Ovarian epithelial cancer is the leading cause of death among gynecological malignancies. FSH may increase the risk of ovarian malignancy and play an important role in ovarian carcinogenesis. Our previous studies showed that FSH increases the expression of VEGF through survivin. In this study, the function and mechanism of FSH in ovarian cancer wer...

... These clinical and basic science studies therefore suggest that P4 might be useful as an adjunct treatment for ovarian cancer. In fact one study using a xenograph ovarian tumor model has shown that high doses of P4 enhance the apoptotic action of cisplatin [5], which is consistent with a very limited clinical trial data [6]. Unfortunately other trials in both animal and humans have been relatively unsuccessful (See review by Ho [2]). ...
School of Pharmacy SJTU School of Pharmacy was founded in 2000, and now it has 85 academic, administrative and technical staff members. The School has 17 research and teaching laboratories covering the complete spectrum of curriculum and disciplines of pharmacy education and research including medicinal chemistry, pharmacology, pharmaceutics, pharmaceutical microbiology & biochemistry, pharmacognosy, and traditional Chinese medicine. SJTU School of Pharmacy is a research-orientated institution. Its graduate student body, enrolled in Ph.D., M.Sc. and M.Eng. programs, is as twice larger as its undergraduate classes. Both of the undergraduate and graduate courses are given by individual research laboratories each consisting of a professor and two to four junior academic staffs. SJTU School of Pharmacy has not only developed scientific programs but also nurtured an educational and research environment that is liberal and innovation-orientated. The school has now become a leading institute and an ideal place for pharmacy education and pharmaceutical research in the nation.
Our previous studies have showed that Gankyrin expression is correlated with a malignant phenotype in endometrial carcinoma. Here, we investigated the possible role of Gankyrin in cervical disease. The increasing protein level of Gankyrin was observed in high-grade cervical intraepithelial neoplasia and carcinoma compared with benign cervical tissu...
Huang Yaoshi is a loner who harbours unorthodox and heretical views on traditional Chinese rites and social norms. He is the master of Peach Blossom Island. Apart from being a formidable martial artist, he is also versed in other fields such as military strategy, music and divination. His eccentric personality causes him to be feared and shunned by others.
The Joint Institute has tuition-waived student exchange agreements with a several leading universities as well as various programs with the university of Michigan. If your university is a member of the Global E³ Network or you believe that your institution has an exchange agreement with Shanghai Jiao Tong University (SJTU), please contact your international programs office for information on how to apply.
... Likewise, our network analyses further support the role of these two GalNAc-Ts in modulating EOC tumorigenesis. Indeed major gene nodes with proven implications in EOC tumorigenesis, including VEGF, PI3K, EZH2, IQGAP1, and HOXD10 [34][35][36][37][38], were downregulated upon GALNT3 ablation. Moreover, multiple gene nodes reported to be involved in EOC progression (such as CUL1 EEF2, PTN, UCHL1, CBX5, USP14, and BMI-1 [39][40][41][42][43][44]) were strongly affected by the GALNT3/T6 double KO. ...
On 3 September 2008, Atlantic Industries, a wholly owned subsidiary of The Coca-Cola Company, agreed to buy China Huiyuan Juice for HK$17.9 billion at HK$12.20 per share, three times more than its closing price of HK$4.14 on the previous day. Its shares closed at HK$10.94 on that day.[4] The proposed takeover was subject to anti-monopoly review by the Chinese Ministry of Commerce, which was scheduled to finish on 20 March 2009.[5] On 17 March, it was reported that Coca-Cola was considering abandoning the deal, as Chinese authorities insisted on relinquishing the Huiyuan brand name after acquisition.[6] On 18 March, the Ministry of Commerce disallowed the bid, citing market competition concerns.[7][8]
Objective: The transcription factor Snail, which is implicated in the triggering of epithelial-mesenchymal transitions (EMT), plays an important role in adhesion, invasion and metastasis of tumor cells. In the present study, we assessed 17beta-Estradiol (E2)'s effect on Snail, E-cadherin and MMP-2 expression of epithelial ovarian cancer cell line...
