... Interestingly, estradiol may play a dual role in modulating NRF2 activity. On the one hand, its metabolites activate NRF2 via the generation of reactive oxygen species (ROS) (independent of the ER) [29]. While recent studies demonstrated that estradiol leads to an activation of NRF2 in a wide range of cell types [30,31], the estradiol effect was only noted on protein and not on mRNA levels, suggesting that the main effect of estradiol is based on NRF2 protein stabilization [32]. ...
School of Foreign Languages Founded in 1979, SFL today boasts a contingent of high-caliber faculty known for their innovative teaching and award-winning research. Its 80 plus professors and associate professors work in English, Japanese, German, French, Translation Departments and College English Divisions. The dedicated and talented faculty are actively engaged in a wide array of research fields including theoretical and applied linguistics, English literature, translation studies, to name but a few. Their works appear in distinguished international journals as well as in books published by leading academic presses. SLF seeks to achieve the highest standards of teaching and learning in both sciences and humanities with an emphasis on critical and creative thinking, to serve the needs of the society by enhancing its intellectual life and contributing to the development of the nation. Apart from offering degree programs (BA, MA, PhD) in languages and translation, SFL is also responsible for designing and delivering a broad and diverse range of language-related courses to undergraduate and postgraduate students across the University. Following SJTU’s time-honored tradition of intellectual excellence and critical enquiry, SFL is committed to providing a learning experience of the highest quality for its students who are taught and guided by inspiring academics, making its graduates highly sought after by employers in various sectors.

Epithelial ovarian cancer (EOC) remains the most lethel gynecological malignancy. In the absence of an effective screening strategy, two thirds of patients are diagnosed in advanced clinical stage. Despite chemotherapy with cisplatin and paclitxel, primary or acquired chemoresistance faciltates survival of cancer cells, resulting in disease recurre...


Objective To study the expression of intermediate? conductance? Ca2+-activatedK+ (KCa3.1) channelsin Endometrial cancer tissues and their role in regulating cell cycle of endometrial cancer cells.Methods Real?time PCR and Western blotting analysis were used to examine the expression of KCa3.1 channels in 25 normal endometrial specimens,26 atypical...
To identify new genetic risk factors for cervical cancer, we conducted a genome-wide association study in the Han Chinese population. The initial discovery set included 1,364 individuals with cervical cancer (cases) and 3,028 female controls, and we selected a 'stringently matched samples' subset (829 cases and 990 controls) from the discovery set...
Hello, I'm a student of mandarin Chinese, but only at a beginner level, I have a spoken exam tomorrow and I have written up what I want to say, however I'm not too sure its correct. Note: I haven't used tones on the letters, here's the text. please let me know I will be really grateful! This is what I want it to mean Good morning I am going to speak a little about my life I have 5 family members, mother father brother sister and myself. My mother is a dentist and my father is a business owner they are currently at work. my brother and my sister are both middle school students we live in Woking Surrey but my mother is milanese (italian) my father is (napoli italian) and i also was born in milan. my mom and i go to the solarium once a month. Woking is pretty and very big but has nothing to do at night. However the living habits are very interesting, like the yearly dance off. we go to the cinema, pop concerts and theater. i love going to restourants with my friends. we go to chinese restaurants, italian restaurants and american restaurants I have many hobbies, one of my friends is called prash. we practice kickboxing and kong fu every thursday on monday wednesday thursday and friday i go to uni. I use the train, there is no seats in the mornings but i very much love going to uni. im also a gamer, i own a team with four people. they are called B , Ray, Billy and Yougesh. B is my brother, ray is maltese, billy is english and yougesh is nepalese.We play League of legends, a game very famous in China. thank you for listening. CHINESE::::::: Zaochen hao! Wo yao shuo yi dian guanyu wo de shenghuo Wo jia you wu ge ren , baba mama didi meimei he wo. Wo mama shi yake yisheng he wo baba shi yewu jingli, nimen dou gongzuo xianzai. Wo didi he meimei dou shi zhong xue de xue sheng. Women zhu wojin zai Sali dan wo mama shi yidali Milan ren , baba shi yidali nabulesi ren he ye wo Milan chu sheng . wo he mama qu rengong riguangyu yi ge yue Wo jin shi xiangdang he hen da dan mei you shenme zuo de wangshang raner zher de shenghuo ziguan hen youyisi biru shuo meinian de dou wu. Women qu dianyingyuan, liuxing yinyuehui he juyian. Wo you henduo aihao Wo xihuan qu zai can ting yu wo pengyou. Women qu zhongguo can ting, yidali can ting he meiguo can ting mei yue yici Wo de yi ge pengyou jiao Prash. Women zuo taiquandao he gong fu fang xingqisi. Xingqiyi, xingqisan xingqisi he xingqiwu wo qu daxue wo zui huoche, zhaoshang zhe shi bu zuowei dan wo hen xihuan qu daxue. Wo shi wanjia, wo you yige tuandui you si ge ren. Tamen jiao B, Ray, Billy he Yougesh. B shi wo didi, Ray shi maertaren, billy shi yinguoren he yougesh shi niboren. Women wan yingxiong lianmeng, Zhege youxi hen shou huanying zai zhonguo. Xiexie nin ting THANK YOU to anyone who manages to help <3
The purpose of the study was to explore the role and mechanism of ataxia-telangiectasia mutated (ATM) protein in endometrial carcinogenesis. A reverse-phase protein array (RPPA) was used to analyze the expression of ATM signal pathway proteins in Ishikawa and progesterone-insensitive Ishikawa. ATM expression was detected in endometrium specimens by...
The aim of present study was to investigate the role of preoperative neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) used as prognostic markers for predicting chemotherapeutic response and survival outcomes in patients with epithelial ovarian cancer (EOC) who are receiving platinum-based chemotherapy. A total of 344 pati...
To identify an effective auxiliary therapy for epithelial ovarian cancer. Progesterone acetate given at 250 mg intramuscularly twice a week for 1 month followed by increased administration to 500 mg intramuscularly every two weeks for 3 years was used in combination with platinum based chemotherapy to treat patients with epithelial ovarian cancer a...
To identify an effective auxiliary therapy for epithelial ovarian cancer. Progesterone acetate given at 250 mg intramuscularly twice a week for 1 month followed by increased administration to 500 mg intramuscularly every two weeks for 3 years was used in combination with platinum based chemotherapy to treat patients with epithelial ovarian cancer a...
Huiyuan (Chinese: 慧遠; Wade–Giles: Hui-yüan; 334–416 AD) was a Chinese Buddhist teacher who founded Donglin Temple on Mount Lushan in Jiangxi province and wrote the text On Why Monks Do Not Bow Down Before Kings in 404 AD. He was born in Shanxi province but after a long life of Buddhist teaching he wound up in Jiangxi province, where he died in 416. Although he was born in the north, he moved south to live within the bounds of the Eastern Jin Dynasty.
To elucidate the mechanisms of nuclear estrogen receptor (ER)-mediated and G protein-coupled receptor 30 (GPR30)-mediated signaling in the regulation of proliferation in ER-positive and ER-negative endometrial cancer cells, two human endometrial carcinoma cell lines, Ishikawa (ER-positive) and KLE (ER-negative), were used. PCR and Western blot anal...

