p53 is the most commonly mutated tumor suppressor gene in human cancers. In addition to the loss of tumor suppression function and exertion of dominant-negative effects over the remaining wild-type protein, several p53 mutants can gain novel oncogenic functions (gain-of-function, GOF) that actively regulate cancer development and progression. In hu...
Huang Yaoshi is married to Feng Heng and has six apprentices. He has scores of servants on his island, who are deaf and mute. Rumours in the jianghu say that he intentionally disabled them, but in fact, they were already mute and deaf before they became his servants. He recruited them as his servants to relieve them from the social stigma of their impairments so that they can enjoy a better life on his island. However, he does not wish to promote an image of himself as a kind and compassionate person so he spread those negative rumours about himself. Only his family and apprentices know the truth.
When the Japanese surrendered in 1945, neither the Communist Party of China (CPC) nor the Kuomintang KMT trusted each other or were actively cooperating. After American-sponsored attempts to negotiate a coalition government failed in 1946, the Chinese Civil War resumed. The CPC defeated the Nationalists in 1949, forcing Chiang's government to retreat to Taiwan. During the evacuation, a part of faculty and alumni was taken to Taiwan by Chiang Kai-shek, founding National Chiao Tung University in Taiwan in 1958.
Ovarian cancer is the most lethal malignancy of the female reproductive system with an overall mortality rate of greater than 70%. Our group has demonstrated that Follicle stimulating hormone (FSH) stimulates the proliferation and invasion of ovarian cancer cells, inhibits apoptosis, and facilitates neovascularization by increasing expression of va...
Ovarian carcinoma is leading cause of death in gynecologic malignancies. The survival rate cannot be improved after routine surgery, chemotherapy, and radiotherapy. Therefore biotherapy becomes the fourth treatment pattern for ovarian carcinoma. Adequate experimental models for the development of biologic therapeutic strategies are needed. Our purp...
Ovarian epithelial cancer is the leading cause of death among gynecological malignancies. FSH may increase the risk of ovarian malignancy and play an important role in ovarian carcinogenesis. Our previous studies showed that FSH increases the expression of VEGF through survivin. In this study, the function and mechanism of FSH in ovarian cancer wer...

Jiao Yulu was born in Yuanquan Town of Boshan District, in Zibo city, in Shandong province, to a poor family, on August 16, 1922, during the Republic of China.[3] Both his father Jiao Fangtian (焦方田) and mother were farmers.[3] He had only four years of schooling.[3] His father hanged himself during the Second Sino-Japanese War.[3] Jiao Yulu was conscripted into the Japanese labor and he was sent to coal-mining in Fushun, Liaoning, Manchoukuo.[3] He escaped to Suqian, Jiangsu in the fall of 1943.[3] He had been a farm labourer for two years for the landowner Hu Tairong (胡泰荣).[3]


School of Mathematical Sciences The School of Mathematical Sciences (SMS) enjoys a rich history dating back to the establishment of Department of Mathematics in 1928, 32 years after the founding of the university. One evidence of its place in modern mathematics in China is that the first Congress of the Chinese Mathematical Society was held in 1935 at SJTU. In 2014, the Department of Mathematics was selected by the central government as one of the first four Model Schools for Internationalization, which encourages us to be more internationalization in its practices, vision and outlook. With the growth in size, it was reorganized into the School of Mathematical Sciences in December 2015. With more than 100 faculties members, the school now consists of 3 departments (Mathematics, Applied and Computational Mathematics, and Statistics) and 1 center (Research Center for Mathematics Education).
School of Biomedical Engineering The School of Biomedical Engineering (BME) aims to satisfy the major needs of global development and meet the demand for interdisciplinary programs between medicine, science, and engineering. Based on the current frontiers of international research, major national needs, interdisciplinary programs, and the existing foundation of SJTU, BME consists the following six disciplines: Biomedical Instrumentation, Neuroscience and Engineering, Medical Imaging & Informatics, Nano-biomaterials, Systems Biology & Medicine, and Biological Sciences & Diseases. BME has been dedicated in cultivating high-level research, development, and management talents that are internationally competitive in the field of biomedical engineering.
