We previously showed that the expressing level of FSH receptor (FSHR) increased from ovarian epithelial inclusions (OEIs) to benign ovarian epithelial tumors (OETs) and to borderline OETs, whereas FSHR levels decreased with an increase in carcinoma grade. The aim of this study was to investigate the role of FSHR in OET development. MCV152 cells wit...

Progestin is an effective endocrine treatment for patients with atypical hyperplasia or with endometrial carcinoma that is estrogen receptor (ER) positive and progesterone receptor (PR) positive. However, long-term progestin treatment may lead to resistance. We have studied the progestin resistance phenotype that frequently develops in endometrial...
A cultural events package for the international student community at JI, including excursions into the environs of Shanghai, martial arts, Chinese cuisine and similar classes as well as cultural and social events is strongly recommended to be taken by all students at JI. The cost for the whole package is 2,500 RMB and must be paid in advance of coming to JI.
Human homeobox gene (HOX) A10 is a homeobox allotype gene of the HOXA family in the HOX family. Human homeobox gene A10 may play an important role in cancer development. However, the role of HOXA10 in the carcinogenesis of ovarian clear cell adenocarcinoma (OCCA) has not been established. We have evaluated the prognostic significance of HOXA10 expr...
Objective: To detect mRNA levels and expression of CD44, CD54, CD29 and E-cadherin (E-cad) and to discuss their relationship with formation and drug resistance of ovarian cancer SKOV3ip1 multicellular aggregates. Methods: Liquid overlay system was employed to obtain multicellular aggregates. mRNA levels and expression of CD44, CD54, CD29 and E-cad...
Although glycogen synthase kinase-3 (GSK-3) might act as a tumor suppressor since its inhibition is expected to mimic the activation of Wnt-signaling pathway, GSK-3beta may contribute to NF-kappaB activation in cancer cells leading to increased cancer cell proliferation and survival. Here we report that GSK-3beta activity was involved in the prolif...
Most buildings on campus were influenced by American architecture, while the main gate, which was built in 1935, is of traditional Chinese style reflecting the University's earlier status as the "Imperial Polytechnic College". The approaches to the main gate were via a series of marble bridges, similar to, although smaller than, those built in front of Tiananmen. However, recent road expansions have demolished the river as well as most of bridges. A copy of this famous gate scene have been built on the east of Minhang campus.
Huang Yaoshi later regrets bitterly for inflicting such a heavy punishment on his innocent apprentices. He sets off to find his daughter, who has left home after quarrelling with her father. He meets Mei Chaofeng at Guiyun Manor on Lake Tai, where Lu Chengfeng has settled down. He agrees that Mei Chaofeng has been duly punished since she has lost her sense of sight and her husband. He forgives her and asks her to find his other apprentices and bring them back to the manor so he can heal their legs. However, he never saw his other apprentices again: Chen Xuanfeng was killed by Guo Jing; Qu Lingfeng was killed by Shi Yanming; Wu Mianfeng died of illness; Feng Mofeng has become a blacksmith and is killed by Jinlun Guoshi in the sequel. Huang Yaoshi later accepts Lu Chengfeng's son, Lu Guanying, and Qu Lingfeng's daughter, Shagu, as his grand-apprentices.
Genistein, the most abundant phytoestrogen in soybeans, may bind to estrogen receptors and perform anticancer activities. Choriocarcinoma is a malignant, trophoblastic and aggressive cancer of the placenta. Few studies are currently available concerning the effects of genistein on choriocarcinoma. In the present study, we investigated the effect of...

Jiaozuo (Chinese: 焦作; pinyin: Jiāozuò [tɕjáu.tswô]; postal: Tsiaotso) is a prefecture-level city in northern Henan province, China. Sitting on the northern bank of the Yellow River, it borders the provincial capital of Zhengzhou to the south, Xinxiang to the east, Jiyuan to the west, Luoyang to the southwest, and the province of Shanxi to the north.Jiaozuo is one of the core cities of the Central Plains urban agglomeration and a regional central city in the Jin-Yu border area.link


Our previous studies have showed that Gankyrin expression is correlated with a malignant phenotype in endometrial carcinoma. Here, we investigated the possible role of Gankyrin in cervical disease. The increasing protein level of Gankyrin was observed in high-grade cervical intraepithelial neoplasia and carcinoma compared with benign cervical tissu...


... Interestingly, estradiol may play a dual role in modulating NRF2 activity. On the one hand, its metabolites activate NRF2 via the generation of reactive oxygen species (ROS) (independent of the ER) [29]. While recent studies demonstrated that estradiol leads to an activation of NRF2 in a wide range of cell types [30,31], the estradiol effect was only noted on protein and not on mRNA levels, suggesting that the main effect of estradiol is based on NRF2 protein stabilization [32]. ...


Golgi phosphoprotein 3 (GOLPH3), a newly recognized oncogene, is associated with tumor growth, metastasis, and poor prognosis in several types of cancer. However, its biological role and underlying mechanism in epithelial ovarian cancer (EOC) remain poorly understood. Here, we found that GOLPH3 was overexpressed in EOC tissues and cell lines. This...

