RAB25 belongs to the Rab family of small GTPases and is implicated in the development of various types of human cancer. To evaluate the role of RAB25 in ovarian cancer, RAB25 was knocked down by siRNA in HEY and ES‑2 human ovarian cancer cells. Autophagy, cell growth and cell apoptosis were evaluated. The results showed that knockdown of RAB25 incr...
To express tumor necrosis factor related apoptosis inducing ligand (TRAIL) protein using endothelial progenitor cell (EPC) and observe antitumor activity of secreted TRAIL in cell culture supernatant. EPC were isolated by immunomagnetic sorting. Human TRAIL plasmid was transfected into EPC by lipofectamine 2000. The cell culture supernatant was har...
Objective: To investigate the chemosensitivity of ovarian cancer SK-OV-3ip1 multicellular aggregates (MCA) to cisplatin and taxol and to explore the possible mechanisms. Methods: Liquid overlay system was employed to obtain MCA. We detected the resistance using trypan blue exclusion testing, clonogenic assay, cell cycle profiles and apoptosis with...

NANOG is a key transcription factor that is overexpressed and plays an important role in various cancers. Its overexpression is associated with highly tumorigenic, drug-resistant, and poor prognosis. However, the underlying mechanism of action of NANOG in ovarian cancer remains unclear. Epithelial-mesenchymal transition (EMT), which is a critical p...
The aim of present study was to investigate the role of preoperative neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) used as prognostic markers for predicting chemotherapeutic response and survival outcomes in patients with epithelial ovarian cancer (EOC) who are receiving platinum-based chemotherapy. A total of 344 pati...
To assess the estrogen and progestin's effect on protein expression of metastasis repression gene nm23-H1 via regulation of phosphorylation signaling in epithelial ovarian cancer cell line ES-2. Ovarian clear cell adenocarcinom cell line ES-2 was treated by different doses of 17beta-estradiol (estrogen), medroxyprogestogen (progestin) and dimethyl...
To make the competition for his daughter's hand-in-marriage a fair one, Huang Yaoshi sets a series of three tests for the two contestants: Guo Jing and Ouyang Ke. The first obstacle is a test of martial arts. Ouyang Feng spars with Guo Jing while Hong Qigong fights Ouyang Ke. Guo Jing wins the first bout but ties with Ouyang Ke in the subsequent round, which involves appreciation of a piece of music played by Huang Yaoshi. The last assessment is a test of memory, in which Huang Yaoshi produces an incomplete copy of the Nine Yin Manual, without identifying the book, and asks the two contestants to memorise the text and recite to him later. Guo Jing read the manual before so he recites fluently and defeats Ouyang Ke.
Although glycogen synthase kinase-3 (GSK-3) might act as a tumor suppressor since its inhibition is expected to mimic the activation of Wnt-signaling pathway, GSK-3beta may contribute to NF-kappaB activation in cancer cells leading to increased cancer cell proliferation and survival. Here we report that GSK-3beta activity was involved in the prolif... 

Ovarian epithelial cancer is the leading cause of death among gynecological malignancies. FSH may increase the risk of ovarian malignancy and play an important role in ovarian carcinogenesis. Our previous studies showed that FSH increases the expression of VEGF through survivin. In this study, the function and mechanism of FSH in ovarian cancer wer...
Gankyrin has been implicated in the formation of multiple cancer types, although its roles in estrogen-driven endometrial carcinoma remain unclarified. We evaluated the expression of Gankyrin in endometrial tissues and further explored its roles in estrogen-driven and GPR30-mediated endometrial cancer cell proliferation. Gankyrin was overexpressed...
Recent studies have suggested that follicle-stimulating hormone (FSH) plays an important role in ovarian epithelial carcinogenesis. We demonstrated that FSH stimulates the proliferation and invasion of ovarian cancer cells, inhibits apoptosis, and facilitates neovascularisation. Our previous work has shown that transient receptor potential channel... 