Up to 30% of failure rate in endometrial hyperplasia patients treated by progestin urges more detailed understanding of the mechanisms involved in progestin resistance. Survivin is a key regulator in the antiapoptotic network, and overexpression of survivin has been reported in endometrial hyperplasia and cancer. This study investigated the role of...
Estrogen and progestin are involved in ovarian carcinogenesis. Change in nm23-H1 expression and the PIK3/AKT pathway are involved in carcinogenesis, development, invasion and metastasis of ovarian cancers. Therefore, it is critical to understand the signaling pathways that regulate hormone-induced cell migration and invasion in ovarian cancer. We i...

In the same year, Feng Heng was pregnant with Huang Rong. When she learnt that the copy she wrote had been stolen, she attempted to write another from memory for her husband. However, the stress was too much for her to bear so she died shortly after giving birth to Huang Rong. Huang Yaoshi was deeply tramautised by the loss of his wife and driven to near-insanity. He vented his anger on his other four apprentices (Qu Lingfeng, Lu Chengfeng, Wu Mianfeng and Feng Mofeng) by crippling them and banishing them from his island.
To identify new genetic risk factors for cervical cancer, we conducted a genome-wide association study in the Han Chinese population. The initial discovery set included 1,364 individuals with cervical cancer (cases) and 3,028 female controls, and we selected a 'stringently matched samples' subset (829 cases and 990 controls) from the discovery set...
Previously, we demonstrated that follicle stimulating hormone (FSH) enhanced VEGF expression and facilitated ovarian cancer angiogenesis via the PI3K/AKT signaling pathway. In this study, we further investigated the involvement of microRNA-27a: ZBTB10‑specificity protein pathway in the mechanism of FSH-induced VEGF, Cox2 and survivin expression. Tr...
Progestin is an effective endocrine treatment for patients with atypical hyperplasia or with endometrial carcinoma that is estrogen receptor (ER) positive and progesterone receptor (PR) positive. However, long-term progestin treatment may lead to resistance. We have studied the progestin resistance phenotype that frequently develops in endometrial...
School of Life Sciences and Biotechnology The School of Life Sciences and Biotechnology was jointly founded by Shanghai Jiao Tong University and the Chinese Academy of Sciences (Shanghai branch) in 1997. The 139 faculty members, including 51 full professors and 60 associate professors, are dedicated to cultivating diverse and unique talents in undergraduate students and postgraduate researchers. The School is also home to the State Key Laboratory of Microbial Metabolism and the Key Laboratory for Genetics Development and Neuropsychiatric Disorder. Our faculties, led by two prominent members of the Chinese Academy of Sciences, have earned numerous prestigious awards and international recognitions. By the 2017 ESI-based matrix, we ranked in the top 1% world-wide in Biology and Biochemistry, Molecular Biology and Genetics, Microbiology, and Plant and Animal Science. Hosting two state-level education bases, we administer a six-year combined bachelor-master program and an eight-year bachelor-master-PhD program. 1193 students are currently enrolled, including 303 undergraduates and 890 graduate students.
To compare the therapeutic and toxic profile of topotecan given intraperitoneally with intravenously in human ovarian cancer xenografted into athymic nude mice. Eighty female Balb-c/nu-nu mice were randomized assigned into eight groups (n=10). Xenografts resulted from intramesentery injection of cultured human ovarian cancer cells SKOV3 in athymic...
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