croatian Kuna 23Cypriot Pounds 19Czech Koruna 34Danish Kroner 43Deutsche Marks 84Dutch Guilders 45Eastern Caribbean Dollars 34Egyptian Pounds 46Estonian Krooni 17Euros 21Falkland Islands Pounds 18Faroese Kronur 23Finnish Markkaa 25French Francs 92Georgian Lari 19Gibraltar Pounds 28Greek Drachmas 30Guernsey Pounds 22Hong Kong Dollars 117Hungarian Forints 28Icelandic Kronur 25Indian Rupees 33Indonesian Rupiah 27Irish Pounds 35Isle of Man Pounds 15Israeli New Sheqalim 21Italian Lire 37Jamaican Dollars 20Japanese Yen 30Jersey Pounds 29Jordanian Dinars 10Kuwaiti Dinars 37Latvian Lats 15Lithuanian Litu 24Luxembourgish Francs 14Macedonian Denari 19Malaysian Ringgit 52Maldivian Rufiyaa 15Maltese Lira 20Mexican Pesos 32Moldovan Lei 9Moroccan Dirhams 37New Taiwan Dollars 33New Zealand Dollars 41New Zealand Pounds 9Northern Irish Pounds 73Norwegian Kroner 25Omani Rials 14Peruvian Soles 17Philippine Peso 22Polish Zloty 50Portuguese Escudos 29Qatari Riyals 25Romanian Lei 11Romanian Old Lei 6Russian Rubles 38Saudi Riyals 26Scottish Pounds 69Serbian Dinara 26Singapore Dollars 58Slovak Koruna 13Slovenian Tolars 31South African Rands 44South Korean Won 37Spanish Pesetas 63Sri Lankan Rupees 55Swedish Kronor 38Swiss Francs 36Thai Baht 50Tunisian Dinars 5Turkish Lira 18Turkish Old Lira 15UAE Dirhams 25Ukrainian Hryvnia 30UncategorizedVietnamese Dong 26
p53 is the most commonly mutated tumor suppressor gene in human cancers. In addition to the loss of tumor suppression function and exertion of dominant-negative effects over the remaining wild-type protein, several p53 mutants can gain novel oncogenic functions (gain-of-function, GOF) that actively regulate cancer development and progression. In hu...

Ovarian cancers are heterogeneous and contain stem-like cells that are able to self-renew and are responsible for sustained tumor growth. Metastasis in peritoneal cavity occurs more frequently in ovarian cancer than in other malignancies, but the underlying mechanism remains largely unknown. We have identified that ovarian cancer stem-like cells (C...
Hello, I'm a student of mandarin Chinese, but only at a beginner level, I have a spoken exam tomorrow and I have written up what I want to say, however I'm not too sure its correct. Note: I haven't used tones on the letters, here's the text. please let me know I will be really grateful! This is what I want it to mean Good morning I am going to speak a little about my life I have 5 family members, mother father brother sister and myself. My mother is a dentist and my father is a business owner they are currently at work. my brother and my sister are both middle school students we live in Woking Surrey but my mother is milanese (italian) my father is (napoli italian) and i also was born in milan. my mom and i go to the solarium once a month. Woking is pretty and very big but has nothing to do at night. However the living habits are very interesting, like the yearly dance off. we go to the cinema, pop concerts and theater. i love going to restourants with my friends. we go to chinese restaurants, italian restaurants and american restaurants I have many hobbies, one of my friends is called prash. we practice kickboxing and kong fu every thursday on monday wednesday thursday and friday i go to uni. I use the train, there is no seats in the mornings but i very much love going to uni. im also a gamer, i own a team with four people. they are called B , Ray, Billy and Yougesh. B is my brother, ray is maltese, billy is english and yougesh is nepalese.We play League of legends, a game very famous in China. thank you for listening. CHINESE::::::: Zaochen hao! Wo yao shuo yi dian guanyu wo de shenghuo Wo jia you wu ge ren , baba mama didi meimei he wo. Wo mama shi yake yisheng he wo baba shi yewu jingli, nimen dou gongzuo xianzai. Wo didi he meimei dou shi zhong xue de xue sheng. Women zhu wojin zai Sali dan wo mama shi yidali Milan ren , baba shi yidali nabulesi ren he ye wo Milan chu sheng . wo he mama qu rengong riguangyu yi ge yue Wo jin shi xiangdang he hen da dan mei you shenme zuo de wangshang raner zher de shenghuo ziguan hen youyisi biru shuo meinian de dou wu. Women qu dianyingyuan, liuxing yinyuehui he juyian. Wo you henduo aihao Wo xihuan qu zai can ting yu wo pengyou. Women qu zhongguo can ting, yidali can ting he meiguo can ting mei yue yici Wo de yi ge pengyou jiao Prash. Women zuo taiquandao he gong fu fang xingqisi. Xingqiyi, xingqisan xingqisi he xingqiwu wo qu daxue wo zui huoche, zhaoshang zhe shi bu zuowei dan wo hen xihuan qu daxue. Wo shi wanjia, wo you yige tuandui you si ge ren. Tamen jiao B, Ray, Billy he Yougesh. B shi wo didi, Ray shi maertaren, billy shi yinguoren he yougesh shi niboren. Women wan yingxiong lianmeng, Zhege youxi hen shou huanying zai zhonguo. Xiexie nin ting THANK YOU to anyone who manages to help <3
Huiyuan began studying the Zhuangzi and Laozi at a young age, as well as the teachings of Confucius. However, at the age of 21 he was converted in Hebei Province by the Buddhist Dao An, who was a Chinese disciple of a Kuchan missionary. Hearing the sermons of Dao An convinced Huiyuan to "leave the family" and embark on a life of Buddhist teachings.[1] Later, he became a patriarch of Donglin Temple (East Forest Temple) at Mount Lushan. His teachings were various, including the vinaya (戒律), meditation (禪法), abhidharma and Prajna or wisdom. Although Huiyuan did not take the initiative in establishing the relations with the secular world, he had contacts with court and gentry families. Huiyuan was on two occasions invited by the dictator Huan Xuan to take part in the discussions about the status of the clergy and Huiyuan defended the independence of the clergy. Members of the cultured classes came to live on Mount Lu as Huiyuan's lay disciples to take part in the religious life. Besides his teaching and interaction with lay followers of the Buddhist faith, he also upheld a learned correspondence with the monk Kumarajiva.[2]

