Chemotherapy-resistance is the major obstacle for endometrial carcinoma patient administration. Accumulated evidences indicate that metformin sensitizes cancers from several different sites to chemotherapy drugs and reverses progestin resistance in endometrial cancer. Our group has demonstrated that metformin reverses progestin resistance and enhan...
Progestin is an effective endocrine treatment for patients with atypical hyperplasia or with endometrial carcinoma that is estrogen receptor (ER) positive and progesterone receptor (PR) positive. However, long-term progestin treatment may lead to resistance. We have studied the progestin resistance phenotype that frequently develops in endometrial...
Up to 30% of failure rate in endometrial hyperplasia patients treated by progestin urges more detailed understanding of the mechanisms involved in progestin resistance. Survivin is a key regulator in the antiapoptotic network, and overexpression of survivin has been reported in endometrial hyperplasia and cancer. This study investigated the role of...
Large amount of clinical evidence has demonstrated that insulin resistance is closely related to oncogenesis of endometrial cancer (EC). Despite recent studies showed the up-regulatory role of insulin in G protein-coupled estrogen receptor (GPER/GPR30) expression, GPER expression was not decreased compared to control when insulin receptor was block...
Background: Insulin resistance (IR) has been well studied in the initiation and development of endometrial endometrioid carcinoma (EEC). As yet, it has been largely neglected for estrogen sensitivity in local endometrium in hyperinsulinemia-induced systemic microenvironment. The aim of this study was to investigate the role of insulin in regulating...
Recent studies have suggested that follicle-stimulating hormone (FSH) plays an important role in ovarian epithelial carcinogenesis. We demonstrated that FSH stimulates the proliferation and invasion of ovarian cancer cells, inhibits apoptosis, and facilitates neovascularisation. Our previous work has shown that transient receptor potential channel...
IQGAP1 is a scaffolding protein and overexpressed in many human tumors, including ovarian cancer. However, the contribution of IQGAP1 to invasive properties of ovarian cancer cells remains unknown. Here, we investigated the effect of IQGAP1-specific short hairpin RNA (shRNA) expressing plasmids on metastatic potential of ovarian cancer HO-8910PM ce...
Zhiyuan College The Zhiyuan College, established in January 2010, offers “Zhiyuan Honors Program” to the top 5% SJTU undergraduates. Today, Zhiyuan has seven undergraduate programs: Mathematics, Physics, Life Science, Computer Science, Chemistry, Engineering and Biomedical Science. Aiming at cultivating top-notch talents into international academic masters, Zhiyuan College has recruited a group of eminent scholars from around the world to build first-class faculty team. Each year, Zhiyuan admits 350 students and there are 433 alumni worldwide currently, 90% of whom are pursuing further studies at top domestic and international universities and institutions. In addition to having a strong academic record, students who show a strong interest and the potential to pursue a research career are selected. In 2014, the talent training model of Zhiyuan College won the first-class award of “National Teaching Achievement Award”; and in 2016, “Zhiyuan Model” won “Cultivating Curiosity Award” and “Natural Sciences Award” of “Reimagine Education 2016”, which is jointly hosted by Wharton School of the University of Pennsylvania and QS—international institution for world university rankings on education.
In 1945, after the defeat of the Japanese in the Second World War, he returned his hometown and joined a militia. He once took part in the battle of liberating Boshan District. Jiao Yulu joined the Communist Party of China in January 1946, and he soon was transferred to Bohai, Shandong and appointed a group leader of the Land Reform movement. By late Chinese Civil War, he worked in Weishi County, Henan province until 1951. In June 1953, he was transferred to Luoyang Mine Machine Manufacturing Plant and worked there until 1962.
Huiyuan began studying the Zhuangzi and Laozi at a young age, as well as the teachings of Confucius. However, at the age of 21 he was converted in Hebei Province by the Buddhist Dao An, who was a Chinese disciple of a Kuchan missionary. Hearing the sermons of Dao An convinced Huiyuan to "leave the family" and embark on a life of Buddhist teachings.[1] Later, he became a patriarch of Donglin Temple (East Forest Temple) at Mount Lushan. His teachings were various, including the vinaya (戒律), meditation (禪法), abhidharma and Prajna or wisdom. Although Huiyuan did not take the initiative in establishing the relations with the secular world, he had contacts with court and gentry families. Huiyuan was on two occasions invited by the dictator Huan Xuan to take part in the discussions about the status of the clergy and Huiyuan defended the independence of the clergy. Members of the cultured classes came to live on Mount Lu as Huiyuan's lay disciples to take part in the religious life. Besides his teaching and interaction with lay followers of the Buddhist faith, he also upheld a learned correspondence with the monk Kumarajiva.[2]
USC-SJTU Institute of Cultural and Creative Industry USC-SJTU Institute of Cultural and Creative Industry (ICCI) is jointly established by Shanghai Jiao Tong University (SJTU) and University of Southern California (USC). With supports from all aspects of the society, ICCI aims to develop itself into a pilot of international collaboration in the field of cultural and creative industry.When culture leads, creativity triumphs. Located in the economic and financial center of China and taking the revitalization of the country and the nation as its own mission, Shanghai Jiao Tong University has cultivated numerous elites in politics, science, industries and arts, and has made great contributions to the country’s economics, science and technology, arts, and health care since founded in 1896. There are a number of famous alumni such as Li Shutong (a master of culture and arts), Lu Yan (a Chinese Hollywood Actress), Hong Shen (a dramatist), and Zhu Qizhan (a famous painter). This manifests the great contribution SJTU has made to the culture and creative industry. University of Southern California is located in Los Angeles, the cultural capital of the world. It has enjoyed a long-lasting high reputation for cultivating a large number of elites in the cultural and creative industry.
Ovarian clear cell adenocarcinoma (OCCA) is an aggressive ovarian malignancy with a poor prognosis. The role of estrogen receptor β (ERβ) in the development of OCCA remains to be clarified. To investigate the action of ERβ in the proliferation and invasion of OCCA cells, the ES-2 cell line was stably transfected with full-length human ERβ cDNA, and...