To observe whether endothelial cell (EC) progenitors (CD(34)(+)-positive mononuclear cells) participated in neovasculogenesis of ovarian epithelial carcinoma through in vitro and in vivo experiments, and to explore the mechanism of tumor neovasculogenesis. CD(34)(+)-positive mononuclear cells were isolated from peripheral blood of ovarian epithelia...
Progestin is an effective endocrine treatment for patients with atypical hyperplasia or with endometrial carcinoma that is estrogen receptor (ER) positive and progesterone receptor (PR) positive. However, long-term progestin treatment may lead to resistance. We have studied the progestin resistance phenotype that frequently develops in endometrial...

Neovascularization is essential for tumor growth and metastasis. An adequate vasculature feeds tumor growth and enhances the potential of metastasis. For many years, tumor vessels were thought to be lined exclusively by endothelial cells (ECs). However, therapeutic benefits from the promising antiangiogenic strategy targeting genetically stable ECs...

A few highly aggressive and malignant tumor cells could acquire identities by turning on genes expressed by endothelial cells and recruit blood vessels to sustain tumor growth. Hypoxia was reported recently to play an essential role in these events. These 'plastic' tumor-cell phenotypes and the exact mechanism driving transendothelial differentiati...
SJTU-ParisTech Elite Institute of Technology The SJTU – ParisTech Elite Institute of Technology (SPEIT) brings together the strengths of leading French Grandes Ecoles (Ecole Polytechnique, Mines ParisTech, Telecom ParisTech, ENSTA ParisTech) and of Shanghai Jiao Tong University to develop Sino-French research and innovation collaboration and to educate high-potential Chinese and international students to become industrial leaders and innovators with: • a broad-based scientific background • the ability to evolve in a multicultural business environment • a forefront knowledge in one specialty field: Information and Communication Technology, Mechanical Engineering and Power and Energy Engineering. SPEIT enrolled its first students in 2012. In 2013, SPEIT was inaugurated by preceding French President, Mr François Hollande. In 2015, it got the accreditation of French Commission des Titres d’Ingénieurs and EUR-ACE: SPEIT graduates are awarded French titre d’ingénieur, which is internationally acknowledged as an equivalent to a Master in Engineering Science. In June 2016, SPEIT was granted an excellent Sino-French collaboration award by Chinese Vice-Prime Minister and French Minister of Education.
Department of Physical Education Established in 1986, the Physical Education Department of Shanghai Jiao Tong University is directly affiliated to the university. After more than 30 years of development, it has one first-level discipline authorized to offer master degree. There are 82 faculty members including 5 professors, 2 chair professors and 1 academic leader. It has been continuously awarded the "Presedent Cup" for seven times in national university games. The Department focuses on talent cultivation since the very beginning. By adhering to the "four combinations", the department will take teaching as the core, mass sport as the foundation, competition as the highlight and scientific research as the driving force. It will work actively to build the first-level platform with the characteristics of SJTU to cultivate talents by physical education.
To investigate the correlation of hypoxia-inducible factor (HIF)-1alpha and vascular endothelial growth factor (VEGF) or micro-vessel density (MVD). The ovarian cancer cell line SKOV3 was transplanted into nude mice to form xenogeneic tumor. Mice were treated with rapamycin 4 mg/kg, sulindac 100 mg/(kg.d) and saline 200 microl respectively. Express...
To investigate the inhibitory effects of Snail--a zinc finger transcription factor, anti-sense plasmid on the invasion of ovary carcinoma cell lines in vitro. Four human ovarian carcinoma cell lines ES-2, OVCAR3, HO8910, HO8910PM were analyzed for the expression of Snail and E-cadherin mRNA by RT-PCR. Then anti-Snail plasmid transfection was introd...