Huang Yaoshi is a fictional character in the wuxia novel The Legend of the Condor Heroes and its sequel, The Return of the Condor Heroes, by Jin Yong. He is one of the Five Greats of the wulin (martial artists' community) during the Song dynasty, alongside Wang Chongyang, Hong Qigong, Ouyang Feng and Duan Zhixing. He is nicknamed "Eastern Heretic" (東邪) for being an unorthodox radical who behaves as he wishes without showing any regard for formalities or moral ethics.[SheDiao Ch.10] He loathes the dogma of traditional rites in Chinese society and admires only genuine honour and pure love.[SheDiao Ch.10] As such, he is often regarded by his contemporaries as a cultural heretic.[SheDiao Ch.10] His nickname may be translated to "Eastern Evil" because the character Xie (邪) in his nickname also refers to "evil" and "unorthodoxy" in jianghu terminology.
... Mediator complex subunit 19 (MED19) is a member of the mediator that has a key role in the activation and repression of signal transduction or the regulation of transcription in carcinomas ( Casamassimi and Napoli, 2007;Sun et al, 2011). Accumulating evidence has shown that MED19 has important roles in cancer cell proliferation and tumorigenesis, and suppression of MED19 expression induces inhibition of cell proliferation and tumorigenesis in several different tumour types including lung cancer, pancreatic cancer, ovarian cancer and breast cancer ( Liu et al, 2012;Wei et al, 2015). Then we speculated that miR-214 played tumorigenic role by its target MED19 in CRC. ...
The Ministry of Commerce assumed administration of the college in 1904, and in 1905 changed the college's name to Imperial Polytechnic College of the Commerce Ministry. In 1906, the college was placed under the Ministry of Posts and Telegraphs, and its name was changed to Shanghai Industrial College of the Ministry of Posts and Telegraphs. When the Republic of China was founded, the college was placed under the Ministry of Communications and its name was once again changed, this time to Government Institute of Technology of the Communications Ministry.
To assess the estrogen and progestin's effect on protein expression of metastasis repression gene nm23-H1 via regulation of phosphorylation signaling in epithelial ovarian cancer cell line ES-2. Ovarian clear cell adenocarcinom cell line ES-2 was treated by different doses of 17beta-estradiol (estrogen), medroxyprogestogen (progestin) and dimethyl...

To observe whether endothelial cell (EC) progenitors (CD(34)(+)-positive mononuclear cells) participated in neovasculogenesis of ovarian epithelial carcinoma through in vitro and in vivo experiments, and to explore the mechanism of tumor neovasculogenesis. CD(34)(+)-positive mononuclear cells were isolated from peripheral blood of ovarian epithelia...


... [9,25] Overall, the main reasons reported contributing to the psychosocial burden among women (anxious, fearful, self-blame, powerlessness, disbelief, depression, and anger) in this domain were lack of understanding of abnormal Pap smear results and higher perceived risk of developing cervical cancer which also have negative impact on perception of self. [10,11,26] Domain 3: Worry about human papillomavirus infectivity Women of reproductive age were found to have a significantly higher mean score not only in general but also in both individual items of this domain " worry about HPV infectivity " compared to a menopausal group of women. Our results were quite similar to the study conducted in the United States which reported that women with abnormal Pap smear results were distressed due to a sense of shame or guilt when they came to know that these cervical changes are associated with HPV and which is a sexually transmitted infection. ...
School of Naval Architecture, Ocean and Civil Engineering The School of Naval Architecture, Ocean and Civil Engineering (NAOCE) has a strong tradition of excellence and is comprised of five departments: naval architecture and ocean engineering, engineering mechanics, civil engineering, architecture, and transportation and shipping logistics. It is the home of the State Key Laboratory of Ocean Engineering and the Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration. The naval architecture and ocean engineering program has been ranked No. 1 in 2017 Shanghai Ranking’s Global Ranking of Academic Subjects. The School also features two state key disciplines (Naval Architecture and Ocean Engineering; Mechanics). The School has 224 faculty members, including 78 professors and 90 associate professors. Among them, there are seven academicians of CAS and CAE, eight Thousand Talents Plan experts, six MOE Cheung Kong Scholars, and two NSFC distinguished young researchers.
To elucidate the mechanisms of nuclear estrogen receptor (ER)-mediated and G protein-coupled receptor 30 (GPR30)-mediated signaling in the regulation of proliferation in ER-positive and ER-negative endometrial cancer cells, two human endometrial carcinoma cell lines, Ishikawa (ER-positive) and KLE (ER-negative), were used. PCR and Western blot anal...
IQGAP1 is a scaffolding protein and overexpressed in many human tumors, including ovarian cancer. However, the contribution of IQGAP1 to invasive properties of ovarian cancer cells remains unknown. Here, we investigated the effect of IQGAP1-specific short hairpin RNA (shRNA) expressing plasmids on metastatic potential of ovarian cancer HO-8910PM ce...

To assess the clinical features and prognostic factors of malignant ovarian teratoma. Eighty-four patients with malignant ovarian teratoma between 1954 and 2001 were studied retrospectively. All patients were treated with surgery, the mid-period of follow-up was 146 months. Patient characteristics, surgical therapy, pathologic diagnosis, histologic...


To compare the therapeutic and toxic profile of topotecan given intraperitoneally with intravenously in human ovarian cancer xenografted into athymic nude mice. Eighty female Balb-c/nu-nu mice were randomized assigned into eight groups (n=10). Xenografts resulted from intramesentery injection of cultured human ovarian cancer cells SKOV3 in athymic...
×