Golgi phosphoprotein 3 (GOLPH3), a newly recognized oncogene, is associated with tumor growth, metastasis, and poor prognosis in several types of cancer. However, its biological role and underlying mechanism in epithelial ovarian cancer (EOC) remain poorly understood. Here, we found that GOLPH3 was overexpressed in EOC tissues and cell lines. This...
Its population was 3,700,000 at the 2016 census whom 1,301,732 live in the built-up area made of 4 urban districts (Jiefang, Shanyang, Zhongzhan and Macun) and Bo'ai County being urbanized. Jiaozuo enjoys a humid subtropical climate with continental climate influences. Winters are cool and relatively dry while summers are hot and often rainy. Average temperature ranges from 0.3 °C in January to 27.5 °C in July. Extremes exist from -22.4 °C to 43.6 °C. Precipitation averages 659 mm.
Previously, we demonstrated that follicle stimulating hormone (FSH) enhanced VEGF expression and facilitated ovarian cancer angiogenesis via the PI3K/AKT signaling pathway. In this study, we further investigated the involvement of microRNA-27a: ZBTB10‑specificity protein pathway in the mechanism of FSH-induced VEGF, Cox2 and survivin expression. Tr...

Estrogen and progestin are involved in ovarian carcinogenesis. Change in nm23-H1 expression and the PIK3/AKT pathway are involved in carcinogenesis, development, invasion and metastasis of ovarian cancers. Therefore, it is critical to understand the signaling pathways that regulate hormone-induced cell migration and invasion in ovarian cancer. We i...
School of Pharmacy SJTU School of Pharmacy was founded in 2000, and now it has 85 academic, administrative and technical staff members. The School has 17 research and teaching laboratories covering the complete spectrum of curriculum and disciplines of pharmacy education and research including medicinal chemistry, pharmacology, pharmaceutics, pharmaceutical microbiology & biochemistry, pharmacognosy, and traditional Chinese medicine. SJTU School of Pharmacy is a research-orientated institution. Its graduate student body, enrolled in Ph.D., M.Sc. and M.Eng. programs, is as twice larger as its undergraduate classes. Both of the undergraduate and graduate courses are given by individual research laboratories each consisting of a professor and two to four junior academic staffs. SJTU School of Pharmacy has not only developed scientific programs but also nurtured an educational and research environment that is liberal and innovation-orientated. The school has now become a leading institute and an ideal place for pharmacy education and pharmaceutical research in the nation.
To investigate the effects of follicle stimulating hormone (FSH) on the proliferation, apoptosis, migration and invasion of ovarian cancer cells. Ovarian cancer cells of the lines SKOV-3 and ES-2 were cultured, and treated by FSH of the concentrations of 10, 20, 40, 80, and 160 mU/ml for 48 h or 24 h respectively. The cells without FSH treatment we...

Estrogen and progestin are involved in ovarian carcinogenesis. Change in nm23-H1 expression and the PIK3/AKT pathway are involved in carcinogenesis, development, invasion and metastasis of ovarian cancers. Therefore, it is critical to understand the signaling pathways that regulate hormone-induced cell migration and invasion in ovarian cancer. We i...
A cultural events package for the international student community at JI, including excursions into the environs of Shanghai, martial arts, Chinese cuisine and similar classes as well as cultural and social events is strongly recommended to be taken by all students at JI. The cost for the whole package is 2,500 RMB and must be paid in advance of coming to JI.
Metformin plays an important role in the inhibition of cancer cell growth and prolongs remission durations. It reverses progestin-resistance in endometrial cancer cells by downregulating glyoxalase I (GloI) expression. This study aimed to investigate the effect of metformin on endometrial cancer cell chemotherapeutic sensitivity and explore the und...
Progestin resistance is the main obstacle to successful conservative therapy in young endometrial cancer patients. To investigate the molecular events that lead to progestin resistance and to find a possible way to reverse progestin resistance in endometrial cancer, we established a progestin-resistant Ishikawa cell line by long-term progestin trea...
To investigate the effects of sulindac metabolites on proliferation and apoptosis in the human umbilical vein endothelial cell line ECV304 in vitro. The proliferation profile of ECV304 was determined by methyl thiazolyl tetrazolium (MTT) method. Cell cycle distribution, apoptosis and the ultrastructure of ECV304 were detected by flow cytometry (FCM...

To evaluate the therapeutic efficacies of preserving fertility treatment in patients with early cervical cancer. Sixteen patients with early cervical cancer treated by laparoscopic vaginal radical trachelectomy and pre- or postoperative chemotherapy were analyzed retrospectively, focusing on the treatment indication and management of high risk pati...