... Temserolimus was FDA approved for the treatment of advanced renal cell carcinoma in 2007 and is currently being evaluated in several clinical trials for its use in the treatment of gynecologic malignancies, including ovarian carcinoma.[28] Cell culture studies [10,293031 and mouse models323334353637 also suggested that PI3K pathway inhibitors are efficient in suppressing ovarian cancer cell growth. We analyzed the effect of the PI3K, AKT and mTORC1 inhibitors LY294002, SH-6 and rapamycin, respectively, on ovarian cancer cell growth using established cell lines and fresh human tumor tissue. ...

The Minhang campus is located in the Minhang District on the outskirts of metropolitan Shanghai. This young campus, which was founded in 1987, covers 2,822,903m2 once farmland. Zizhu Science Park, where Intel, ST Microelectronics, Microsoft, Sandisk and other high-tech companies placed their research and development centers, to the south of this campus.
Jiaozuo is noted for its blast furnaces and machine construction industries. The total GDP of the city in 2017 was 234.28 billion yuan, an increase of 7.4% over the previous year. Among them, the added value of the primary industry was 13.733 billion yuan, up 4.6%; the added value of the secondary industry was 13.841 billion yuan, up 6.7%; the added value of the tertiary industry was 81.143 billion yuan, up 9.1%. The per capita GDP reached 65,936 yuan. The three industrial structures changed from 6.4:59.3:34.3 of 2016 to 5.9:59.5:34.6.link
In 1945, after the defeat of the Japanese in the Second World War, he returned his hometown and joined a militia. He once took part in the battle of liberating Boshan District. Jiao Yulu joined the Communist Party of China in January 1946, and he soon was transferred to Bohai, Shandong and appointed a group leader of the Land Reform movement. By late Chinese Civil War, he worked in Weishi County, Henan province until 1951. In June 1953, he was transferred to Luoyang Mine Machine Manufacturing Plant and worked there until 1962.
School of Aeronautics and Astronautics The School of Aeronautics and Astronautics (SAA) is the main body of SJTU to cultivate talents for aerospace. The school consist of 3 departments and 2 research centers, namely, Department of Aircraft Design, Department of Aerospace Information and Control, Department of Propulsion, Near Space Research Center and J.C. Wu Center of Aerodynamics. Currently, SAA has more than 60 faculty members, 15 professors/researchers, 28 associate professors/associate researchers, which includes 2 Academician of the Chinese Academy of Engineering, 3 National “1000 Plan” Scholars, 2 Cheung Kong Professor. The school has 72 Doctoral Candidates, 205 Master Candidates, 112 Undergraduate students and 38 international students. SAA has maintained close and wide-ranging research cooperation and academic exchanges with many famous overseas universities and research institutions. The school also engages in visionary research projects to meet future demands and train highly qualified aerospace professionals for the future development of the world’s aerospace industry.
To investigate the inhibitory effects of Snail--a zinc finger transcription factor, anti-sense plasmid on the invasion of ovary carcinoma cell lines in vitro. Four human ovarian carcinoma cell lines ES-2, OVCAR3, HO8910, HO8910PM were analyzed for the expression of Snail and E-cadherin mRNA by RT-PCR. Then anti-Snail plasmid transfection was introd...
Gankyrin has been implicated in the formation of multiple cancer types, although its roles in estrogen-driven endometrial carcinoma remain unclarified. We evaluated the expression of Gankyrin in endometrial tissues and further explored its roles in estrogen-driven and GPR30-mediated endometrial cancer cell proliferation. Gankyrin was overexpressed...
p53 is the most commonly mutated tumor suppressor gene in human cancers. In addition to the loss of tumor suppression function and exertion of dominant-negative effects over the remaining wild-type protein, several p53 mutants can gain novel oncogenic functions (gain-of-function, GOF) that actively regulate cancer development and progression. In hu...