School of Materials Science and Engineering School of Materials Science and Engineering, Shanghai Jiao Tong University originated from the metal heat treatment major in 1952, and was established by merging Materials Science Department and Materials Engineering Department in 1997. The School has been ranked among ESI world top 1‰ disciplines for consecutive years, the discipline ranked 31st in 2016 QS world ranking and the 2nd among domestic disciplines. There are about 300 faculty and staff members, including 1 academicians of the Chinese Academy of Sciences,4 academicians of the Chinese Academy of Engineering, 4 YangtzeRiver Scholars and 4 winners of the National Fund for Distinguished Young Scholars of China. The School has about 1,500 students, including about 560 undergraduates, 470 master degree candidates, 360 doctoral candidates and 150 engineering masters. The School has formed 13 distinctive teaching and research teams by compacting discipline orientation and integrating academic teams.
School of Environmental Science and Engineering Environmental Science and Engineering (ESE) at Shanghai Jiao Tong University (SJTU) originated from the municipal engineering program established in 1926. The School of Environmental Science and Engineering (SESE) was formally established in 1999 and environmental engineering doctorate program and environmental engineering master program of engineering were established in 2001 and 2002, respectively. In 2003,the first level discipline doctoral program of environmental science and engineering was approved.

A few highly aggressive and malignant tumor cells could acquire identities by turning on genes expressed by endothelial cells and recruit blood vessels to sustain tumor growth. Hypoxia was reported recently to play an essential role in these events. These 'plastic' tumor-cell phenotypes and the exact mechanism driving transendothelial differentiati...

Our previous study revealed that estrogen regulates nm23-H1 expression thus promoting cell migration-invasion via activating PIK3/Akt pathway. In this study, we explored the effect of hormone on hypoxia-inducible factor-1 (HIF-1alpha), a key factor in cancer invasion and metastasis, via activation of Akt signaling transduction pathway. We treated t...
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