Objective: To investigate the expression of P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) and the relationship with cell cycle profiles in ovarian cancer SK-OV-3ip1 multicellular aggregates. Methods: Liquid overlay system was employed to obtain multicellular aggregates. Expression of P-gp and MRP was detected with flow cyt...

Progestin resistance is the main obstacle to successful conservative therapy in young endometrial cancer patients. To investigate the molecular events that lead to progestin resistance and to find a possible way to reverse progestin resistance in endometrial cancer, we established a progestin-resistant Ishikawa cell line by long-term progestin trea...


The construction of the campus never came to an end in the past century. Existing buildings: the Middle College building (built in 1898), the original library (built in 1919), the gymnasium (built in 1925), the administrative building (built in 1933), the Xinjian building (built in 1953), the new Upper College building (built in 1955), the second teaching building (built in 1960), Bao Zhaolong library (built in 1985) and Haoran high-tech building (built in 1996) were constructed one after another.

Since 2003, Shanghai Jiao Tong University has produced the Academic Ranking of World Universities[24] which analyzes the top universities in the world on quality of faculty (40%), research output (40%), quality of education (10%) and performance vs. size (10%).[25] Its ranking is exclusively of research universities, mainly in the empirical sciences.


... Previous studies have discovered high IKCal expressions in endometrial carcinoma, breast cancer, urinary bladder carcinoma, colon cancer, and glioblastoma cells. [4][5][6][7] This study demonstrated the close relationship between the Ca 2+ -activated K + channel and cervical cancer. [8,9] This study utilized the K + -channel blocker clotrimazole (CLT) and small hairpin ribonucleic acid (RNA) to explore the role played by (and the effect of) IKCal in the proliferation of HeLa cells. ...
Gestational diabetemellitus (GDM) is a condition whereby a mother's glucose tolerance is impaired with onset or first recognition during pregnancy which is not either type 1 or type 2 diabetes mellitus. Oxidative stress plays an essential role in diabetes, however, whether it also includes in GDM has not been fully clarified. Therefore, we investig...

To investigate the inhibitory effect of the mammalian target of rapamycin (mTOR) inhibitor, sirolimus on expression of hypoxia-inducible factor (HIF)1alpha protein and growth of ovarian carcinoma in an athymic mouse xenogeneic transplant model of ovarian cancer. Four groups of female nude mice were inoculated subcutaneously with SKOV3 cells. After...


UM-SJTU Joint Institute The UM-SJTU Joint Institute (JI) was jointly established in 2006 by two premier universities, the University of Michigan and Shanghai Jiao Tong University. The mission of JI is to build a world-class educational and research institute in China and foster future researchers and leaders with a global perspective. Abiding by the philosophy of “Internationalization, Interdisciplinary, Innovation, and Quality”, JI adopts curriculums blending the unique features of the two founding universities. Both of its undergraduate majors, Mechanical Engineering (ME) and Electrical & Computer Engineering (ECE), achieved the world’s most authoritative ABET accreditation. All courses are taught in English by world-class faculty recruited from global leading universities in the U.S. and other developed countries. Many are winners of prestigious awards such as Yangtze Scholar, 1000-talent Scholars, New Century Talents, Pujiang Scholars, and Shanghai Magnolia Gold and Silver Awards. JI has won many awards for higher education innovation, including the “Model of Chinese Higher Education Reform” from the Chinese State Council and the “Andrew Heiskell Award for Innovation in Higher Education” from the Institute of International Education, one of the most prestigious awards in international education.
... The influence of E2 on iron metabolism as depicted in ▶ Fig. 1 has been attributed to its ability to reduce HAMP synthesis and maintain/enhance FPN expression in human breast (MCF-7) and ovarian (SKOV-3) cell lines [29][30][31]. Reduced HAMP synthesis in E2-treated human liver HuH7 and Hep-G2 cells was attributed to the binding of E2-ER to E2 responsive elements (EREs) in the HAMP gene [32,33]. Use of the E2 antagonist ICI 182,780 was shown to inhibit E2-induced downregulation of HAMP gene [33]. ...
Chemoresistance is the major obstacle to cure endometrial cancer, whereas metformin has demonstrated sensitization to chemotherapy in endometrial cancer. A novel finding states that isocitrate dehydrogenase 1 (IDH1) involves in cancer chemoresistance. Recent studies have revealed that epigenetic modifications facilitate chemoresistance. However, wh...
To make the competition for his daughter's hand-in-marriage a fair one, Huang Yaoshi sets a series of three tests for the two contestants: Guo Jing and Ouyang Ke. The first obstacle is a test of martial arts. Ouyang Feng spars with Guo Jing while Hong Qigong fights Ouyang Ke. Guo Jing wins the first bout but ties with Ouyang Ke in the subsequent round, which involves appreciation of a piece of music played by Huang Yaoshi. The last assessment is a test of memory, in which Huang Yaoshi produces an incomplete copy of the Nine Yin Manual, without identifying the book, and asks the two contestants to memorise the text and recite to him later. Guo Jing read the manual before so he recites fluently and defeats Ouyang Ke.
Because the activation of telomerase is a relatively early event in the progression of cervical carcinogenesis, the expression of the human telomerase RNA gene, TERC, has the potential to serve as a biomarker for both the diagnosis and prognosis of cervical neoplasias. In total, 83 research centers participated in the study, and 7786 patients were...
School of Electronic, Information and Electrical Engineering The School of Electronic Information and Electrical Engineering (SEIEE) at Shanghai Jiao Tong University (SJTU) was established in 2001, with its glorious history traced back to 1908 when the discipline of Electric Machines was founded. With a century-long history of reputation in research and education, SEIEE is crowned as “the Cradle of Chinese Electrical Engineers”. The school now has 12 departments and principal units including the Department of Electrical Engineering, the Department of Automation, the Department of Computer Science and Engineering, the Department of Electronic Engineering, the Department of Instrument Science and Engineering, the Department of Micro-Nano Electronics, the School of Cyber Security, the School of Software, the Academy of Information Technology and Electrical Engineering, the Center for Advanced Electronic Materials and Devices, the Center for Teaching and Learning Development, and the Cooperative Medianet Innovation Center.
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