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) can induce apoptosis in various cancer cell lines with little toxicity toward normal cells. It offers a promising therapeutic method against ovarian cancer. Endothelial progenitor cells (EPCs) could home to tumor lesion, and take part in angiogenesis. This study was to observe antitumo...
To investigate the inhibitory effects of Snail--a zinc finger transcription factor, anti-sense plasmid on the invasion of ovary carcinoma cell lines in vitro. Four human ovarian carcinoma cell lines ES-2, OVCAR3, HO8910, HO8910PM were analyzed for the expression of Snail and E-cadherin mRNA by RT-PCR. Then anti-Snail plasmid transfection was introd...
Chemotherapy-resistance is the major obstacle for endometrial carcinoma patient administration. Accumulated evidences indicate that metformin sensitizes cancers from several different sites to chemotherapy drugs and reverses progestin resistance in endometrial cancer. Our group has demonstrated that metformin reverses progestin resistance and enhan...
To determine the role of oestrogen receptor α (ERα) in the regulation of survivin expression by 17β-estradiol (E(2)) in ovarian cancer cells and to evaluate the mechanism of E(2) action on ovarian cancer cell migration. We performed RT-PCR and Western blot analysis to assess the expression of ERα in the ovarian cancer cell lines NIH:OVCAR-3 and SKO...
A cultural events package for the international student community at JI, including excursions into the environs of Shanghai, martial arts, Chinese cuisine and similar classes as well as cultural and social events is strongly recommended to be taken by all students at JI. The cost for the whole package is 2,500 RMB and must be paid in advance of coming to JI.
... However, no clear morphologic changes were found between control cells and Snail-knockdown cells. 16 Although the Ecadherin expression could not be detected in these cells at protein lever (Fig. 1a), but there is significant upregulation of E-cadherin mRNA after knockdown expression of Snail (Fig. 1b), indicating that Snail is required to suppress the expression of E-cadherin in ovarian cancer. In addition, expression of fibronectin, one of the mesenchymal markers, was greatly downregulated in the stable antisense-Snail-transfected cells when compared with the parental cells (Fig. 1b). ...
Progestin resistance is the main obstacle to successful conservative therapy in young endometrial cancer patients. To investigate the molecular events that lead to progestin resistance and to find a possible way to reverse progestin resistance in endometrial cancer, we established a progestin-resistant Ishikawa cell line by long-term progestin trea...
School of Aeronautics and Astronautics The School of Aeronautics and Astronautics (SAA) is the main body of SJTU to cultivate talents for aerospace. The school consist of 3 departments and 2 research centers, namely, Department of Aircraft Design, Department of Aerospace Information and Control, Department of Propulsion, Near Space Research Center and J.C. Wu Center of Aerodynamics. Currently, SAA has more than 60 faculty members, 15 professors/researchers, 28 associate professors/associate researchers, which includes 2 Academician of the Chinese Academy of Engineering, 3 National “1000 Plan” Scholars, 2 Cheung Kong Professor. The school has 72 Doctoral Candidates, 205 Master Candidates, 112 Undergraduate students and 38 international students. SAA has maintained close and wide-ranging research cooperation and academic exchanges with many famous overseas universities and research institutions. The school also engages in visionary research projects to meet future demands and train highly qualified aerospace professionals for the future development of the world’s aerospace industry.
Most buildings on campus were influenced by American architecture, while the main gate, which was built in 1935, is of traditional Chinese style reflecting the University's earlier status as the "Imperial Polytechnic College". The approaches to the main gate were via a series of marble bridges, similar to, although smaller than, those built in front of Tiananmen. However, recent road expansions have demolished the river as well as most of bridges. A copy of this famous gate scene have been built on the east of Minhang campus.

Huang Yaoshi is very protective of his daughter and loves her with his life as she reminds him of his deceased wife. He imparts all his skills to her since she was a child and hoped to groom her to become his heir. When his daughter reaches adolescence, he decides to find a suitable husband for her. Ouyang Feng visits Peach Blossom Island with his nephew, Ouyang Ke, to propose a marriage between Ouyang Ke and Huang Rong. Huang Yaoshi favours Ouyang Ke and wants him to be his son-in-law. At the same time, Guo Jing also visits the island with his master, Hong Qigong. Hong Qigong nominates his apprentice to be Huang Yaoshi's son-in-law. Huang Yaoshi had met Guo Jing earlier at Guiyun Manor and wants to kill Guo to avenge Chen Xuanfeng.
Ovarian cancer is the leading cause of death among gynecologic cancers and is the fifth leading cause of all cancer-related deaths among women. The development of novel molecular targets is therefore important to many patients. Recently, the SRY-related transcription factor SOX2 has been widely reported to be involved in multiple pathophysiological...

Objective: This research was carried out to investigate the effectiveness, rationality, and safety of laparotomy management compared with uterine artery embolization (UAE) combined with methotrexate (MTX) for the treatment of deep implantation cesarean scar pregnancy (CSP II). Materials and methods: Data from 29 patients seen between June 2008 and...
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