To study the expression of intermediate-conductance-Ca(2+)-activated K(+) (IKCa1) channels in endometrial cancer and its role in regulating proliferation of endometrial cancer cells. Western blot and RT-PCR were used to examine the expression of IKCa1 channels in 13 normal endometrial specimens and 25 endometrial cancer specimens; and RNA interfere...
To evaluate the therapeutic efficacies of preserving fertility treatment in patients with early cervical cancer. Sixteen patients with early cervical cancer treated by laparoscopic vaginal radical trachelectomy and pre- or postoperative chemotherapy were analyzed retrospectively, focusing on the treatment indication and management of high risk pati...
To investigate the inhibitory effects of Snail--a zinc finger transcription factor, anti-sense plasmid on the invasion of ovary carcinoma cell lines in vitro. Four human ovarian carcinoma cell lines ES-2, OVCAR3, HO8910, HO8910PM were analyzed for the expression of Snail and E-cadherin mRNA by RT-PCR. Then anti-Snail plasmid transfection was introd...

Henan Polytechnic University (HPU)[1], with a history of nearly 100 years, is the first mining university in Chinese history. Its former is Jiaozuo Coal Mining School which was established by the British Syndicate Co. Ltd., in 1909. It has changed its names several times in the course of development, namely, FuZhong Coal Mining University, Jiaozuo Private Institute of Technology, North-west Institute of Technology, Jiaozuo National Institute of Technology, Jiaozuo Mining Institute and Jiaozuo Institute of Technology. The University resumed its name of Henan Polytechnic University in 2004.
To compare the therapeutic and toxic profile of topotecan given intraperitoneally with intravenously in human ovarian cancer xenografted into athymic nude mice. Eighty female Balb-c/nu-nu mice were randomized assigned into eight groups (n=10). Xenografts resulted from intramesentery injection of cultured human ovarian cancer cells SKOV3 in athymic...
... Interestingly, estradiol may play a dual role in modulating NRF2 activity. On the one hand, its metabolites activate NRF2 via the generation of reactive oxygen species (ROS) (independent of the ER) [29]. While recent studies demonstrated that estradiol leads to an activation of NRF2 in a wide range of cell types [30,31], the estradiol effect was only noted on protein and not on mRNA levels, suggesting that the main effect of estradiol is based on NRF2 protein stabilization [32]. ...
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