To examine the expressions of glyoxalase I (GLO-I) in endometrial cancer tissues and cell lines and to investigate the roles of GLO-I on proliferation and apoptosis in endometrial cancer cells. Immunohistochemistry, western blot and RT-PCR were used to investigate the expressions of GLO-I protein and mRNA in endometrial cancer tissues and Ishikawa...

Chemoresistance is the major obstacle to cure endometrial cancer, whereas metformin has demonstrated sensitization to chemotherapy in endometrial cancer. A novel finding states that isocitrate dehydrogenase 1 (IDH1) involves in cancer chemoresistance. Recent studies have revealed that epigenetic modifications facilitate chemoresistance. However, wh...

... Temserolimus was FDA approved for the treatment of advanced renal cell carcinoma in 2007 and is currently being evaluated in several clinical trials for its use in the treatment of gynecologic malignancies, including ovarian carcinoma.[28] Cell culture studies [10,293031 and mouse models323334353637 also suggested that PI3K pathway inhibitors are efficient in suppressing ovarian cancer cell growth. We analyzed the effect of the PI3K, AKT and mTORC1 inhibitors LY294002, SH-6 and rapamycin, respectively, on ovarian cancer cell growth using established cell lines and fresh human tumor tissue. ...
To investigate the inhibitory effects of Snail--a zinc finger transcription factor, anti-sense plasmid on the invasion of ovary carcinoma cell lines in vitro. Four human ovarian carcinoma cell lines ES-2, OVCAR3, HO8910, HO8910PM were analyzed for the expression of Snail and E-cadherin mRNA by RT-PCR. Then anti-Snail plasmid transfection was introd...

Ovarian epithelial cancer is the leading cause of death among gynecological malignancies. FSH may increase the risk of ovarian malignancy and play an important role in ovarian carcinogenesis. Our previous studies showed that FSH increases the expression of VEGF through survivin. In this study, the function and mechanism of FSH in ovarian cancer wer...
Snail, a key inducer of epithelial-mesenchymal transition (EMT), plays an important role in cancer metastasis. To better understand the role of Snail in the metastasis of ovarian carcinoma, expression of Snail was knocked down by antisense-Snail in the highly metastatic ovarian cancer cell line HO8910PM. Gene array analysis revealed that blocking S...
To study the expression of intermediate-conductance-Ca(2+)-activated K(+) (IKCa1) channels in endometrial cancer and its role in regulating proliferation of endometrial cancer cells. Western blot and RT-PCR were used to examine the expression of IKCa1 channels in 13 normal endometrial specimens and 25 endometrial cancer specimens; and RNA interfere...
Snail, a key inducer of epithelial-mesenchymal transition (EMT), plays an important role in cancer metastasis. To better understand the role of Snail in the metastasis of ovarian carcinoma, expression of Snail was knocked down by antisense-Snail in the highly metastatic ovarian cancer cell line HO8910PM. Gene array analysis revealed that blocking S...
Ovarian cancer is one of the most common cancers which cause female mortality. The knowledge of ovarian cancer initiation and progression is critical to develop new therapeutic strategies to treat and prevent it. Recently, SOX3 has been reported to play a pivotal role in tumor progression. However, the clinical significance of SOX3 in human ovarian...

