... Temserolimus was FDA approved for the treatment of advanced renal cell carcinoma in 2007 and is currently being evaluated in several clinical trials for its use in the treatment of gynecologic malignancies, including ovarian carcinoma.[28] Cell culture studies [10,293031 and mouse models323334353637 also suggested that PI3K pathway inhibitors are efficient in suppressing ovarian cancer cell growth. We analyzed the effect of the PI3K, AKT and mTORC1 inhibitors LY294002, SH-6 and rapamycin, respectively, on ovarian cancer cell growth using established cell lines and fresh human tumor tissue. ...
Aim: To assess the clinical significance of hTERC amplification for cervical cancer screening detected by fluorescence in situ hybridization (FISH) and compare it with that of current screening methods within the same group. Methods: A total of one hundred and nine women were recruited in this study. All of them had liquid-based thin-prep cytologic...

NANOG is a key transcription factor that is overexpressed and plays an important role in various cancers. Its overexpression is associated with highly tumorigenic, drug-resistant, and poor prognosis. However, the underlying mechanism of action of NANOG in ovarian cancer remains unclear. Epithelial-mesenchymal transition (EMT), which is a critical p...


Objective To study the expression of intermediate? conductance? Ca2+-activatedK+ (KCa3.1) channelsin Endometrial cancer tissues and their role in regulating cell cycle of endometrial cancer cells.Methods Real?time PCR and Western blotting analysis were used to examine the expression of KCa3.1 channels in 25 normal endometrial specimens,26 atypical...
To determine the role of oestrogen receptor α (ERα) in the regulation of survivin expression by 17β-estradiol (E(2)) in ovarian cancer cells and to evaluate the mechanism of E(2) action on ovarian cancer cell migration. We performed RT-PCR and Western blot analysis to assess the expression of ERα in the ovarian cancer cell lines NIH:OVCAR-3 and SKO...
Zhiyuan College The Zhiyuan College, established in January 2010, offers “Zhiyuan Honors Program” to the top 5% SJTU undergraduates. Today, Zhiyuan has seven undergraduate programs: Mathematics, Physics, Life Science, Computer Science, Chemistry, Engineering and Biomedical Science. Aiming at cultivating top-notch talents into international academic masters, Zhiyuan College has recruited a group of eminent scholars from around the world to build first-class faculty team. Each year, Zhiyuan admits 350 students and there are 433 alumni worldwide currently, 90% of whom are pursuing further studies at top domestic and international universities and institutions. In addition to having a strong academic record, students who show a strong interest and the potential to pursue a research career are selected. In 2014, the talent training model of Zhiyuan College won the first-class award of “National Teaching Achievement Award”; and in 2016, “Zhiyuan Model” won “Cultivating Curiosity Award” and “Natural Sciences Award” of “Reimagine Education 2016”, which is jointly hosted by Wharton School of the University of Pennsylvania and QS—international institution for world university rankings on education.
... Interestingly, estradiol may play a dual role in modulating NRF2 activity. On the one hand, its metabolites activate NRF2 via the generation of reactive oxygen species (ROS) (independent of the ER) [29]. While recent studies demonstrated that estradiol leads to an activation of NRF2 in a wide range of cell types [30,31], the estradiol effect was only noted on protein and not on mRNA levels, suggesting that the main effect of estradiol is based on NRF2 protein stabilization [32]. ...
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