Huang Yaoshi is a fictional character in the wuxia novel The Legend of the Condor Heroes and its sequel, The Return of the Condor Heroes, by Jin Yong. He is one of the Five Greats of the wulin (martial artists' community) during the Song dynasty, alongside Wang Chongyang, Hong Qigong, Ouyang Feng and Duan Zhixing. He is nicknamed "Eastern Heretic" (東邪) for being an unorthodox radical who behaves as he wishes without showing any regard for formalities or moral ethics.[SheDiao Ch.10] He loathes the dogma of traditional rites in Chinese society and admires only genuine honour and pure love.[SheDiao Ch.10] As such, he is often regarded by his contemporaries as a cultural heretic.[SheDiao Ch.10] His nickname may be translated to "Eastern Evil" because the character Xie (邪) in his nickname also refers to "evil" and "unorthodoxy" in jianghu terminology.
Epithelial ovarian cancer (EOC) remains the most lethel gynecological malignancy. In the absence of an effective screening strategy, two thirds of patients are diagnosed in advanced clinical stage. Despite chemotherapy with cisplatin and paclitxel, primary or acquired chemoresistance faciltates survival of cancer cells, resulting in disease recurre...

School of Pharmacy SJTU School of Pharmacy was founded in 2000, and now it has 85 academic, administrative and technical staff members. The School has 17 research and teaching laboratories covering the complete spectrum of curriculum and disciplines of pharmacy education and research including medicinal chemistry, pharmacology, pharmaceutics, pharmaceutical microbiology & biochemistry, pharmacognosy, and traditional Chinese medicine. SJTU School of Pharmacy is a research-orientated institution. Its graduate student body, enrolled in Ph.D., M.Sc. and M.Eng. programs, is as twice larger as its undergraduate classes. Both of the undergraduate and graduate courses are given by individual research laboratories each consisting of a professor and two to four junior academic staffs. SJTU School of Pharmacy has not only developed scientific programs but also nurtured an educational and research environment that is liberal and innovation-orientated. The school has now become a leading institute and an ideal place for pharmacy education and pharmaceutical research in the nation.
Objective: This research was carried out to investigate the effectiveness, rationality, and safety of laparotomy management compared with uterine artery embolization (UAE) combined with methotrexate (MTX) for the treatment of deep implantation cesarean scar pregnancy (CSP II). Materials and methods: Data from 29 patients seen between June 2008 and...

... With respect to other cancers, lithium has been found to be lethal to neuroblastoma cells but not to normal nerve cells (11). A similar effect was found in ovarian cancer cells (12), although a subsequent similar study on ovarian cancer cells suggests only a more modest benefit (13). It is not clear from our reading of the two ovarian cancer papers why the results are significantly different from each other. ...


Objective: To investigate the expression of P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) and the relationship with cell cycle profiles in ovarian cancer SK-OV-3ip1 multicellular aggregates. Methods: Liquid overlay system was employed to obtain multicellular aggregates. Expression of P-gp and MRP was detected with flow cyt...
To express tumor necrosis factor related apoptosis inducing ligand (TRAIL) protein using endothelial progenitor cell (EPC) and observe antitumor activity of secreted TRAIL in cell culture supernatant. EPC were isolated by immunomagnetic sorting. Human TRAIL plasmid was transfected into EPC by lipofectamine 2000. The cell culture supernatant was har...
Research in autophagy continues to accelerate,(1) and as a result many new scientists are entering the field. Accordingly, it is important to establish a standard set of criteria for monitoring macroautophagy in different organisms. Recent reviews have described the range of assays that have been used for this purpose.(2,3) There are many useful an...
Henan Polytechnic University (HPU)[1], with a history of nearly 100 years, is the first mining university in Chinese history. Its former is Jiaozuo Coal Mining School which was established by the British Syndicate Co. Ltd., in 1909. It has changed its names several times in the course of development, namely, FuZhong Coal Mining University, Jiaozuo Private Institute of Technology, North-west Institute of Technology, Jiaozuo National Institute of Technology, Jiaozuo Mining Institute and Jiaozuo Institute of Technology. The University resumed its name of Henan Polytechnic University in 2004.
Ovarian cancer causes more deaths than any other type of female reproductive cancer. The development of new therapeutic approaches is required due to the low survival rate using routine methods. The goal of this study was to investigate the effect of the gene silencing of mediator complex subunit 19 (MED19) on cell viability and tumor growth in ova...

