Persistent unopposed estrogen stimulation is a central oncogenic mechanism driving the formation of type I endometrial cancer (EC). Recent epidemiologic and clinical studies of EC have also revealed a role for insulin resistance, clinically manifested by chronic inflammation. However, the role of inflammation in estrogen-driven EC is not well chara...
To investigate the effects of sulindac metabolites on proliferation and apoptosis in the human umbilical vein endothelial cell line ECV304 in vitro. The proliferation profile of ECV304 was determined by methyl thiazolyl tetrazolium (MTT) method. Cell cycle distribution, apoptosis and the ultrastructure of ECV304 were detected by flow cytometry (FCM...
To investigate the effect of glycogen synthase kinase-3beta (GSK-3beta) on the proliferation of human ovarian cancer cells. Two human ovarian cancer cell lines SKOV3 and ES-2 were analysed for the expression of GSK-3beta and phosphorylated GSK-3beta (pGSK-3beta) by Western blot analysis. Cell growth curve analysis done by cell count was used to inv...
Huang Yaoshi later regrets bitterly for inflicting such a heavy punishment on his innocent apprentices. He sets off to find his daughter, who has left home after quarrelling with her father. He meets Mei Chaofeng at Guiyun Manor on Lake Tai, where Lu Chengfeng has settled down. He agrees that Mei Chaofeng has been duly punished since she has lost her sense of sight and her husband. He forgives her and asks her to find his other apprentices and bring them back to the manor so he can heal their legs. However, he never saw his other apprentices again: Chen Xuanfeng was killed by Guo Jing; Qu Lingfeng was killed by Shi Yanming; Wu Mianfeng died of illness; Feng Mofeng has become a blacksmith and is killed by Jinlun Guoshi in the sequel. Huang Yaoshi later accepts Lu Chengfeng's son, Lu Guanying, and Qu Lingfeng's daughter, Shagu, as his grand-apprentices.
Pyruvate kinase (PK) is a key enzyme in the process of glycolysis, catalyzing phosphoenolpyruvate (PEP) into pyruvate. Currently, PK isozyme type M2 (PKM2), one subtype of PK, has been proposed as a new tumor marker with high expression in various tumor tissues. Here we aimed to explore the effects of siRNAPKM2 on ovarian carcinoma (OC) cell lines...

Epithelial ovarian cancer (EOC) remains the most lethel gynecological malignancy. In the absence of an effective screening strategy, two thirds of patients are diagnosed in advanced clinical stage. Despite chemotherapy with cisplatin and paclitxel, primary or acquired chemoresistance faciltates survival of cancer cells, resulting in disease recurre...

IQGAP1 is a scaffolding protein and overexpressed in many human tumors, including ovarian cancer. However, the contribution of IQGAP1 to invasive properties of ovarian cancer cells remains unknown. Here, we investigated the effect of IQGAP1-specific short hairpin RNA (shRNA) expressing plasmids on metastatic potential of ovarian cancer HO-8910PM ce...
Snail, a key inducer of epithelial-mesenchymal transition (EMT), plays an important role in cancer metastasis. To better understand the role of Snail in the metastasis of ovarian carcinoma, expression of Snail was knocked down by antisense-Snail in the highly metastatic ovarian cancer cell line HO8910PM. Gene array analysis revealed that blocking S...
Purpose: It has previously been shown that follicle-stimulating hormone (FSH) and its receptor contribute to epithelial ovarian cancer (EOC) development. Epithelial-mesenchymal transition (EMT) is the early event of metastasis in cancer. Therefore, the aim of this study was to investigate the roles of FSH and the FSH receptor (FSHR) in EMT of EOC....
... Temserolimus was FDA approved for the treatment of advanced renal cell carcinoma in 2007 and is currently being evaluated in several clinical trials for its use in the treatment of gynecologic malignancies, including ovarian carcinoma.[28] Cell culture studies [10,293031 and mouse models323334353637 also suggested that PI3K pathway inhibitors are efficient in suppressing ovarian cancer cell growth. We analyzed the effect of the PI3K, AKT and mTORC1 inhibitors LY294002, SH-6 and rapamycin, respectively, on ovarian cancer cell growth using established cell lines and fresh human tumor tissue. ...
Antai College of Economics and Management Antai College of Economics and Management (ACEM), Shanghai Jiao Tong University boasts a rich history and tradition which dates back to the Business School of Nan Yang Public School founded in 1903. ACEM is dedicated to educate economic and management talents with international competencies. It promotes scientific and academic innovation, caters to economic and social development, and supports the growth of business. After over 30 years’ unremitting efforts, ACEM has established itself as a modern business school with a good reputation home and abroad, and the first business school in mainland China to have been triply accredited by AACSB, EQUIS and AMBA, the three largest and most influential business school accreditation associations in the world.