To identify new genetic risk factors for cervical cancer, we conducted a genome-wide association study in the Han Chinese population. The initial discovery set included 1,364 individuals with cervical cancer (cases) and 3,028 female controls, and we selected a 'stringently matched samples' subset (829 cases and 990 controls) from the discovery set...


Golgi phosphoprotein 3 (GOLPH3), a newly recognized oncogene, is associated with tumor growth, metastasis, and poor prognosis in several types of cancer. However, its biological role and underlying mechanism in epithelial ovarian cancer (EOC) remain poorly understood. Here, we found that GOLPH3 was overexpressed in EOC tissues and cell lines. This...
Endometrial cancer is a common gynecologic malignancy among women. The molecular mechanisms involved in the progression of endometrial cancer are unclear, which has hampered the development of an effective treatment. Survivin, a newly identified member of the inhibitor of apoptosis (IAP) family, regulates 2 critical processes in neoplastic transfor...
... Interestingly, estradiol may play a dual role in modulating NRF2 activity. On the one hand, its metabolites activate NRF2 via the generation of reactive oxygen species (ROS) (independent of the ER) [29]. While recent studies demonstrated that estradiol leads to an activation of NRF2 in a wide range of cell types [30,31], the estradiol effect was only noted on protein and not on mRNA levels, suggesting that the main effect of estradiol is based on NRF2 protein stabilization [32]. ...
KoGuan Law School Legal education at Shanghai Jiao Tong University can be traced back to special and political classes during the period of Nanyang College in September 1901. However, it was interrupted during the education reform in 1950s until the Law School was re-established on June 8 2002. The law School received the new title “KoGuan School of Law” in 2008 in memorial of the generous donation of Professor Leo KoGuan. KoGuan School of Law has a strong, well-structured and international team of faculty, including 65 full-time faculty members. A variety of research centers within the law school has produced high quality scholarship covering a wide range of fields and disciplines, from constitutional law to law and society, from maritime law to competition law, etc. KoGuan School of Law has explored its own style of educating a new generation of law students and future jurists, and established its own reputation in both academic and practical circles. For the time being, it offers a full-scale legal education system including LLB, LLM, JM, and PhD programs.
... This process takes place at the beginning of vascular development and during post-natal life (11,22). Myeloid cells and EPCs are recruited by pro-angiogenic or pro-inflammatory factors to the tumor vascular bed, where they differentiate into ECs and give place to neovasculature (23)(24)(25). Vasculogenesis has a modest impact on tumor vascularization when the angiogenesis pathway is active, however, it is recognized as an important rescue process when this pathway is blocked (10,26). For instance, when angiogenesis is inhibited after anti-angiogenic treatment or radiotherapy, myeloid cells, and EPCs are recruited by the stroma-derived factor 1 (SDF-1) in response to an increased level of hypoxia-inducible factor 1α (HIF-1α) (10,26). ...
Shanghai Advanced Institute of Finance The Shanghai Advanced Institute of Finance (SAIF) was established by the Shanghai Municipal Government at Shanghai Jiao Tong University in April 2009. Its mission is to become a world class institute of research and higher learning with world class faculty. SAIF is committed to developing top talents for the financial world and to generate cutting-edge knowledge in financial theories and applications. As a member of Shanghai's financial community, it strives to contribute to the development of Shanghai as a global financial center.
The construction of the campus never came to an end in the past century. Existing buildings: the Middle College building (built in 1898), the original library (built in 1919), the gymnasium (built in 1925), the administrative building (built in 1933), the Xinjian building (built in 1953), the new Upper College building (built in 1955), the second teaching building (built in 1960), Bao Zhaolong library (built in 1985) and Haoran high-tech building (built in 1996) were constructed one after another.
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