We previously showed that the expressing level of FSH receptor (FSHR) increased from ovarian epithelial inclusions (OEIs) to benign ovarian epithelial tumors (OETs) and to borderline OETs, whereas FSHR levels decreased with an increase in carcinoma grade. The aim of this study was to investigate the role of FSHR in OET development. MCV152 cells wit...

Ovarian cancer is the most lethal malignancy of the female reproductive system with an overall mortality rate of greater than 70%. Our group has demonstrated that Follicle stimulating hormone (FSH) stimulates the proliferation and invasion of ovarian cancer cells, inhibits apoptosis, and facilitates neovascularization by increasing expression of va...
To make the competition for his daughter's hand-in-marriage a fair one, Huang Yaoshi sets a series of three tests for the two contestants: Guo Jing and Ouyang Ke. The first obstacle is a test of martial arts. Ouyang Feng spars with Guo Jing while Hong Qigong fights Ouyang Ke. Guo Jing wins the first bout but ties with Ouyang Ke in the subsequent round, which involves appreciation of a piece of music played by Huang Yaoshi. The last assessment is a test of memory, in which Huang Yaoshi produces an incomplete copy of the Nine Yin Manual, without identifying the book, and asks the two contestants to memorise the text and recite to him later. Guo Jing read the manual before so he recites fluently and defeats Ouyang Ke.
Luteinizing hormone (LH) plays an important role in the development of ovarian cancer, and has been shown to inhibit apoptosis in ovarian cancer cells. Similarly, survivin is a molecule that has been shown to inhibit apoptosis in other types of cancer. Therefore, the aim of this study was to determine whether survivin can be induced by LH in ovaria...
Antai College of Economics and Management Antai College of Economics and Management (ACEM), Shanghai Jiao Tong University boasts a rich history and tradition which dates back to the Business School of Nan Yang Public School founded in 1903. ACEM is dedicated to educate economic and management talents with international competencies. It promotes scientific and academic innovation, caters to economic and social development, and supports the growth of business. After over 30 years’ unremitting efforts, ACEM has established itself as a modern business school with a good reputation home and abroad, and the first business school in mainland China to have been triply accredited by AACSB, EQUIS and AMBA, the three largest and most influential business school accreditation associations in the world.
To investigate the involvement of estrogen receptor (ER) beta in the proliferation of ovarian clear cell adenocarcinoma by restoring ERbeta expression in a cell line ES-2. A plasmid with full length ERbeta cDNA, pRSV-ERbeta and its negative vector control pRSV were introduced into ES-2. The cells transfected were named according to the plasmids: ES...
IQGAP1 is a scaffolding protein and overexpressed in many human tumors, including ovarian cancer. However, the contribution of IQGAP1 to invasive properties of ovarian cancer cells remains unknown. Here, we investigated the effect of IQGAP1-specific short hairpin RNA (shRNA) expressing plasmids on metastatic potential of ovarian cancer HO-8910PM ce...
... Interestingly, estradiol may play a dual role in modulating NRF2 activity. On the one hand, its metabolites activate NRF2 via the generation of reactive oxygen species (ROS) (independent of the ER) [29]. While recent studies demonstrated that estradiol leads to an activation of NRF2 in a wide range of cell types [30,31], the estradiol effect was only noted on protein and not on mRNA levels, suggesting that the main effect of estradiol is based on NRF2 protein stabilization [32]. ...
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