The purpose of the study was to explore the role and mechanism of ataxia-telangiectasia mutated (ATM) protein in endometrial carcinogenesis. A reverse-phase protein array (RPPA) was used to analyze the expression of ATM signal pathway proteins in Ishikawa and progesterone-insensitive Ishikawa. ATM expression was detected in endometrium specimens by...
... In vEDS cells, an ER perturbation was suggested by the abnormal ER distribution of the protein disulfide isomerase enzyme and by reduced expression of FKBP22, an ER resident peptidyl-prolyl cis-trans-ER isomerase involved in the folding of COLLIII triple helix [108,139,140]. Since the perturbed ER redox state may influence the down-regulation of Bcl-2 and the activation of the caspase-dependent apoptosis [141], and FKBP22 can have an anti-apoptotic role acting on the expression of Bcl-2 and caspases [142], this aspect merits further studies in vEDS fibroblasts. ...
To investigate natural spontaneous menopausal age, menstruation span and their relationship with menarche age and parity in Pudong district of Shanghai. From Jan 2007 to Jul 2008, 15 083 spontaneous menopause women undergoing cervical cancer screening were enrolled in this study. The questionnaire included menarche age, parity, spontaneous menopaus...
School of Humanities The School of Humanities, composed of three Departments and two Centers, offers two undergraduate programs, three master degree programs, one professional master degree program, and two Ph. D programs in four academic categoriess covering Chinese Language and Literature, History, Philosophy, and Art. The School has 1551 students and 141 full-time faculty members, among which 28 are professors, 3 are Zhiyuan chair professors, 1 is Jingyu Chair professor, and 6 are distinguished professors, 1 is elected in Shanghai Thousand Talents Program, 2 are involved in the New Century Excellent Talent Support Project of the MOE, China and 24 teachers hold overseas doctoral degrees. The School offers 40% of the core courses for liberal education in the whole university and undertaks a total number of 74 projects at the ministrial and provincial level or above, among which 41 are programs supported by the national social science foundation of China.

School of Foreign Languages Founded in 1979, SFL today boasts a contingent of high-caliber faculty known for their innovative teaching and award-winning research. Its 80 plus professors and associate professors work in English, Japanese, German, French, Translation Departments and College English Divisions. The dedicated and talented faculty are actively engaged in a wide array of research fields including theoretical and applied linguistics, English literature, translation studies, to name but a few. Their works appear in distinguished international journals as well as in books published by leading academic presses. SLF seeks to achieve the highest standards of teaching and learning in both sciences and humanities with an emphasis on critical and creative thinking, to serve the needs of the society by enhancing its intellectual life and contributing to the development of the nation. Apart from offering degree programs (BA, MA, PhD) in languages and translation, SFL is also responsible for designing and delivering a broad and diverse range of language-related courses to undergraduate and postgraduate students across the University. Following SJTU’s time-honored tradition of intellectual excellence and critical enquiry, SFL is committed to providing a learning experience of the highest quality for its students who are taught and guided by inspiring academics, making its graduates highly sought after by employers in various sectors.


Snail, a key inducer of epithelial-mesenchymal transition (EMT), plays an important role in cancer metastasis. To better understand the role of Snail in the metastasis of ovarian carcinoma, expression of Snail was knocked down by antisense-Snail in the highly metastatic ovarian cancer cell line HO8910PM. Gene array analysis revealed that blocking S...
Ovarian cancer is the most lethal malignancy of the female reproductive system with an overall mortality rate of greater than 70%. Our group has demonstrated that Follicle stimulating hormone (FSH) stimulates the proliferation and invasion of ovarian cancer cells, inhibits apoptosis, and facilitates neovascularization by increasing expression of va...

Our previous study showed that Octamer-binding transcription factor 4 (OCT4) expression was upregulated and significantly associated with histological grade through the analysis of OCT4 expression in 159 ovarian cancer tissue samples, and OCT4 mediated follicle-stimulating hormone (FSH)-induced anti-apoptosis in epithelial ovarian cancer. Neverthel...
To study the expression of VEGF, KDR, MMP-1, and its transcription factor Ets-1 on the interstitial neovasculogenesis in human cervical carcinoma on molecular level, which may provide further theoretic bases on judgement of prognosis and explain interregularity between neovasculagenetic factors. VEGF, KDR, MMP-1, and Ets-1 were detected in 87 cervi...
School of Media and Design Established in 2002, School of Media and Design (SMD) at Shanghai Jiao Tong University aims at educating a new generation of communication graduates who are not only equipped with critical thinking but also with creative capability. The School consists of four departments: Journalism & Communication, Film & Television, Design, and Cultural Industry & Management. To date, SMD has more than 90 faculty members. About 25% of them earned their doctoral degrees in the U.S., U.K., and other western countries. SMD also hosts more than 700 undergraduates, 300 master students, and 100 doctoral students. There are currently 324 international students in the school. Among them 104 are master or doctoral students who come from 55 countries including the U.S., U.K., France, Australia, Russia, South Korea, Pakistan etc. Many of them graduated from world prestigious universities like Princeton University, University of Chicago, University of South California and University of California-Los Angeles.

Recent studies have suggested that follicle-stimulating hormone (FSH) plays an important role in ovarian epithelial carcinogenesis. We demonstrated that FSH stimulates the proliferation and invasion of ovarian cancer cells, inhibits apoptosis, and facilitates neovascularisation. Our previous work has shown that transient receptor potential channel...
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