Ovarian clear cell adenocarcinoma (OCCA) is an aggressive ovarian malignancy with a poor prognosis. The role of estrogen receptor β (ERβ) in the development of OCCA remains to be clarified. To investigate the action of ERβ in the proliferation and invasion of OCCA cells, the ES-2 cell line was stably transfected with full-length human ERβ cDNA, and...
When the Japanese surrendered in 1945, neither the Communist Party of China (CPC) nor the Kuomintang KMT trusted each other or were actively cooperating. After American-sponsored attempts to negotiate a coalition government failed in 1946, the Chinese Civil War resumed. The CPC defeated the Nationalists in 1949, forcing Chiang's government to retreat to Taiwan. During the evacuation, a part of faculty and alumni was taken to Taiwan by Chiang Kai-shek, founding National Chiao Tung University in Taiwan in 1958.
A few highly aggressive and malignant tumor cells could acquire identities by turning on genes expressed by endothelial cells and recruit blood vessels to sustain tumor growth. Hypoxia was reported recently to play an essential role in these events. These 'plastic' tumor-cell phenotypes and the exact mechanism driving transendothelial differentiati...
... In vEDS cells, an ER perturbation was suggested by the abnormal ER distribution of the protein disulfide isomerase enzyme and by reduced expression of FKBP22, an ER resident peptidyl-prolyl cis-trans-ER isomerase involved in the folding of COLLIII triple helix [108,139,140]. Since the perturbed ER redox state may influence the down-regulation of Bcl-2 and the activation of the caspase-dependent apoptosis [141], and FKBP22 can have an anti-apoptotic role acting on the expression of Bcl-2 and caspases [142], this aspect merits further studies in vEDS fibroblasts. ...
KoGuan Law School Legal education at Shanghai Jiao Tong University can be traced back to special and political classes during the period of Nanyang College in September 1901. However, it was interrupted during the education reform in 1950s until the Law School was re-established on June 8 2002. The law School received the new title “KoGuan School of Law” in 2008 in memorial of the generous donation of Professor Leo KoGuan. KoGuan School of Law has a strong, well-structured and international team of faculty, including 65 full-time faculty members. A variety of research centers within the law school has produced high quality scholarship covering a wide range of fields and disciplines, from constitutional law to law and society, from maritime law to competition law, etc. KoGuan School of Law has explored its own style of educating a new generation of law students and future jurists, and established its own reputation in both academic and practical circles. For the time being, it offers a full-scale legal education system including LLB, LLM, JM, and PhD programs.
... The influence of E2 on iron metabolism as depicted in ▶ Fig. 1 has been attributed to its ability to reduce HAMP synthesis and maintain/enhance FPN expression in human breast (MCF-7) and ovarian (SKOV-3) cell lines [29][30][31]. Reduced HAMP synthesis in E2-treated human liver HuH7 and Hep-G2 cells was attributed to the binding of E2-ER to E2 responsive elements (EREs) in the HAMP gene [32,33]. Use of the E2 antagonist ICI 182,780 was shown to inhibit E2-induced downregulation of HAMP gene [33]. ...
To study the expression of glucose transporter-1 (GLUT1) and its correlation with basic fibroblast growth factor (bFGF) and proliferating cell nuclear antigen (PCNA) in epithelial ovarian neoplasm. Streptavidin-peroxidase complex technique was used to examine the expression of GLUT1, bFGF and PCNA protein in six cases of normal ovarian tissue, 20 c...
The construction of the campus never came to an end in the past century. Existing buildings: the Middle College building (built in 1898), the original library (built in 1919), the gymnasium (built in 1925), the administrative building (built in 1933), the Xinjian building (built in 1953), the new Upper College building (built in 1955), the second teaching building (built in 1960), Bao Zhaolong library (built in 1985) and Haoran high-tech building (built in 1996) were constructed one after another.
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