Ovarian cancer is the most lethal malignancy of the female reproductive system with an overall mortality rate of greater than 70%. Our group has demonstrated that Follicle stimulating hormone (FSH) stimulates the proliferation and invasion of ovarian cancer cells, inhibits apoptosis, and facilitates neovascularization by increasing expression of va...
School of Naval Architecture, Ocean and Civil Engineering The School of Naval Architecture, Ocean and Civil Engineering (NAOCE) has a strong tradition of excellence and is comprised of five departments: naval architecture and ocean engineering, engineering mechanics, civil engineering, architecture, and transportation and shipping logistics. It is the home of the State Key Laboratory of Ocean Engineering and the Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration. The naval architecture and ocean engineering program has been ranked No. 1 in 2017 Shanghai Ranking’s Global Ranking of Academic Subjects. The School also features two state key disciplines (Naval Architecture and Ocean Engineering; Mechanics). The School has 224 faculty members, including 78 professors and 90 associate professors. Among them, there are seven academicians of CAS and CAE, eight Thousand Talents Plan experts, six MOE Cheung Kong Scholars, and two NSFC distinguished young researchers.
Objective To assess the effect of 17β-estradiol(E2) on cell proliferation, cell invasiveness and its regulation of MTA3, Snail and matrix metalloproteinase 2 (MMP-2) expression in the ovarian clear cell adenocarcinoma cell line ES2, and to further investigate the mechanism involved. Methods We first investigated expression of ERα, ERβ, PR and E-cad...
Ovarian clear cell adenocarcinoma (OCCA) is an aggressive ovarian malignancy with a poor prognosis. The role of estrogen receptor β (ERβ) in the development of OCCA remains to be clarified. To investigate the action of ERβ in the proliferation and invasion of OCCA cells, the ES-2 cell line was stably transfected with full-length human ERβ cDNA, and...
Objective To study the expression of intermediate? conductance? Ca2+-activatedK+ (KCa3.1) channelsin Endometrial cancer tissues and their role in regulating cell cycle of endometrial cancer cells.Methods Real?time PCR and Western blotting analysis were used to examine the expression of KCa3.1 channels in 25 normal endometrial specimens,26 atypical...
Shortly after his marriage to Feng Heng, Huang Yaoshi met Wang Chongyang's junior, Zhou Botong. He learnt from Zhou Botong that Wang Chongyang had died and that Zhou had inherited the Nine Yin Manual. He wanted the book for himself so he tricked Zhou Botong into allowing his wife to read it. Zhou Botong agreed and let her read the second volume of the manual. Feng Heng had eidetic memory so she memorised the book easily. She lied to Zhou Botong that the manual was fake and that it was actually a copy of a book of childish rites she had memorised by heart. She recited the first few verses of the manual verbatim to Zhou Botong, who mistakenly believed her and destroyed the book in anger. After Zhou Botong left, Feng Heng wrote a copy of the manual from memory for her husband.
China Europe International Business School China Europe International Business School (CEIBS), a joint-venture for management education, was co-founded by the Chinese government and European Union (EU) in 1994, with Shanghai Jiao Tong University and the EFMD serving as its executive partners. As China's only business school to originate from government-level collaboration, CEIBS is committed to educating responsible leaders versed in "China Depth, Global Breadth" in line with its motto of "Conscientiousness, Innovation and Excellence". Leaders from the Chinese central government and the EU have respectively lauded CEIBS as "a cradle of excellent executives" and "a role model of EU-China cooperation". CEIBS offers MBA, EMBA, Global EMBA, Finance MBA and Executive Education programmes. Renowned for its academic rigour, CEIBS is the first business school on the Chinese mainland to have been accredited by both EQUIS and AACSB and the only business school in Asia to have simultaneously made it to the Financial Times' top 30 list of MBA, EMBA and Executive Education programmes.
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